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4DJU
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BU of 4dju by Molmil
Structure of BACE Bound to 2-imino-3-methyl-5,5-diphenylimidazolidin-4-one
Descriptor: (2E)-2-imino-3-methyl-5,5-diphenylimidazolidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID
Authors:Strickland, C, Cumming, J.
Deposit date:2012-02-02
Release date:2012-03-21
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
4DJX
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BU of 4djx by Molmil
Structure of BACE Bound to 5-(3-(5-chloropyridin-3-yl)phenyl)-5-cyclopropyl-2-imino-3-methylimidazolidin-4-one
Descriptor: (2E,5R)-5-[3-(5-chloropyridin-3-yl)phenyl]-5-cyclopropyl-2-imino-3-methylimidazolidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID
Authors:Strickland, C, Cumming, J.
Deposit date:2012-02-02
Release date:2012-03-21
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
4DJY
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BU of 4djy by Molmil
Structure of BACE Bound to (R)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one
Descriptor: (2E,5R)-5-cyclopropyl-2-imino-3-methyl-5-{3-[5-(prop-1-yn-1-yl)pyridin-3-yl]phenyl}imidazolidin-4-one, Beta-secretase 1, L(+)-TARTARIC ACID
Authors:Strickland, C, Cumming, J.
Deposit date:2012-02-02
Release date:2012-03-21
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.
Bioorg.Med.Chem.Lett., 22, 2012
6V9C
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BU of 6v9c by Molmil
Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor
Descriptor: Fibroblast growth factor receptor 4, N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide, SULFATE ION
Authors:Liu, J, Liu, H.
Deposit date:2019-12-13
Release date:2020-03-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Acs Med.Chem.Lett., 11, 2020
7AEL
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BU of 7ael by Molmil
alpha 1-antitrypsin (C232S) complexed with GSK716
Descriptor: Alpha-1-antitrypsin, SULFATE ION, ~{N}-[(1~{S},2~{R})-1-(3-fluoranyl-2-methyl-phenyl)-1-oxidanyl-pentan-2-yl]-2-oxidanylidene-1,3-dihydroindole-4-carboxamide
Authors:Chung, C.
Deposit date:2020-09-17
Release date:2021-03-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Development of a small molecule that corrects misfolding and increases secretion of Z alpha 1 -antitrypsin.
Embo Mol Med, 13, 2021
3S1S
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BU of 3s1s by Molmil
Characterization and crystal structure of the type IIG restriction endonuclease BpuSI
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, MANGANESE (II) ION, ...
Authors:Shen, B.W, Xu, D, Chan, S.-H, Zheng, Y, Zhu, Y, Xu, S.-Y, Stoddard, B.L.
Deposit date:2011-05-16
Release date:2011-07-13
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI.
Nucleic Acids Res., 39, 2011
7OBQ
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BU of 7obq by Molmil
SRP-SR at the distal site conformation
Descriptor: EM14S01-3B_G0054400.mRNA.1.CDS.1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Jomaa, A, Ban, N.
Deposit date:2021-04-23
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
Cell Rep, 36, 2021
7OBR
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BU of 7obr by Molmil
RNC-SRP early complex
Descriptor: 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Jomaa, A, Ban, N.
Deposit date:2021-04-23
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
Cell Rep, 36, 2021
5BT1
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BU of 5bt1 by Molmil
histone chaperone Hif1 playing with histone H2A-H2B dimer
Descriptor: HAT1-interacting factor 1, Histone H2A.1, Histone H2B.1
Authors:Liu, H, Zhang, M, Gao, Y, Teng, M, Niu, L.
Deposit date:2015-06-02
Release date:2016-10-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer
Structure, 24, 2016
6LE6
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BU of 6le6 by Molmil
Structure of LNLPTQGRAR bound FEM1C
Descriptor: Protein fem-1 homolog C,10-mer peptide, SULFATE ION
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-24
Release date:2020-10-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6LBF
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BU of 6lbf by Molmil
Crystal structure of FEM1B
Descriptor: Protein fem-1 homolog B, SULFATE ION
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-14
Release date:2020-10-21
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.252 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6L8F
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BU of 6l8f by Molmil
Crystal structure of heterotetrameric complex of YoeB-YefM toxin-antitoxin from Staphylococcus aureus.
Descriptor: Antitoxin, YoeB
Authors:Yue, J, Xue, L.
Deposit date:2019-11-06
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system.
Nucleic Acids Res., 48, 2020
6LDP
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BU of 6ldp by Molmil
Structure of CDK5R1-bound FEM1C
Descriptor: Protein fem-1 homolog C,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-22
Release date:2020-10-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6LEN
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BU of 6len by Molmil
Structure of NS11 bound FEM1C
Descriptor: Protein fem-1 homolog C,NS11 peptide
Authors:Chen, x, Liao, S, Xu, C.
Deposit date:2019-11-25
Release date:2020-10-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.383 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6L8E
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BU of 6l8e by Molmil
Crystal structure of heterohexameric YoeB-YefM complex bound to 26bp-DNA
Descriptor: DNA (26-mer), YefM Antitoxin, YoeB toxin
Authors:Yue, J, Xue, L.
Deposit date:2019-11-06
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system.
Nucleic Acids Res., 48, 2020
6LF0
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BU of 6lf0 by Molmil
Structure of FEM1C
Descriptor: Protein fem-1 homolog C, SULFATE ION
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-27
Release date:2020-10-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6LBN
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BU of 6lbn by Molmil
Structure of SIL1-bound FEM1C
Descriptor: Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-14
Release date:2020-10-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
6LEY
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BU of 6ley by Molmil
Structure of Sil1G bound FEM1C
Descriptor: Protein fem-1 homolog C,Peptide from Nucleotide exchange factor SIL1
Authors:Chen, X, Liao, S, Xu, C.
Deposit date:2019-11-27
Release date:2020-10-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
1HQZ
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BU of 1hqz by Molmil
Cofilin homology domain of a yeast actin-binding protein ABP1P
Descriptor: ACTIN-BINDING PROTEIN
Authors:Strokopytov, B.V, Fedorov, A.A, Mahoney, N, Drubin, D.G, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2000-12-20
Release date:2001-12-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches.
Acta Crystallogr.,Sect.D, 61, 2005
7SS8
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BU of 7ss8 by Molmil
Human P300 complexed with a proline-based inhibitor
Descriptor: 1,2-ETHANEDIOL, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-{[3-(methylcarbamoyl)phenyl]methyl}-D-prolinamide, Histone acetyltransferase p300, ...
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-10
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
7SZQ
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BU of 7szq by Molmil
Human P300 complexed with an azaindazole inhibitor
Descriptor: 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide, Histone acetyltransferase p300
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
7SSK
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BU of 7ssk by Molmil
Human P300 complexed with a glycine-based inhibitor
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Histone acetyltransferase p300, ...
Authors:Shewchuk, L.M, Reid, R.A.
Deposit date:2021-11-11
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
7JL3
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BU of 7jl3 by Molmil
Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ...
Authors:Kato, K, Ahmad, S, Hur, S.
Deposit date:2020-07-29
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
7JL0
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BU of 7jl0 by Molmil
Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ...
Authors:Kato, K, Ahmad, S, Hur, S.
Deposit date:2020-07-29
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021
7JL1
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BU of 7jl1 by Molmil
Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ...
Authors:Kato, K, Ahmad, S, Hur, S.
Deposit date:2020-07-29
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Mol.Cell, 81, 2021

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