8F7G
| The condensation domain of surfactin A synthetase C in space group P212121 | 分子名称: | GLYCEROL, Surfactin synthetase | 著者 | Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, T.M. | 登録日 | 2022-11-18 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 2024
|
|
8F7H
| The condensation domain of surfactin A synthetase C variant 18b in space group P212121 | 分子名称: | GLYCEROL, Surfactin synthetase | 著者 | Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. | 登録日 | 2022-11-18 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 2024
|
|
8F7I
| The condensation domain of surfactin A synthetase C variant 18b in space group P43212 | 分子名称: | GLYCEROL, Surfactin synthetase | 著者 | Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. | 登録日 | 2022-11-18 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 2024
|
|
6FDB
| |
5N82
| Crystal structure of an engineered TycA variant in complex with an beta-Phe-AMP analog | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | 著者 | Niquille, D.L, Hansen, D.L, Mori, T, Fercher, D, Kries, H, Hilvert, D. | 登録日 | 2017-02-22 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | 主引用文献 | Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem, 10, 2018
|
|
5N81
| Crystal structure of an engineered TycA variant in complex with an O-propargyl-beta-Tyr-AMP analog | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, Tyrocidine synthase 1, ... | 著者 | Niquille, D.L, Hansen, D.A, Mori, T, Fercher, D, Kries, H, Hilvert, D. | 登録日 | 2017-02-22 | 公開日 | 2017-12-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Nonribosomal biosynthesis of backbone-modified peptides. Nat Chem, 10, 2018
|
|
6SRZ
| Kemp Eliminase HG3.17 mutant Q50H, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, GLYCEROL, Kemp Eliminase HG3.17 Q50H, ... | 著者 | Bloch, J.S, Pinkas, D.M, Hilvert, D. | 登録日 | 2019-09-06 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
|
|
6SS1
| Kemp Eliminase HG3.17 mutant Q50A, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Kemp Eliminase HG3.17 Q50A, E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole, ... | 著者 | Bloch, J.S, Pinkas, D.M, Hilvert, D. | 登録日 | 2019-09-06 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
|
|
6SS3
| Kemp Eliminase HG3.17 mutant Q50K, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, GLYCEROL, Kemp Eliminase HG3.17 Q50K, ... | 著者 | Bloch, J.S, Pinkas, D.M, Hilvert, D. | 登録日 | 2019-09-06 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
|
|
6SRY
| Kemp Eliminase HG3.17 mutant Q50S, E47N, N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Kemp Eliminase HG3.17 Q50S, E47N,N300D, ... | 著者 | Bloch, J.S, Pinkas, D.M, Hilvert, D. | 登録日 | 2019-09-06 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiencyproficiency Acs Catalysis, 2020
|
|
6TFA
| |
6TU6
| |
3UD6
| Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | 著者 | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | 登録日 | 2011-10-27 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
|
|
3ZOP
| Arg90Cit chorismate mutase of Bacillus subtilis at 1.6 A resolution | 分子名称: | CHORISMATE MUTASE AROH | 著者 | Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. | 登録日 | 2013-02-22 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3ZP4
| Arg90Cit chorismate mutase of Bacillus subtilis in complex with a transition state analog | 分子名称: | 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID, CHORISMATE MUTASE AROH | 著者 | Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. | 登録日 | 2013-02-26 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3ZP7
| Arg90Cit chorismate mutase of Bacillus subtilis in complex with chorismate and prephenate | 分子名称: | (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid, CHORISMATE MUTASE AROH, PREPHENIC ACID | 著者 | Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. | 登録日 | 2013-02-26 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3ZO8
| Wild-type chorismate mutase of Bacillus subtilis at 1.6 A resolution | 分子名称: | CHORISMATE MUTASE AROH | 著者 | Burschowsky, D, vanEerde, A, Okvist, M, Kienhofer, A, Kast, P, Hilvert, D, Krengel, U. | 登録日 | 2013-02-20 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Electrostatic Transition State Stabilization Rather Than Reactant Destabilization Provides the Chemical Basis for Efficient Chorismate Mutase Catalysis. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4A2R
| Structure of the engineered retro-aldolase RA95.5-5 | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE | 著者 | Giger, L, Caner, S, Kast, P, Baker, D, Ban, N, Hilvert, D. | 登録日 | 2011-09-28 | 公開日 | 2012-11-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.302 Å) | 主引用文献 | Evolution of a designed retro-aldolase leads to complete active site remodeling. Nat.Chem.Biol., 9, 2013
|
|
7K4X
| Crystal structure of Kemp Eliminase HG3.7 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, ACETATE ION, Endo-1,4-beta-xylanase, ... | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
7K4Y
| Crystal structure of Kemp Eliminase HG3.17 at 343 K | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
7K4Z
| Crystal structure of Kemp Eliminase HG3.17 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, PENTAETHYLENE GLYCOL | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
7K4Q
| Crystal structure of Kemp Eliminase HG3 in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase, SULFATE ION | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
7K4V
| Crystal structure of Kemp Eliminase HG3.17 | 分子名称: | Endo-1,4-beta-xylanase, TETRAETHYLENE GLYCOL | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
7K4U
| Crystal structure of Kemp Eliminase HG3 K50Q in complex with the transition state analog 6-nitrobenzotriazole | 分子名称: | 6-NITROBENZOTRIAZOLE, Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
|
|
4A29
| Structure of the engineered retro-aldolase RA95.0 | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, D-MALATE, ENGINEERED RETRO-ALDOL ENZYME RA95.0 | 著者 | Giger, L, Caner, S, Kast, P, Baker, D, Ban, N, Hilvert, D. | 登録日 | 2011-09-23 | 公開日 | 2012-11-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Evolution of a designed retro-aldolase leads to complete active site remodeling. Nat.Chem.Biol., 9, 2013
|
|