9GIP
 
 | | BFL1 covalently bound to inhibitor compound 7 | | Descriptor: | Bcl-2-related protein A1, ~{N}-[4-[(1~{R},3~{R})-3-azanylcyclopentyl]oxyphenyl]-~{N}-[(1~{S})-1-(4-chlorophenyl)ethyl]propanamide | | Authors: | Hargreaves, D, Cottee, M.A. | | Deposit date: | 2024-08-19 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (1.463 Å) | | Cite: | Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
J.Med.Chem., 67, 2024
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9GIT
 | | BFL1 covalently bound to inhibitor compound 43 | | Descriptor: | (3~{S})-3-[[4-[(1~{R},3~{R})-3-[[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]carbamoylamino]cyclopentyl]oxy-3-fluoranyl-phenyl]-propanoyl-amino]-3-(4-chlorophenyl)propanamide, Bcl-2-related protein A1 | | Authors: | Cottee, M.A. | | Deposit date: | 2024-08-19 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (1.145 Å) | | Cite: | Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
J.Med.Chem., 67, 2024
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9GIS
 | | BFL1 covalently bound to inhibitor compound 17 | | Descriptor: | Bcl-2-related protein A1, ~{N}-[(1~{S})-1-(4-chlorophenyl)ethyl]-~{N}-[4-[(1~{R},3~{R})-3-[[(3~{S})-pyrrolidin-3-yl]carbamoylamino]cyclopentyl]oxyphenyl]propanamide | | Authors: | Cottee, M.A. | | Deposit date: | 2024-08-19 | | Release date: | 2024-12-18 | | Last modified: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (1.387 Å) | | Cite: | Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors.
J.Med.Chem., 67, 2024
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8JMI
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8JM9
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8JMA
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8JME
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8JMH
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9GIO
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8IRL
 | | Apo state of Arabidopsis AZG1 at pH 7.4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1 | | Authors: | Xu, L, Guo, J. | | Deposit date: | 2023-03-19 | | Release date: | 2024-01-17 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
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8IRN
 | | 6-BAP bound state of Arabidopsis AZG1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1, N-BENZYL-9H-PURIN-6-AMINE | | Authors: | Xu, L, Guo, J. | | Deposit date: | 2023-03-19 | | Release date: | 2024-01-17 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
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8IRP
 | | kinetin bound state of Arabidopsis AZG1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1, N-(FURAN-2-YLMETHYL)-7H-PURIN-6-AMINE | | Authors: | Xu, L, Guo, J. | | Deposit date: | 2023-03-19 | | Release date: | 2024-01-17 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
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8IRM
 | | Endogenous substrate adenine bound state of Arabidopsis AZG1 at pH 5.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Adenine/guanine permease AZG1 | | Authors: | Xu, L, Guo, J. | | Deposit date: | 2023-03-19 | | Release date: | 2024-01-17 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
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8IRO
 | | trans-Zeatin bound state of Arabidopsis AZG1 at pH7.4 | | Descriptor: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1 | | Authors: | Xu, L, Guo, J. | | Deposit date: | 2023-03-19 | | Release date: | 2024-01-17 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
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9J38
 | | human KCNQ5-CaM in apo state | | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 5 | | Authors: | Yang, Z, Guo, J. | | Deposit date: | 2024-08-08 | | Release date: | 2025-04-16 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9LJ5
 | | Human KCNQ5-CaM-PIP2-HN37 complex in an open conformation. | | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | | Authors: | Yang, Z, Guo, J. | | Deposit date: | 2025-01-14 | | Release date: | 2025-04-16 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9LIZ
 | | Human KCNQ5-CaM in complex with PIP2 | | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Yang, Z, Guo, J. | | Deposit date: | 2025-01-14 | | Release date: | 2025-04-16 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.
Proc.Natl.Acad.Sci.USA, 122, 2025
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6LG2
 | | VanR bound to Vanillate | | Descriptor: | 4-HYDROXY-3-METHOXYBENZOATE, Predicted transcriptional regulators | | Authors: | He, Y, Bharath, S.R, Song, H. | | Deposit date: | 2019-12-04 | | Release date: | 2020-02-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps.
Nat Commun, 11, 2020
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3U4U
 | | Casein kinase 2 in complex with AZ-Inhibitor | | Descriptor: | 3-{5-(acetylamino)-3-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]-1H-indol-1-yl}propanoic acid, CHLORIDE ION, Casein kinase II subunit alpha | | Authors: | Larsen, N.A, Dowling, J. | | Deposit date: | 2011-10-10 | | Release date: | 2012-08-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
ACS Med Chem Lett, 3, 2012
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