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SAP domain from Tho1: L31W (fluorophore) mutant
分子名称:	PROTEIN THO1
著者	Dodson, C.A, Ferguson, N, Rutherford, T.J, Johnson, C.M, Fersht, A.R.
登録日	2009-08-21
公開日	2010-02-16
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Engineering a Two-Helix Bundle Protein for Folding Studies. Protein Eng.Des.Sel., 23, 2010

2XWR

Crystal structure of the DNA-binding domain of human p53 with extended N terminus
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Natan, E, Fersht, A.R.
登録日	2010-11-04
公開日	2011-03-30
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.68 Å)
主引用文献	Interaction of the P53 DNA-Binding Domain with its N-Terminal Extension Modulates the Stability of the P53 Tetramer. J.Mol.Biol., 409, 2011

2YBG

Structure of Lys120-acetylated p53 core domain
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Arbely, E, Allen, M.D, Joerger, A.C, Fersht, A.R.
登録日	2011-03-08
公開日	2011-05-04
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Acetylation of Lysine 120 of P53 Endows DNA- Binding Specificity at Effective Physiological Salt Concentration. Proc.Natl.Acad.Sci.USA, 108, 2011

2WGX

HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
分子名称:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Khoo, K.H, Fersht, A.R.
登録日	2009-04-27
公開日	2009-05-12
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Stabilising the DNA-Binding Domain of P53 by Rational Design of its Hydrophobic Core. Protein Eng.Des.Sel., 22, 2009

2VUK

Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083
分子名称:	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Joerger, A.C, Boeckler, F.M, Fersht, A.R.
登録日	2008-05-26
公開日	2008-07-22
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug. Proc.Natl.Acad.Sci.USA, 105, 2008

2X0W

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole
分子名称:	5,6-DIMETHOXY-2-METHYL-1,3-BENZOTHIAZOLE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
著者	Kaar, J.L, Basse, N, Joerger, A.C, Fersht, A.R.
登録日	2009-12-17
公開日	2010-01-26
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant. Chem.Biol., 17, 2010

1B27

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-04
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B3S

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-01
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.39 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B2S

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR), SULFATE ION
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-11-30
公開日	1998-12-08
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.82 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

1B2U

STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE
分子名称:	PROTEIN (BARNASE), PROTEIN (BARSTAR)
著者	Vaughan, C.K, Buckle, A.M, Fersht, A.R.
登録日	1998-12-01
公開日	1998-12-09
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999

2C6A

Solution structure of the C4 zinc-finger domain of HDM2
分子名称:	UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
著者	Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
登録日	2005-11-08
公開日	2006-01-04
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006

2C6B

Solution structure of the C4 zinc-finger domain of HDM2
分子名称:	UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION
著者	Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M.
登録日	2005-11-08
公開日	2006-01-04
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006

2FEJ

Solution structure of human p53 DNA binding domain.
分子名称:	Cellular tumor antigen p53, ZINC ION
著者	Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R.
登録日	2005-12-16
公開日	2006-01-31
最終更新日	2022-03-09
実験手法	SOLUTION NMR
主引用文献	Solution structure of p53 core domain: Structural basis for its instability Proc.Natl.Acad.Sci.Usa, 103, 2006

1W4H

Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1JON

GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345
分子名称:	GROEL, HSP60 CLASS
著者	Buckle, A.M, Fersht, A.R.
登録日	1996-05-30
公開日	1997-03-12
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Chaperone activity and structure of monomeric polypeptide binding domains of GroEL. Proc.Natl.Acad.Sci.USA, 93, 1996

1W4J

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	PYRUVATE DEHYDROGENASE E2
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J. Mol. Biol., 353, 2005

1W4G

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions
分子名称:	DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1W4F

Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1W4K

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	PYRUVATE DEHYDROGENASE E2
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1W4E

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1W4I

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions
分子名称:	PYRUVATE DEHYDROGENASE E2
著者	Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R.
登録日	2004-07-23
公開日	2005-07-20
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005

1KCQ

Human Gelsolin Domain 2 with a Cd2+ bound
分子名称:	CADMIUM ION, GELSOLIN
著者	Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R.
登録日	2001-11-09
公開日	2002-01-04
最終更新日	2023-08-16
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9, 2002

1KID

GROEL (HSP60 CLASS) FRAGMENT (APICAL DOMAIN) COMPRISING RESIDUES 191-376, MUTANT WITH ALA 262 REPLACED WITH LEU AND ILE 267 REPLACED WITH MET
分子名称:	GROEL (HSP60 CLASS)
著者	Buckle, A.M, Fersht, A.R.
登録日	1996-12-13
公開日	1997-09-17
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A structural model for GroEL-polypeptide recognition. Proc.Natl.Acad.Sci.USA, 94, 1997

1YPC

DIRECT OBSERVATION OF BETTER HYDRATION AT THE N-TERMINUS OF AN ALPHA-HELIX WITH GLYCINE RATHER THAN ALANINE AS N-CAP
分子名称:	CHYMOTRYPSIN INHIBITOR 2
著者	Harpaz, Y, Elmasry, N, Fersht, A.R, Henrick, K.
登録日	1993-01-10
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue. Proc.Natl.Acad.Sci.USA, 91, 1994

1YPB

DIRECT OBSERVATION OF BETTER HYDRATION AT THE N-TERMINUS OF AN ALPHA-HELIX WITH GLYCINE RATHER THAN ALANINE AS N-CAP
分子名称:	CHYMOTRYPSIN INHIBITOR 2
著者	Harpaz, Y, Elmasry, N, Fersht, A.R, Henrick, K.
登録日	1993-01-10
公開日	1994-01-31
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue. Proc.Natl.Acad.Sci.USA, 91, 1994

<123 4 5 6 >

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