5LDM
 
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5N4P
 | | Human myelin P2, mutant I52T | | Descriptor: | D-MALATE, Myelin P2 protein, PALMITIC ACID, ... | | Authors: | Ruskamo, S, Kursula, P. | | Deposit date: | 2017-02-11 | | Release date: | 2017-08-09 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.533 Å) | | Cite: | Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2.
Sci Rep, 7, 2017
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7ALM
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7AIA
 | | Complex of human GDAP1 with hexadecanedioic acid | | Descriptor: | ETHANOL, GLYCEROL, Ganglioside-induced differentiation-associated protein 1, ... | | Authors: | Nguyen, G.T.T, Sutinen, A, Kursula, P. | | Deposit date: | 2020-09-26 | | Release date: | 2021-02-24 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations.
Front Mol Biosci, 7, 2020
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5LXX
 | | High-resolution structure of human collapsin response mediator protein 2 | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydropyrimidinase-related protein 2, SULFATE ION | | Authors: | Myllykoski, M, Hensley, K, Kursula, P. | | Deposit date: | 2016-09-23 | | Release date: | 2017-01-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.
Amino Acids, 49, 2017
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5LDJ
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5LDK
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5LDP
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6ZMM
 | | Crystal structure of human NDRG1 | | Descriptor: | CHLORIDE ION, Protein NDRG1 | | Authors: | Mustonen, V, Kursula, P, Ruskamo, S. | | Deposit date: | 2020-07-03 | | Release date: | 2020-12-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Crystal and solution structure of NDRG1, a membrane-binding protein linked to myelination and tumour suppression.
Febs J., 288, 2021
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5LDQ
 | | Crystal structure of E.coli LigT complexed with NADP+ | | Descriptor: | CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PENTAETHYLENE GLYCOL, ... | | Authors: | Myllykoski, M, Kursula, P. | | Deposit date: | 2016-06-27 | | Release date: | 2017-01-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase.
PLoS ONE, 12, 2017
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7B2G
 | | Crystal structure of R120Q GDAP1 mutant | | Descriptor: | GLYCEROL, Ganglioside-induced differentiation-associated protein 1 | | Authors: | Nguyen, G.T.T, Sutinen, A, Kursula, P. | | Deposit date: | 2020-11-26 | | Release date: | 2021-12-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability.
Plos One, 18, 2023
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6GZJ
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6GZL
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6HYF
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2FIM
 | | Structure of the C-terminal domain of Human Tubby-like protein 1 | | Descriptor: | 3-(N,N-DIMETHYLOCTYLAMMONIO)PROPANESULFONATE, SULFATE ION, Tubby related protein 1 | | Authors: | Hallberg, B.M, Ogg, D, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Graslund, S, Hammarstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Kursula, P, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Persson, C. | | Deposit date: | 2005-12-29 | | Release date: | 2006-02-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the C-terminal domain of Human Tubby-like protein 1
To be published
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2BZN
 | | Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP | | Descriptor: | GMP REDUCTASE 2, INOSINIC ACID | | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Graslund, S, Hammarstrom, M, Hallberg, B.M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A, Weigelt, J. | | Deposit date: | 2005-08-19 | | Release date: | 2005-09-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.
Nat.Chem.Biol., 7, 2011
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2CAR
 | | Crystal Structure Of Human Inosine Triphosphatase | | Descriptor: | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | | Authors: | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Hogbom, M, Holmberg Schiavone, L, Kotenyova, T, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P. | | Deposit date: | 2005-12-22 | | Release date: | 2006-01-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.09 Å) | | Cite: | Crystal Structure of Human Inosine Triphosphatase. Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
J.Biol.Chem., 282, 2007
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5OVC
 | | PDZ domain from rat Shank3 bound to the C terminus of GKAP | | Descriptor: | CHLORIDE ION, GKAP C terminus, synthetic peptide, ... | | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | | Deposit date: | 2017-08-28 | | Release date: | 2018-03-07 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.
J. Neurochem., 145, 2018
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5O99
 | | Unconventional SH3 domain from the postsynaptic density scaffold protein Shank3 | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SH3 and multiple ankyrin repeat domains protein 3 | | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | | Deposit date: | 2017-06-16 | | Release date: | 2017-07-05 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (0.871 Å) | | Cite: | Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.
Biochem. Biophys. Res. Commun., 490, 2017
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5OVV
 | | PDZ domain from rat Shank3 bound to the C terminus of ProSAPiP1 | | Descriptor: | Leucine zipper putative tumor suppressor 3, SH3 and multiple ankyrin repeat domains protein 3, THIOCYANATE ION | | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | | Deposit date: | 2017-08-29 | | Release date: | 2018-03-07 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.
J. Neurochem., 145, 2018
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5OVA
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5OVP
 | | PDZ domain from rat Shank3 bound to the C terminus of CIRL | | Descriptor: | Adhesion G protein-coupled receptor L1, SH3 and multiple ankyrin repeat domains protein 3 | | Authors: | Ponna, S.K, Myllykoski, M, Boeckers, T.M, Kursula, P. | | Deposit date: | 2017-08-29 | | Release date: | 2018-03-07 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.
J. Neurochem., 145, 2018
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2J9Q
 | | A novel conformation for the TPR domain of pex5p | | Descriptor: | PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, STRONTIUM ION | | Authors: | Stanley, W.A, Wilmanns, M, Kursula, P. | | Deposit date: | 2006-11-15 | | Release date: | 2007-04-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | A Previously Unobserved Conformation for the Human Pex5P Receptor Suggests Roles for Intrinsic Flexibility and Rigid Domain Motions in Ligand Binding
Bmc Struct.Biol., 7, 2007
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2Y3X
 | | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with sulfate | | Descriptor: | 2', 3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE, GLYCEROL, ... | | Authors: | Myllykoski, M, Kursula, P. | | Deposit date: | 2011-01-04 | | Release date: | 2012-01-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation.
Plos One, 7, 2012
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2Y1P
 | | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate | | Descriptor: | 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRIC ACID, ... | | Authors: | Myllykoski, M, Kursula, P. | | Deposit date: | 2010-12-09 | | Release date: | 2011-12-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation.
Plos One, 7, 2012
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