8Y2C
| Cryo-EM structure of human dopamine transporter in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter | Authors: | Zhao, Y, Li, Y. | Deposit date: | 2024-01-25 | Release date: | 2024-08-14 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Dopamine reuptake and inhibitory mechanisms in human dopamine transporter. Nature, 632, 2024
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8Y2E
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8Y2G
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8WFJ
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8Y2F
| Cryo-EM structure of human dopamine transporter in complex with GBR12909 | Descriptor: | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent dopamine transporter | Authors: | Zhao, Y, Li, Y. | Deposit date: | 2024-01-25 | Release date: | 2024-08-14 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Dopamine reuptake and inhibitory mechanisms in human dopamine transporter. Nature, 632, 2024
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8Y2D
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8WMM
| Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary) | Descriptor: | MAGNESIUM ION, NTS, PcrIIC1, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-10-04 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WMN
| Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (symmetric 20-nt complementary) | Descriptor: | DNA (62-MER), MAGNESIUM ION, PcrIIC1, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-10-04 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WR4
| Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (non-targeting complex) | Descriptor: | CbCas9 effector-1, DNA (62-MER), MAGNESIUM ION, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-10-13 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WMH
| Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate | Descriptor: | NTS, TS, deadCbCas9, ... | Authors: | Zhang, S, Lin, S, Liu, J.J.G. | Deposit date: | 2023-10-03 | Release date: | 2024-06-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity. Nature, 630, 2024
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8WTW
| Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue | Descriptor: | CHLORIDE ION, MrlA, SODIUM ION, ... | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTU
| Cryo-EM structure of noradrenaline transporter in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium-dependent noradrenaline transporter | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTX
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8WTY
| Cryo-EM structure of noradrenaline transporter in complex with ziprasidone | Descriptor: | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloranyl-1,3-dihydroindol-2-one, Sodium-dependent noradrenaline transporter | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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8WTV
| Cryo-EM structure of noradrenaline transporter in complex with noradrenaline | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Noradrenaline, ... | Authors: | Zhao, Y, Hu, T, Yu, Z. | Deposit date: | 2023-10-19 | Release date: | 2024-08-07 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Transport and inhibition mechanisms of the human noradrenaline transporter. Nature, 632, 2024
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9B3G
| Human Notch-1 EGFs 21-23 | Descriptor: | BARIUM ION, Neurogenic locus notch homolog protein 1 | Authors: | Johnson, S, Sheppard, D, Handford, P.A, Lea, S.M. | Deposit date: | 2024-03-19 | Release date: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation To Be Published
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9B3N
| Human Notch-1 EGFs 20-24 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Neurogenic locus notch homolog protein 1, ... | Authors: | Johnson, S, Suckling, R, Handford, P.A, Lea, S.M. | Deposit date: | 2024-03-19 | Release date: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation To Be Published
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7YJ3
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | Authors: | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | Deposit date: | 2022-07-19 | Release date: | 2023-07-19 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
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7YHW
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | Deposit date: | 2022-07-14 | Release date: | 2023-07-19 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
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7XEY
| EDS1-PAD4 complexed with pRib-ADP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Huang, S, Jia, A, Xiao, Y. | Deposit date: | 2022-03-31 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science, 377, 2022
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7XDD
| Cryo-EM structure of EDS1 and PAD4 | Descriptor: | Lipase-like PAD4, Protein EDS1 | Authors: | Huang, S.J, Jia, A.L, Sun, Y, Han, Z.F, Chai, J.J. | Deposit date: | 2022-03-26 | Release date: | 2022-07-13 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science, 377, 2022
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7XOZ
| Crystal structure of RPPT-TIR | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | Authors: | Song, W, Jia, A, Huang, S, Chai, J. | Deposit date: | 2022-05-02 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science, 377, 2022
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7XJP
| Cryo-EM structure of EDS1 and SAG101 with ATP-APDR | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ISOPROPYL ALCOHOL, ... | Authors: | Huang, S.J, Jia, A.L, Han, Z.F, Chai, J.J. | Deposit date: | 2022-04-18 | Release date: | 2022-07-20 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science, 377, 2022
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3B2R
| Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil | Descriptor: | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase | Authors: | Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. | Deposit date: | 2007-10-19 | Release date: | 2008-05-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol.Pharmacol., 73, 2008
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