6LU6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lu6 by Molmil](/molmil-images/mine/6lu6) | Crystal structure of BPTF-BRD with ligand DCBPin5-2 bound | Descriptor: | 6-[1-[3-(dimethylamino)propyl]indol-5-yl]-2-methylsulfonyl-N-propyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | Authors: | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | Deposit date: | 2020-01-26 | Release date: | 2021-04-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.970063 Å) | Cite: | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
|
|
3KXT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kxt by Molmil](/molmil-images/mine/3kxt) | Crystal structure of Sulfolobus Cren7-dsDNA complex | Descriptor: | 5'-D(*GP*CP*GP*AP*TP*CP*GP*C)-3', Chromatin protein Cren7 | Authors: | Feng, Y, Wang, J. | Deposit date: | 2009-12-03 | Release date: | 2010-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.602 Å) | Cite: | Crystal structure of the crenarchaeal conserved chromatin protein Cren7 and double-stranded DNA complex Protein Sci., 19, 2010
|
|
1NJ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nj1 by Molmil](/molmil-images/mine/1nj1) | Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to cysteine sulfamoyl adenylate | Descriptor: | 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ... | Authors: | Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A. | Deposit date: | 2002-12-30 | Release date: | 2003-03-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
5FKP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5fkp by Molmil](/molmil-images/mine/5fkp) | Crystal structure of the mouse CD1d in complex with the p99 peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIGEN-PRESENTING GLYCOPROTEIN CD1D1, BETA 2 MICROGLOBULIN, ... | Authors: | Girardi, E, Wang, J, Zajonc, D.M. | Deposit date: | 2015-10-18 | Release date: | 2016-03-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of an Alpha-Helical Peptide and Lipopeptide Bound to the Non-Classical Mhc Class I Molecule Cd1D J.Biol.Chem., 291, 2016
|
|
1NJ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nj5 by Molmil](/molmil-images/mine/1nj5) | Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to proline sulfamoyl adenylate | Descriptor: | '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ... | Authors: | Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A. | Deposit date: | 2002-12-30 | Release date: | 2003-03-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
1NJ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nj8 by Molmil](/molmil-images/mine/1nj8) | Crystal Structure of Prolyl-tRNA Synthetase from Methanocaldococcus janaschii | Descriptor: | Proline-tRNA Synthetase | Authors: | Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A. | Deposit date: | 2002-12-30 | Release date: | 2003-03-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
5EFI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5efi by Molmil](/molmil-images/mine/5efi) | Crystal structure of mouse CD1d in complex with the p99p lipopeptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Girardi, E, Wang, J, Zajonc, D.M. | Deposit date: | 2015-10-23 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of an alpha-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d. J.Biol.Chem., 291, 2016
|
|
1NGM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ngm by Molmil](/molmil-images/mine/1ngm) | Crystal structure of a yeast Brf1-TBP-DNA ternary complex | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*AP*CP*AP*TP*TP*TP*TP*TP*TP*TP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*AP*AP*AP*AP*AP*AP*AP*TP*GP*TP*TP*TP*TP*TP*T)-3', Transcription factor IIIB BRF1 subunit, ... | Authors: | Juo, Z.S, Kassavetis, G.A, Wang, J, Geiduschek, E.P, Sigler, P.B. | Deposit date: | 2002-12-17 | Release date: | 2003-03-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Crystal structure of a transcription factor IIIB core interface ternary complex Nature, 422, 2003
|
|
5ZAL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zal by Molmil](/molmil-images/mine/5zal) | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | Descriptor: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | Authors: | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | Deposit date: | 2018-02-07 | Release date: | 2018-05-09 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
|
|
8PYI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pyi by Molmil](/molmil-images/mine/8pyi) | Human IGF1R with inhibitor 6 | Descriptor: | 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol, Insulin-like growth factor 1 receptor beta chain | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Human IGF1R with inhibitor 6 To Be Published
|
|
8PYJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pyj by Molmil](/molmil-images/mine/8pyj) | Human IGF1R with inhibitor 8 | Descriptor: | 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Human IGF1R with inhibitor 8 To Be Published
|
|
8PYK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pyk by Molmil](/molmil-images/mine/8pyk) | Human IGF1R with inhibitor 47 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor beta chain, NICKEL (II) ION | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Human IGF1R with inhibitor 47 To Be Published
|
|
8PYN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pyn by Molmil](/molmil-images/mine/8pyn) | Human IGF1R with inhibitor 56 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Human IGF1R with inhibitor 56 To Be Published
|
|
8PYL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pyl by Molmil](/molmil-images/mine/8pyl) | Human IGF1R with inhibitor 53 | Descriptor: | (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Human IGF1R with inhibitor 53 To Be Published
|
|
8PYM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pym by Molmil](/molmil-images/mine/8pym) | Human IGF1R with inhibitor 54 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Human IGF1R with inhibitor 54 To Be Published
|
|
5ZAK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zak by Molmil](/molmil-images/mine/5zak) | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | Descriptor: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 | Authors: | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | Deposit date: | 2018-02-07 | Release date: | 2018-05-09 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
|
|
4JFB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4jfb by Molmil](/molmil-images/mine/4jfb) | Crystal structure of OmpF in C2 with tNCS | Descriptor: | Outer membrane protein F | Authors: | Wiseman, B, Kilburg, A, Chaptal, V, Reyes-Meija, G.C, Sarwan, J, Falson, P, Jault, J.M. | Deposit date: | 2013-02-28 | Release date: | 2014-03-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.801 Å) | Cite: | Stubborn contaminants: influence of detergents on the purity of the multidrug ABC transporter BmrA PLoS ONE, 9, 2014
|
|
1NJ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nj6 by Molmil](/molmil-images/mine/1nj6) | Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to alanine sulfamoyl adenylate | Descriptor: | '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ... | Authors: | Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A. | Deposit date: | 2002-12-30 | Release date: | 2003-03-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Proc.Natl.Acad.Sci.USA, 100, 2003
|
|
3IGI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3igi by Molmil](/molmil-images/mine/3igi) | Tertiary Architecture of the Oceanobacillus Iheyensis Group II Intron | Descriptor: | 5'-R(*CP*GP*CP*UP*CP*UP*AP*CP*UP*CP*UP*AP*U)-3', Group IIC intron, MAGNESIUM ION, ... | Authors: | Toor, N, Keating, K.S, Fedorova, O, Rajashankar, K, Wang, J, Pyle, A.M. | Deposit date: | 2009-07-27 | Release date: | 2009-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.125 Å) | Cite: | Tertiary architecture of the Oceanobacillus iheyensis group II intron. Rna, 16, 2010
|
|
4N77
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n77 by Molmil](/molmil-images/mine/4n77) | |
3MNM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mnm by Molmil](/molmil-images/mine/3mnm) | Crystal structure of GAE domain of GGA2p from Saccharomyces cerevisiae | Descriptor: | ADP-ribosylation factor-binding protein GGA2, GLYCEROL, SULFATE ION | Authors: | Fang, P, Wang, J, Li, X, Niu, L, Teng, M. | Deposit date: | 2010-04-21 | Release date: | 2010-09-08 | Last modified: | 2014-03-05 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5 Biochemistry, 49, 2010
|
|
4EAL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4eal by Molmil](/molmil-images/mine/4eal) | Co-crystal of AMPK core with ATP soaked with AMP | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W. | Deposit date: | 2012-03-22 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | AMP-activated protein kinase undergoes nucleotide-dependent conformational changes Nat.Struct.Mol.Biol., 19, 2012
|
|
3F4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3f4m by Molmil](/molmil-images/mine/3f4m) | Crystal structure of TIPE2 | Descriptor: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | Authors: | Zhang, X, Wang, J, Shi, Y. | Deposit date: | 2008-11-01 | Release date: | 2009-03-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.696 Å) | Cite: | Crystal structure of TIPE2 provides insights into immune homeostasis Nat.Struct.Mol.Biol., 16, 2009
|
|
2KMI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2kmi by Molmil](/molmil-images/mine/2kmi) | |
2O52
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2o52 by Molmil](/molmil-images/mine/2o52) | Crystal structure of human RAB4B in complex with GDP | Descriptor: | BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhu, H, Tempel, W, Wang, J, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-05 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of human RAB4B in complex with GDP To be Published
|
|