4J36
Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 401 |
| Chain | Residue |
| A | ILE8 |
| A | ALA53 |
| A | ARG109 |
| A | HIS131 |
| A | LYS132 |
| A | LEU133 |
| A | CYS167 |
| A | ASP168 |
| A | GLY169 |
| A | ALA173 |
| A | GLY313 |
| A | GLY9 |
| A | ASP314 |
| A | GLN325 |
| A | GLY326 |
| A | MET327 |
| A | ASN328 |
| A | HOH501 |
| A | HOH508 |
| A | HOH531 |
| A | HOH548 |
| A | HOH626 |
| A | GLY11 |
| A | HOH672 |
| A | HOH710 |
| A | HOH716 |
| A | HOH717 |
| A | LEU12 |
| A | VAL13 |
| A | ASP32 |
| A | PHE33 |
| A | ARG34 |
| A | LEU52 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD B 401 |
| Chain | Residue |
| B | GLY9 |
| B | GLY11 |
| B | LEU12 |
| B | VAL13 |
| B | ASP32 |
| B | PHE33 |
| B | ARG34 |
| B | ASN46 |
| B | LEU52 |
| B | ALA53 |
| B | ARG109 |
| B | HIS131 |
| B | LYS132 |
| B | LEU133 |
| B | CYS167 |
| B | ASP168 |
| B | GLY169 |
| B | ALA173 |
| B | TYR195 |
| B | GLY313 |
| B | ASP314 |
| B | GLY324 |
| B | GLN325 |
| B | GLY326 |
| B | MET327 |
| B | ASN328 |
| B | 1HR402 |
| B | HOH501 |
| B | HOH506 |
| B | HOH578 |
| B | HOH600 |
| B | HOH604 |
| B | HOH629 |
| B | HOH640 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1HR B 402 |
| Chain | Residue |
| B | ALA53 |
| B | ARG83 |
| B | TYR97 |
| B | ILE104 |
| B | LEU221 |
| B | ILE232 |
| B | PHE246 |
| B | PRO321 |
| B | PHE322 |
| B | TYR323 |
| B | FAD401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4J2W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J31","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J34","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J36","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q84HF5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4J33","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
