8BC1
| Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN | Descriptor: | Anoctamin-6,mTMEM16F, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-14 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8BC0
| Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-14 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8BEN
| LRR domain Structure of the LRRC8C protein | Descriptor: | Volume-regulated anion channel subunit LRRC8C | Authors: | Sawicka, M, Dutzler, R. | Deposit date: | 2022-10-21 | Release date: | 2022-12-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of a volume-regulated heteromeric LRRC8A/C channel. Nat.Struct.Mol.Biol., 30, 2023
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8C02
| Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation | Descriptor: | Solute carrier family 40 member 1, Sybody3 | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.09 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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8C03
| Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, Solute carrier family 40 member 1 | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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8BZY
| Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ... | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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7QIA
| Structure of apo-EleNRMT in complex with two nanobodies at 3.5A | Descriptor: | Divalent metal cation transporter, Nanobody 1, Nanobody 2 | Authors: | Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C. | Deposit date: | 2021-12-14 | Release date: | 2021-12-29 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. Elife, 11, 2022
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7QIC
| Structure of magnesium-bound EleNRMT in complex with two nanobodies at 4.1A | Descriptor: | Divalent metal cation transporter, MAGNESIUM ION, Nanobody 1, ... | Authors: | Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C. | Deposit date: | 2021-12-14 | Release date: | 2021-12-29 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. Elife, 11, 2022
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7QJI
| X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A | Descriptor: | Divalent metal cation transporter, Elen-Nanobody-complex | Authors: | Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C. | Deposit date: | 2021-12-16 | Release date: | 2022-02-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. Elife, 11, 2022
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7QJJ
| X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A | Descriptor: | Divalent metal cation transporter, Elen-Nb1-Nb2, MANGANESE (II) ION | Authors: | Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C. | Deposit date: | 2021-12-16 | Release date: | 2022-02-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family. Elife, 11, 2022
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5M8K
| Crystal structure of Eremococcus coleocola manganese transporter mutant E129Q | Descriptor: | Divalent metal cation transporter MntH | Authors: | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | Deposit date: | 2016-10-29 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Nat Commun, 8, 2017
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5M8A
| Crystal structure of Eremococcus coleocola manganese transporter mutant E129A | Descriptor: | Divalent metal cation transporter MntH | Authors: | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | Deposit date: | 2016-10-28 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Nat Commun, 8, 2017
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5M87
| Crystal structure of Eremococcus coleocola manganese transporter | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, Divalent metal cation transporter MntH | Authors: | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | Deposit date: | 2016-10-28 | Release date: | 2017-01-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Nat Commun, 8, 2017
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5M8J
| Crystal structure of Eremococcus coleocola manganese transporter mutant H236A | Descriptor: | Divalent metal cation transporter MntH | Authors: | Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R. | Deposit date: | 2016-10-29 | Release date: | 2017-01-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family. Nat Commun, 8, 2017
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5M95
| STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE | Descriptor: | CAMELID ANTIBODY FRAGMENT, NANOBODY, Divalent metal cation transporter MntH, ... | Authors: | Ehrnstorfer, I.A, Geertsma, E.R, Pardon, E, Steyaert, J, Dutzler, R. | Deposit date: | 2016-10-31 | Release date: | 2016-11-30 | Last modified: | 2019-09-25 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure Of A Slc11 (Nramp) Transporter Reveals The Basis For Transition-Metal Ion Transport. Nat.Struct.Mol.Biol., 21, 2014
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2XQ5
| Pentameric ligand gated ion channel GLIC in complex with tetraethylarsonium (TEAs) | Descriptor: | ARSENIC, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ7
| Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+) | Descriptor: | CADMIUM ION, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ8
| Pentameric ligand gated ion channel GLIC in complex with zinc ion (Zn2+) | Descriptor: | GLR4197 PROTEIN, ZINC ION | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ3
| Pentameric ligand gated ion channel GLIC in complex with Br-lidocaine | Descriptor: | BROMIDE ION, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQA
| Pentameric ligand gated ion channel GLIC in complex with tetrabutylantimony (TBSb) | Descriptor: | ANTIMONY (III) ION, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ6
| Pentameric ligand gated ion channel GLIC in complex with cesium ion (Cs+) | Descriptor: | CESIUM ION, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ4
| Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs) | Descriptor: | ARSENIC, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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2XQ9
| Pentameric ligand gated ion channel GLIC mutant E221A in complex with tetraethylarsonium (TEAs) | Descriptor: | ARSENIC, GLR4197 PROTEIN | Authors: | Hilf, R.J.C, Bertozzi, C, Zimmermann, I, Reiter, A, Trauner, D, Dutzler, R. | Deposit date: | 2010-09-01 | Release date: | 2010-11-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel Nat.Struct.Mol.Biol., 17, 2010
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5NL2
| cryo-EM structure of the mTMEM16A ion channel at 6.6 A resolution. | Descriptor: | Anoctamin-1 | Authors: | Paulino, C, Neldner, Y, Lam, K.M, Kalienkova, V, Brunner, J.D, Schenck, S, Dutzler, R. | Deposit date: | 2017-04-03 | Release date: | 2017-06-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. Elife, 6, 2017
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5OYB
| Structure of calcium-bound mTMEM16A chloride channel at 3.75 A resolution | Descriptor: | Anoctamin-1, CALCIUM ION | Authors: | Paulino, C, Kalienkova, V, Lam, K.M, Neldner, Y, Dutzler, R. | Deposit date: | 2017-09-08 | Release date: | 2017-12-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM. Nature, 552, 2017
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