4UP4
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![BU of 4up4 by Molmil](/molmil-images/mine/4up4) | Structure of the recombinant lectin PVL from Psathyrella velutina in complex with GlcNAcb-D-1,3Galactoside | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... | Authors: | Audfray, A, Beljoudi, M, Hurbin, A, Varrot, A, Breiman, A, Busser, B, Lependu, J, Coll, J.L, Imberty, A. | Deposit date: | 2014-06-12 | Release date: | 2015-01-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells. Plos One, 10, 2015
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4I6S
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![BU of 4i6s by Molmil](/molmil-images/mine/4i6s) | Structure of RSL mutant W76A in complex with L-fucose | Descriptor: | 1,2-ETHANEDIOL, Putative fucose-binding lectin protein, TETRAETHYLENE GLYCOL, ... | Authors: | Audfray, A, Arnaud, J, Varrot, A, Imberty, A. | Deposit date: | 2012-11-30 | Release date: | 2013-07-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Reduction of lectin valency drastically changes glycolipid dynamics in membranes but not surface avidity Acs Chem.Biol., 8, 2013
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6A3H
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![BU of 6a3h by Molmil](/molmil-images/mine/6a3h) | 2-DEOXY-2-FLURO-B-D-CELLOTRIOSYL/ENZYME INTERMEDIATE COMPLEX OF THE ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHEARANS AT 1.6 ANGSTROM RESOLUTION | Descriptor: | ENDOGLUCANASE, GLYCEROL, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose | Authors: | Davies, G.J, Varrot, A, Dauter, M, Brzozowski, A.M, Schulein, M, Mackenzie, L, Withers, S.G. | Deposit date: | 1998-07-22 | Release date: | 1999-07-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase. Biochemistry, 37, 1998
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4UOU
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![BU of 4uou by Molmil](/molmil-images/mine/4uou) | Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) - apo-form | Descriptor: | DI(HYDROXYETHYL)ETHER, FUCOSE-SPECIFIC LECTIN FLEA | Authors: | Houser, J, Komarek, J, Cioci, G, Varrot, A, Imberty, A, Wimmerova, M. | Deposit date: | 2014-06-10 | Release date: | 2015-03-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insights Into Aspergillus Fumigatus Lectin Specificity: Afl Binding Sites are Functionally Non-Equivalent. Acta Crystallogr.,Sect.D, 71, 2015
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7OLN
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![BU of 7oln by Molmil](/molmil-images/mine/7oln) | |
6GXR
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![BU of 6gxr by Molmil](/molmil-images/mine/6gxr) | Crystal structure of BP39L lectin from Burkholderia pseudomallei at 1.7 A resolution | Descriptor: | BP39L lectin, SULFATE ION | Authors: | Sykorova, P, Novotna, J, Demo, G, Pompidor, G, Dubska, E, Komarek, J, Fujdiarova, E, Haronikova, L, Varrot, A, Imberty, A, Shilova, N, Bovin, N, Pokorna, M, Wimmerova, M. | Deposit date: | 2018-06-27 | Release date: | 2019-12-04 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold. Int.J.Biol.Macromol., 152, 2020
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7QE3
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![BU of 7qe3 by Molmil](/molmil-images/mine/7qe3) | Se-M variant of B-trefoil lectin from Salpingoeca rosetta in complex with GalNAc | Descriptor: | (2S)-hexane-1,2,6-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Notova, S, Varrot, A. | Deposit date: | 2021-12-01 | Release date: | 2022-09-14 | Last modified: | 2022-09-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3. Commun Biol, 5, 2022
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7QE4
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![BU of 7qe4 by Molmil](/molmil-images/mine/7qe4) | B-trefoil lectin from Salpingoeca rosetta in complex with GalNAc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-galactopyranose, CHLORIDE ION, ... | Authors: | Notova, S, Varrot, A. | Deposit date: | 2021-12-01 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3. Commun Biol, 5, 2022
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7R55
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![BU of 7r55 by Molmil](/molmil-images/mine/7r55) | B-trefoil lectin from Salpingoeca rosetta in complex with Gb3 | Descriptor: | 1,2-ETHANEDIOL, Sarol-1, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Notova, S, Varrot, A. | Deposit date: | 2022-02-10 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3. Commun Biol, 5, 2022
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4USP
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![BU of 4usp by Molmil](/molmil-images/mine/4usp) | X-ray structure of the dimeric CCL2 lectin in native form | Descriptor: | CCL2 LECTIN, CHLORIDE ION, PHOSPHATE ION | Authors: | Bleuler-Martinez, S, Varrot, A, Schubert, M, Stutz, M, Sieber, R, Hengartner, M, Aebi, M, Kunzler, M. | Deposit date: | 2014-07-11 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes. Glycobiology, 27, 2017
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4USO
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![BU of 4uso by Molmil](/molmil-images/mine/4uso) | X-ray structure of the CCL2 lectin in complex with sialyl lewis X | Descriptor: | CCL2 LECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Bleuler-Martinez, S, Varrot, A, Schubert, M, Stutz, M, Sieber, R, Hengartner, M, Aebi, M, Kunzler, M. | Deposit date: | 2014-07-11 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes. Glycobiology, 27, 2017
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6YOH
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![BU of 6yoh by Molmil](/molmil-images/mine/6yoh) | LecA from Pseudomonas aeruginosa in complex with a catechol CAS no. 61445-50-9 | Descriptor: | CALCIUM ION, PA-I galactophilic lectin, [2,4-bis(oxidanyl)phenyl]-[3,4-bis(oxidanyl)phenyl]methanone | Authors: | Kuhaudomlarp, S, Imberty, A, Titz, A, Varrot, A. | Deposit date: | 2020-04-14 | Release date: | 2021-02-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-binding Lectins. Angew.Chem.Int.Ed.Engl., 2020
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8QK1
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![BU of 8qk1 by Molmil](/molmil-images/mine/8qk1) | |
8R8A
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![BU of 8r8a by Molmil](/molmil-images/mine/8r8a) | |
6R35
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![BU of 6r35 by Molmil](/molmil-images/mine/6r35) | Structure of the LecB lectin from Pseudomonas aeruginosa strain PAO1 in complex with lewis x tetrasaccharide | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Fucose-binding lectin PA-IIL, ... | Authors: | Lepsik, M, Sommer, R, Kuhaudomlarp, S, Lelimousin, M, Varrot, A, Titz, A, Imberty, A. | Deposit date: | 2019-03-19 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study. Eur.J.Med.Chem., 177, 2019
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5FRA
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![BU of 5fra by Molmil](/molmil-images/mine/5fra) | CBM40_CPF0721-6'SL | Descriptor: | ACETATE ION, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ... | Authors: | Ribeiro, J.P, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A. | Deposit date: | 2015-12-16 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form. Biochem.J., 473, 2016
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5FSC
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![BU of 5fsc by Molmil](/molmil-images/mine/5fsc) | Structure of tectonin 2 from Laccaria bicolor in complex with allyl- alpha_4-methyl-mannoside | Descriptor: | MAGNESIUM ION, TECTONIN 2, prop-2-en-1-yl 4-O-methyl-alpha-D-mannopyranoside | Authors: | Sommer, R, Bleuer, S, Titz, A, Kunzler, M, Varrot, A. | Deposit date: | 2016-01-04 | Release date: | 2017-03-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense. Structure, 26, 2018
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5G3L
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![BU of 5g3l by Molmil](/molmil-images/mine/5g3l) | ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER COMPLEXED WITH SIALYLATED SUGAR | Descriptor: | HEAT-LABILE ENTEROTOXIN IIB, B CHAIN, N-acetyl-alpha-neuraminic acid, ... | Authors: | Zalem, D, Benktander, J, Ribeiro, J.P, Varrot, A, Lebens, M, Imberty, A, Teneberg, S. | Deposit date: | 2016-04-29 | Release date: | 2016-09-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Biochemical and Structural Characterization of the Novel Sialic Acid-Binding Site of Escherichia Coli Heat-Labile Enterotoxin Lt-Iib. Biochem.J., 473, 2016
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5FRE
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![BU of 5fre by Molmil](/molmil-images/mine/5fre) | Characterization of a novel CBM from Clostridium perfringens | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, CALCIUM ION, ... | Authors: | Ribeiro, J, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A. | Deposit date: | 2015-12-17 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form. Biochem.J., 473, 2016
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5FSB
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![BU of 5fsb by Molmil](/molmil-images/mine/5fsb) | Structure of tectonin 2 from laccaria bicolor in complex with 2-o-methyl-methyl-seleno-beta-l-fucopyranoside | Descriptor: | BORIC ACID, MAGNESIUM ION, SULFATE ION, ... | Authors: | Sommer, R, Bleuer, S, Titz, A, Kunzler, M, Varrot, A. | Deposit date: | 2016-01-04 | Release date: | 2017-03-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense. Structure, 26, 2018
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1E5J
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![BU of 1e5j by Molmil](/molmil-images/mine/1e5j) | ENDOGLUCANASE CEL5A FROM BACILLUS AGARADHAERENS IN THE TETRAGONAL CRYSTAL FORM IN COMPLEX WITH METHYL-4II-S-ALPHA-CELLOBIOSYL-4II-THIO-BETA-CELLOBIOSIDE | Descriptor: | CALCIUM ION, ENDOGLUCANASE 5A, alpha-D-glucopyranose-(1-4)-4-thio-beta-D-glucopyranose-(1-4)-4-thio-beta-D-glucopyranose-(1-4)-methyl beta-D-glucopyranoside | Authors: | Fort, S, Varrot, A, Schulein, M, Cottaz, S, Driguez, H, Davies, G.J. | Deposit date: | 2000-07-26 | Release date: | 2001-07-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mixed-Linkage Cellooligosaccharides: A New Class of Glycoside Hydrolase Inhibitors Chembiochem, 2, 2001
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6ZZW
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![BU of 6zzw by Molmil](/molmil-images/mine/6zzw) | Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) and CAS No 912569-62-1 | Descriptor: | Lectin, SODIUM ION, [3-(2-methylimidazol-1-yl)phenyl]methanamine, ... | Authors: | Lal, K, Bermeo, R, Imberty, A, Varrot, A. | Deposit date: | 2020-08-05 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*. Chemistry, 27, 2021
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5A6X
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![BU of 5a6x by Molmil](/molmil-images/mine/5a6x) | Structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 in complex with alpha-methyl-fucoside | Descriptor: | CALCIUM ION, FUCOSE-BINDING LECTIN PA-IIL, methyl alpha-L-fucopyranoside | Authors: | Sommer, R, Wagner, S, Varrot, A, Khaledi, A, Haussler, S, Imberty, A, Titz, A. | Deposit date: | 2015-07-02 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery. Chem Sci, 7, 2016
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5A6Q
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![BU of 5a6q by Molmil](/molmil-images/mine/5a6q) | Native structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, FUCOSE-BINDING LECTIN PA-IIL, ... | Authors: | Sommer, R, Wagner, S, Varrot, A, Khaledi, A, Haussler, S, Imberty, A, Titz, A. | Deposit date: | 2015-06-30 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery. Chem Sci, 7, 2016
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5A6Z
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![BU of 5a6z by Molmil](/molmil-images/mine/5a6z) | Structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 in complex with lewis a | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, LECB, ... | Authors: | Sommer, R, Wagner, S, Varrot, A, Khaledi, A, Haussler, S, Imberty, A, Titz, A. | Deposit date: | 2015-07-02 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery. Chem Sci, 7, 2016
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