7V5J
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![BU of 7v5j by Molmil](/molmil-images/mine/7v5j) | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-17 | Release date: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) to be published
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7V6N
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![BU of 7v6n by Molmil](/molmil-images/mine/7v6n) | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | Descriptor: | 111 H, 111 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-20 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 to be published
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7V6O
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![BU of 7v6o by Molmil](/molmil-images/mine/7v6o) | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | Descriptor: | 111 H, 111 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-20 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (4.56 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) to be published
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7XMK
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![BU of 7xmk by Molmil](/molmil-images/mine/7xmk) | Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923 | Descriptor: | 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Zhang, L, Wang, Y, Li, Y, Yang, S. | Deposit date: | 2022-04-26 | Release date: | 2023-04-26 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.376 Å) | Cite: | From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases. J.Med.Chem., 67, 2024
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7XZ4
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![BU of 7xz4 by Molmil](/molmil-images/mine/7xz4) | |
7VI6
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![BU of 7vi6 by Molmil](/molmil-images/mine/7vi6) | Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila | Descriptor: | Beta-N-acetylhexosaminidase, CHLORIDE ION, MAGNESIUM ION | Authors: | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | Deposit date: | 2021-09-26 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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7VI7
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![BU of 7vi7 by Molmil](/molmil-images/mine/7vi7) | Crystal structure of GH3 beta-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila in complex with GlcNAc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | Authors: | Qian, K, Yang, W, Chen, X, Wang, Y, Zhang, M, Wang, M. | Deposit date: | 2021-09-26 | Release date: | 2021-12-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of a GH3 beta-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation Biochem.Biophys.Res.Commun., 589, 2022
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7VOO
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![BU of 7voo by Molmil](/molmil-images/mine/7voo) | Induced alpha-2-macroglobulin monomer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Huang, X, Wang, Y, Ping, Z. | Deposit date: | 2021-10-14 | Release date: | 2022-10-19 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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7X63
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![BU of 7x63 by Molmil](/molmil-images/mine/7x63) | SARS-CoV-2-Beta-RBD and BD-236-GWP/P-VK antibody complex | Descriptor: | BD-236 Fab heavy chain, BD-236 Fab light chain, Spike protein S1 | Authors: | Shi, R, Wang, Y, Wu, Z, Han, X, Yan, J. | Deposit date: | 2022-03-06 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | SARS-CoV-2-Beta-RBD and BD-236-GWP/P-VK antibody complex To Be Published
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7XIK
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![BU of 7xik by Molmil](/molmil-images/mine/7xik) | SARS-CoV-2-Omicron-RBD and B38-GWP/P-VK antibody complex | Descriptor: | B38 Fab heavy chain, B38 Fab light chain, Spike protein S1 | Authors: | Shi, R, Wang, Y, Wu, Z, Han, X, Yan, J. | Deposit date: | 2022-04-13 | Release date: | 2023-04-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | SARS-CoV-2-Omicron-RBD and B38-GWP/P-VK antibody complex To Be Published
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7XIL
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![BU of 7xil by Molmil](/molmil-images/mine/7xil) | SARS-CoV-2-Beta-RBD and B38-GWP/P-VK antibody complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, B38 Fab heavy chain, B38 Fab light chain, ... | Authors: | Shi, R, Wang, Y, Wu, Z, Han, X, Yan, J. | Deposit date: | 2022-04-13 | Release date: | 2023-04-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | SARS-CoV-2-Beta-RBD and B38-GWP/P-VK antibody complex To Be Published
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7X66
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![BU of 7x66 by Molmil](/molmil-images/mine/7x66) | SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex | Descriptor: | BD-236 Fab heavy chain, BD-236 Fab light chain, Spike protein S1 | Authors: | Shi, R, Wang, Y, Wu, Z, Han, X, Yan, J. | Deposit date: | 2022-03-06 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | SARS-CoV-2-Omicron-RBD and BD-236-GWP/P-VK antibody complex To Be Published
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7X4Y
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![BU of 7x4y by Molmil](/molmil-images/mine/7x4y) | Crystal structure of Bacteroides thetaiotaomicron glutamate decarboxylase BTGAD-PLP-GABA complex | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glutamate decarboxylase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Liu, S, Du, G, Wang, Y, Wen, B, Xin, F. | Deposit date: | 2022-03-03 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple elements under different pH. Food Chem, 403, 2023
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7X52
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![BU of 7x52 by Molmil](/molmil-images/mine/7x52) | Crystal structure of Bacteroides thetaiotaomicron glutamate decarboxylase BTGAD-PLP complex | Descriptor: | ACETATE ION, Glutamate decarboxylase, MALONATE ION, ... | Authors: | Liu, S, Du, G, Wang, Y, Wen, B, Xin, F. | Deposit date: | 2022-03-03 | Release date: | 2023-04-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Coordinated regulation of Bacteroides thetaiotaomicron glutamate decarboxylase activity by multiple elements under different pH. Food Chem, 403, 2023
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7YL0
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![BU of 7yl0 by Molmil](/molmil-images/mine/7yl0) | Structure of hIAPP-TF-type2 | Descriptor: | Islet amyloid polypeptide | Authors: | Li, D, Zhang, X, Wang, Y, Zhu, P. | Deposit date: | 2022-07-25 | Release date: | 2022-12-28 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core. Iscience, 25, 2022
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7YKW
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![BU of 7ykw by Molmil](/molmil-images/mine/7ykw) | |
7VON
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![BU of 7von by Molmil](/molmil-images/mine/7von) | Native alpha-2-macroglobulin monomer | Descriptor: | Alpha-2-macroglobulin | Authors: | Huang, X, Wang, Y. | Deposit date: | 2021-10-14 | Release date: | 2022-11-16 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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6OVB
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![BU of 6ovb by Molmil](/molmil-images/mine/6ovb) | Crystal structure of a Bacillus thuringiensis Cry1Da tryptic core variant | Descriptor: | Active core crystal toxin protein 1D | Authors: | Rydel, T.J, Halls, C, Evdokimov, A.G, Beishir, S.C. | Deposit date: | 2019-05-07 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.611 Å) | Cite: | Bacillus thuringiensis Cry1Da_7 and Cry1B.868 Protein Interactions with Novel Receptors Allow Control of Resistant Fall Armyworms, Spodoptera frugiperda (J.E. Smith). Appl.Environ.Microbiol., 85, 2019
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7YMK
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![BU of 7ymk by Molmil](/molmil-images/mine/7ymk) | Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with an Covalent Selective Estrogen Receptor Degrader 29c and GRIP Peptide | Descriptor: | DI(HYDROXYETHYL)ETHER, Estrogen receptor, Grip peptide, ... | Authors: | Min, J, Hu, H.B, Yang, Y, Dong, C.E, Zhou, H.B, Chen, C.-C, Guo, R.-T. | Deposit date: | 2022-07-28 | Release date: | 2023-05-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer. Acta Pharm Sin B, 13, 2023
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9IJB
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![BU of 9ijb by Molmil](/molmil-images/mine/9ijb) | Crystal structure and function analysis of a highly potential drug target 6-phosphogluconate dehydrogenase in Mycobacterium tuberculosis | Descriptor: | 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating | Authors: | Wang, Y.Z, Ren, X.Q, Li, T, Zhang, R.D. | Deposit date: | 2024-06-22 | Release date: | 2024-07-03 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.740405 Å) | Cite: | Crystal structure and function analysis of 6-phosphogluconate dehydrogenase in Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 731, 2024
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3RYT
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![BU of 3ryt by Molmil](/molmil-images/mine/3ryt) | The Plexin A1 intracellular region in complex with Rac1 | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-A1, ... | Authors: | Zhang, X, He, H. | Deposit date: | 2011-05-11 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.582 Å) | Cite: | Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization. Sci.Signal., 5, 2012
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8GUN
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![BU of 8gun by Molmil](/molmil-images/mine/8gun) | |
8GUP
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![BU of 8gup by Molmil](/molmil-images/mine/8gup) | Crystal structure of EsaG from Staphylococcus aureus | Descriptor: | CITRIC ACID, Type VII secretion system protein EsaG | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2022-09-13 | Release date: | 2022-11-09 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.298725 Å) | Cite: | A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria. Nat Commun, 13, 2022
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8GUO
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![BU of 8guo by Molmil](/molmil-images/mine/8guo) | |
4O9S
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![BU of 4o9s by Molmil](/molmil-images/mine/4o9s) | Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]-2-[2-(trifluoromethyl)phenyl]ethanone, CHLORIDE ION, ... | Authors: | Wang, Z, Johnstone, S, Walker, N.P. | Deposit date: | 2014-01-02 | Release date: | 2014-07-02 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg.Med.Chem.Lett., 24, 2014
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