1MLV
 
 | | Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ribulose-1,5 biphosphate carboxylase/oxygenase large subunit N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Trievel, R.C, Beach, B.M, Dirk, L.M.A, Houtz, R.L, Hurley, J.H. | | Deposit date: | 2002-08-30 | | Release date: | 2002-10-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure and catalytic mechanism of a SET domain protein methyltransferase.
Cell(Cambridge,Mass.), 111, 2002
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1OZV
 | | Crystal structure of the SET domain of LSMT bound to Lysine and AdoHcy | | Descriptor: | LYSINE, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast, ... | | Authors: | Trievel, R.C, Flynn, E.M, Houtz, R.L, Hurley, J.H. | | Deposit date: | 2003-04-09 | | Release date: | 2003-07-01 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT
Nat.Struct.Biol., 10, 2003
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1MN3
 | | Cue domain of yeast Vps9p | | Descriptor: | Vacuolar protein sorting-associated protein VPS9 | | Authors: | Prag, G, Misra, S, Jones, E, Ghirlando, R, Davies, B.A, Horazdovsky, B.F, Hurley, J.H. | | Deposit date: | 2002-09-04 | | Release date: | 2003-06-10 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p
Cell(Cambridge,Mass.), 113, 2003
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1NWM
 | | GAT domain of human GGA1 | | Descriptor: | ADP-ribosylation factor binding protein GGA1 | | Authors: | Suer, S, Misra, S, Saidi, L.F, Hurley, J.H. | | Deposit date: | 2003-02-06 | | Release date: | 2003-03-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor.
Proc.Natl.Acad.Sci.USA, 100, 2003
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1P4U
 | | CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE | | Descriptor: | ADP-ribosylation factor binding protein GGA3, Rabaptin-5 | | Authors: | Miller, G.J, Mattera, R, Bonifacino, J.S, Hurley, J.H. | | Deposit date: | 2003-04-24 | | Release date: | 2003-07-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | RECOGNITION OF ACCESSORY PROTEIN MOTIFS BY THE GAMMA-ADAPTIN EAR DOMAIN OF GGA3
Nat.Struct.Biol., 10, 2003
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1PTQ
 | | PROTEIN KINASE C DELTA CYS2 DOMAIN | | Descriptor: | PROTEIN KINASE C DELTA TYPE, ZINC ION | | Authors: | Zhang, G, Hurley, J.H. | | Deposit date: | 1995-05-11 | | Release date: | 1995-07-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.
Cell(Cambridge,Mass.), 81, 1995
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1PTR
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1ELK
 | | VHS domain of TOM1 protein from H. sapiens | | Descriptor: | TARGET OF MYB1 | | Authors: | Misra, S, Beach, B, Hurley, J.H. | | Deposit date: | 2000-03-13 | | Release date: | 2000-03-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes
Biochemistry, 39, 2000
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1F5M
 | | STRUCTURE OF THE GAF DOMAIN | | Descriptor: | BROMIDE ION, GAF | | Authors: | Ho, Y.S, Burden, L.M, Hurley, J.H. | | Deposit date: | 2000-06-15 | | Release date: | 2000-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor.
EMBO J., 19, 2000
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1EM2
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1I9Y
 | | CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN | | Descriptor: | PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE | | Authors: | Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H. | | Deposit date: | 2001-03-21 | | Release date: | 2001-05-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
Cell(Cambridge,Mass.), 105, 2001
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1I9Z
 | | CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION | | Descriptor: | CALCIUM ION, D-MYO-INOSITOL-1,4-BISPHOSPHATE, PHOSPHATIDYLINOSITOL PHOSPHATE PHOSPHATASE | | Authors: | Tsujishita, Y, Guo, S, Stolz, L, York, J.D, Hurley, J.H. | | Deposit date: | 2001-03-21 | | Release date: | 2001-05-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
Cell(Cambridge,Mass.), 105, 2001
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1JUQ
 | | GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose 6-phosphate receptor | | Descriptor: | ADP-RIBOSYLATION FACTOR BINDING PROTEIN GGA3, Cation-dependent mannose-6-phosphate receptor | | Authors: | Misra, S, Puertollano, R, Bonifacino, J.S, Hurley, J.H. | | Deposit date: | 2001-08-26 | | Release date: | 2002-02-27 | | Last modified: | 2016-10-12 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.
Nature, 415, 2002
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1JPL
 | | GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor | | Descriptor: | ADP-RIBOSYLATION FACTOR BINDING PROTEIN GGA3, Cation-Independent Mannose 6-phosphate receptor | | Authors: | Misra, S, Puertollano, R, Bonifacino, J.S, Hurley, J.H. | | Deposit date: | 2001-08-02 | | Release date: | 2002-02-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.
Nature, 415, 2002
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1BL5
 | | ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION | | Descriptor: | 2-OXOGLUTARIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ... | | Authors: | Stoddard, B.L, Cohen, B, Brubaker, M, Mesecar, A, Koshland Junior, D.E. | | Deposit date: | 1998-07-23 | | Release date: | 1999-05-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs.
Nat.Struct.Biol., 5, 1998
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5L1Z
 | | TAR complex with HIV-1 Tat-AFF4-P-TEFb | | Descriptor: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | | Authors: | Schulze-Gahmen, U, Hurley, J. | | Deposit date: | 2016-07-29 | | Release date: | 2016-10-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (5.9 Å) | | Cite: | Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Elife, 5, 2016
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7R4H
 | | phospho-STING binding to adaptor protein complex-1 | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Xu, P, Ablasser, A. | | Deposit date: | 2022-02-08 | | Release date: | 2022-09-14 | | Last modified: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (2.34 Å) | | Cite: | Clathrin-associated AP-1 controls termination of STING signalling.
Nature, 610, 2022
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5PTP
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4N7H
 | | Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of ARRDC3 | | Descriptor: | Arrestin domain-containing protein 3, E3 ubiquitin-protein ligase NEDD4, GUANIDINE | | Authors: | Qi, S, O'Hayre, M, Gutkind, J.S, Hurley, J. | | Deposit date: | 2013-10-15 | | Release date: | 2014-01-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.698 Å) | | Cite: | Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3).
J.Biol.Chem., 289, 2014
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4N7F
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6GMA
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4R7X
 | | Crystal structure of N-lobe of human ARRDC3(1-180) | | Descriptor: | Arrestin domain-containing protein 3, PHOSPHATE ION | | Authors: | Qi, S, Hurley, J. | | Deposit date: | 2014-08-28 | | Release date: | 2014-10-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.
Protein Sci., 23, 2014
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4R7V
 | | Crystal structure of N-lobe of human ARRDC3(1-165) | | Descriptor: | Arrestin domain-containing protein 3 | | Authors: | Qi, S, Hurley, J. | | Deposit date: | 2014-08-28 | | Release date: | 2014-10-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.
Protein Sci., 23, 2014
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7UXH
 | | cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Cui, Z, Hurley, J. | | Deposit date: | 2022-05-05 | | Release date: | 2022-11-30 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
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7UX2
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