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1M5B
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BU of 1m5b by Molmil
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION.
Descriptor: (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID, Glutamate receptor 2, ZINC ION
Authors:Hogner, A, Kastrup, J.S, Jin, R, Liljefors, T, Mayer, M.L, Egebjerg, J, Larsen, I.K, Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
1M5E
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BU of 1m5e by Molmil
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION
Descriptor: (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID, ACETATE ION, Glutamate receptor 2, ...
Authors:Hogner, A, Kastrup, J.S, Jin, R, Liljefors, T, Mayer, M.L, Egebjerg, J, Larsen, I.K, Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
8TVB
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BU of 8tvb by Molmil
Ghanaian virus fusion glycoprotein (GhV F)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
Authors:Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2023-08-17
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVE
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BU of 8tve by Molmil
Langya henipavirus fusion protein in postfusion state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Langya henipavirus fusion protein in postfusion state
Authors:Wang, Z, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2023-08-18
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVF
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BU of 8tvf by Molmil
Langya henipavirus fusion protein in prefusion state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Langya henipavirus fusion protein in prefusion state, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wang, Z, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2023-08-18
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVG
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BU of 8tvg by Molmil
Langya henipavirus postfusion F protein in complex with the 4G5 Fab, local refinement of the viral membrane distal region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Langya henipavirus postfusion F protein
Authors:Wang, Z, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2023-08-18
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVH
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BU of 8tvh by Molmil
Langya henipavirus postfusion F protein in complex with 4G5 Fab, local refinement of the viral membrane proximal region
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4G5 heavy chain, 4G5 light chain, ...
Authors:Wang, Z, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2023-08-18
Release date:2024-05-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
8VWP
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BU of 8vwp by Molmil
Langya Virus attachment (G) glycoprotein with K85L/L86K mutation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Langya virus attachment (G) protein
Authors:Gibson, C.G, McCallum, M.M, Veesler, D.V, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-02-02
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structure and design of Langya virus glycoprotein antigens.
Proc.Natl.Acad.Sci.USA, 121, 2024
2AL5
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BU of 2al5 by Molmil
Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Descriptor: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
6G25
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BU of 6g25 by Molmil
X-ray structure of NSD3-PWWP1 in complex with compound 4
Descriptor: 3,5-dimethyl-4-(4-pyridin-4-yl-1~{H}-pyrazol-3-yl)-1,2-oxazole, Histone-lysine N-methyltransferase NSD3
Authors:Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2018-03-22
Release date:2019-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.432 Å)
Cite:Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
6G2B
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BU of 6g2b by Molmil
X-ray structure of NSD3-PWWP1 in complex with compound 8
Descriptor: 4-(3-methyl-5-phenyl-imidazol-4-yl)pyridine, Histone-lysine N-methyltransferase NSD3
Authors:Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2018-03-22
Release date:2019-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
6G2O
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BU of 6g2o by Molmil
X-ray structure of NSD3-PWWP1 in complex with compound BI-9321
Descriptor: Histone-lysine N-methyltransferase NSD3, [4-[5-(7-fluoranylquinolin-4-yl)-1-methyl-imidazol-4-yl]-3,5-dimethyl-phenyl]methanamine
Authors:Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2018-03-23
Release date:2019-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
1M5C
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BU of 1m5c by Molmil
X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH Br-HIBO AT 1.65 A RESOLUTION
Descriptor: (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID, Glutamate receptor 2
Authors:Hogner, A, Kastrup, J.S, Jin, R, Liljefors, T, Mayer, M.L, Egebjerg, J, Larsen, I.K, Gouaux, E.
Deposit date:2002-07-09
Release date:2002-09-18
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
J.Mol.Biol., 322, 2002
6G29
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BU of 6g29 by Molmil
X-ray structure of NSD3-PWWP1 in complex with compound 6
Descriptor: 5-methyl-2-piperidin-4-yl-6-pyridin-4-yl-pyridazin-3-one, Histone-lysine N-methyltransferase NSD3
Authors:Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2018-03-22
Release date:2019-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
6G2E
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BU of 6g2e by Molmil
X-ray structure of NSD3-PWWP1 in complex with compound 13
Descriptor: Histone-lysine N-methyltransferase NSD3, [3,5-dimethyl-4-(1-methyl-5-pyridin-4-yl-imidazol-4-yl)phenyl]methanamine
Authors:Boettcher, J, Muellauer, B.J, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2018-03-23
Release date:2019-06-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Nat.Chem.Biol., 15, 2019
2AIX
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BU of 2aix by Molmil
X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at 2.2 a resolution.
Descriptor: (S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID, Glutamate receptor 2
Authors:Kastrup, J.S.
Deposit date:2005-08-01
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Distinct kinetics of ionotropic glutamate receptor 2 splice variants characterized by fast agonist application and crystallization of a receptor-ligand complex.
To be Published
6GJ5
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BU of 6gj5 by Molmil
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 15
Descriptor: (3~{S})-3-[2-[(2~{R})-pyrrolidin-2-yl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ...
Authors:Kessler, D, Mcconnell, D.M, Mantoulidis, A.
Deposit date:2018-05-16
Release date:2019-07-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Drugging an undruggable pocket on KRAS.
Proc.Natl.Acad.Sci.USA, 116, 2019
4Z3L
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BU of 4z3l by Molmil
CRYSTAL STRUCTURE OF BIRCH POLLEN ALLERGEN BET V 1 MUTANT G26L, D69I, P90L, K97I
Descriptor: Major pollen allergen Bet v 1-A, SULFATE ION
Authors:Freier, R, Brandstetter, H.
Deposit date:2015-03-31
Release date:2015-11-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.
J.Allergy Clin.Immunol., 137, 2016
6GJ8
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BU of 6gj8 by Molmil
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852
Descriptor: (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ...
Authors:Kessler, D, Mcconnell, D.M, Mantoulidis, A.
Deposit date:2018-05-16
Release date:2019-07-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Drugging an undruggable pocket on KRAS.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KXA
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BU of 6kxa by Molmil
Galectin-3 CRD binds to GalA dimer
Descriptor: Galectin-3, alpha-D-galactopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid
Authors:Su, J.
Deposit date:2019-09-10
Release date:2020-08-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3.
Glycobiology, 31, 2021
6GJ6
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BU of 6gj6 by Molmil
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 18
Descriptor: (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ...
Authors:Kessler, D, Mcconnell, D.M, Mantoulidis, A, Phan, J.
Deposit date:2018-05-16
Release date:2019-07-31
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Drugging an undruggable pocket on KRAS.
Proc.Natl.Acad.Sci.USA, 116, 2019
6GJ7
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BU of 6gj7 by Molmil
CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 22
Descriptor: (3~{S})-5-oxidanyl-3-[2-[[[1-(phenylmethyl)indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ...
Authors:Kessler, D, Mcconnell, D.M, Mantoulidis, A.
Deposit date:2018-05-16
Release date:2019-07-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Drugging an undruggable pocket on KRAS.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KXB
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BU of 6kxb by Molmil
Galectin-3 CRD binds to GalA trimer
Descriptor: Galectin-3, alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid
Authors:Su, J.
Deposit date:2019-09-10
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Topsy-turvy binding of negatively charged homogalacturonan oligosaccharides to galectin-3.
Glycobiology, 31, 2021
7Z6L
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BU of 7z6l by Molmil
Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Descriptor: (2~{S},4~{R})-~{N}-[[2-[3-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Roy, M.J, Bader, G, Farnaby, W, Ciulli, A.
Deposit date:2022-03-12
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun, 13, 2022
7Z77
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BU of 7z77 by Molmil
Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Descriptor: (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Bader, G, Boettcher, J, Wolkerstorfer, B.
Deposit date:2022-03-15
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun, 13, 2022

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