8P20
| TarM(Se)_G117R-UDP-4RboP-glucose | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Guo, Y, Stehle, T. | Deposit date: | 2023-05-14 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.848 Å) | Cite: | Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition. Sci Adv, 9, 2023
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7CJF
| Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | Authors: | Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z. | Deposit date: | 2020-07-10 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.108 Å) | Cite: | A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun, 12, 2021
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5Y6J
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3U3I
| A RNA binding protein from Crimean-Congo hemorrhagic fever virus | Descriptor: | Nucleocapsid protein | Authors: | Guo, Y, Wang, W.M, Ji, W, Deng, M, Sun, Y.N, Lou, Z.Y, Rao, Z.H. | Deposit date: | 2011-10-06 | Release date: | 2012-03-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses Proc.Natl.Acad.Sci.USA, 109, 2012
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3U1U
| Crystal structure of RNA polymerase-associated protein RTF1 homolog Plus-3 domain | Descriptor: | GLYCEROL, RNA polymerase-associated protein RTF1 homolog, SULFATE ION, ... | Authors: | Guo, Y, Tempel, W, Bian, C, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2011-09-30 | Release date: | 2012-04-04 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of RNA polymerase-associated protein RTF1 homolog Plus-3 domain to be published
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7VIB
| Crystal structure of human ACE2 and GX/P2V RBD | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein, ZINC ION | Authors: | Guo, Y, Cao, W, Jia, N, Wang, W, Yuan, S, Wang, Y. | Deposit date: | 2021-09-26 | Release date: | 2022-10-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of human ACE2 and GX/P2V RBD To Be Published
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7C9N
| Crystal structure of SETDB1 tudor domain in complexed with Compound 1. | Descriptor: | 3,5-dimethyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1 | Authors: | Guo, Y, Xiong, L, Mao, X, Yang, S. | Deposit date: | 2020-06-06 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.472 Å) | Cite: | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7DBW
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7D2F
| Lp major histidine acid phosphatase mutant D281A/5'-AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Major acid phosphatase | Authors: | Guo, Y, Teng, Y. | Deposit date: | 2020-09-16 | Release date: | 2021-09-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila. Biochem.Biophys.Res.Commun., 540, 2021
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7DOQ
| Lp major histidine acid phosphatase mutant D281A/5'-AMP | Descriptor: | Acid phosphatase, PHOSPHATE ION | Authors: | Guo, Y, Teng, Y. | Deposit date: | 2020-12-16 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila. Biochem.Biophys.Res.Commun., 540, 2021
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5ZPW
| Generation of a long-acting fusion inhibitor against HIV-1 | Descriptor: | MET-THR-TRP-GLU-GLU-TRP-ASP-MK8-LYS-ILE-GLU-MK8-TYR-THR-MK8-LYS-ILE-GLU-MK8-LEU-ILE-LYS-LYS-SER, Transmembrane protein gp41 | Authors: | Guo, Y, Shi, X.L. | Deposit date: | 2018-04-16 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Generation of a long-acting fusion inhibitor against HIV-1. Medchemcomm, 9, 2018
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7CJU
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7CZA
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6IWF
| Crystal structure of HitA from Pseudomonas aeruginosa | Descriptor: | Ferric iron-binding protein HitA | Authors: | Guo, Y, Zhengrui, Z, Li, H. | Deposit date: | 2018-12-05 | Release date: | 2019-12-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.70662332 Å) | Cite: | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa. Acs Infect Dis., 5, 2019
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6J2S
| Structure of HitA bound to gallium from Pseudomonas aeruginosa | Descriptor: | Ferric iron-binding periplasmic protein, GALLIUM (III) ION, PHOSPHATE ION | Authors: | Guo, Y, Li, H.Y, Sun, H.Z, Xia, W. | Deposit date: | 2019-01-02 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.73005116 Å) | Cite: | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa. Acs Infect Dis., 5, 2019
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6LR1
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7XGQ
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7XGC
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8WNF
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in apo form | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-05 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WO2
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val-AMP | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WNJ
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile-AMP | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WNG
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Ile | Descriptor: | ACETATE ION, GLYCEROL, ISOLEUCINE, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-05 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WNI
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Val | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GLYCEROL, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8WO3
| Crystal structure of H. pylori isoleucyl-tRNA synthetase (HpIleRS) in complex with Mupirocin | Descriptor: | ACETATE ION, GLYCEROL, Isoleucine--tRNA ligase, ... | Authors: | Guo, Y, Li, S, Zhang, T. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for substrate and antibiotic recognition by Helicobacter pylori isoleucyl-tRNA synthetase. Febs Lett., 598, 2024
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8GPY
| Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv | Descriptor: | Spike protein S1, scFv | Authors: | Gao, Y.X, Song, Z.D, Wang, W.M, Guo, Y. | Deposit date: | 2022-08-27 | Release date: | 2023-06-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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