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7OWN
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BU of 7own by Molmil
HsNMT1 in complex with both MyrCoA and peptide AKSFSKPR
Descriptor: ALA-LYS-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWU
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BU of 7owu by Molmil
HsNMT1 in complex with both CoA and Myr-ANCFSKPR peptide
Descriptor: ALA-ASN-CYS-PHE-SER-LYS-PRO-ARG, COENZYME A, GLYCEROL, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWO
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BU of 7owo by Molmil
HsNMT1 in complex with both MyrCoA and N-acetylated KSFSKPR peptide
Descriptor: COENZYME A, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWM
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BU of 7owm by Molmil
HsNMT1 in complex with both MyrCoA and HCPA substrate peptide GKQNSKLR
Descriptor: GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, Neuron-specific calcium-binding protein hippocalcin, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWP
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BU of 7owp by Molmil
HsNMT1 in complex with both MyrCoA and ACE-G-(L-ORN)SFSKPR
Descriptor: ACE-GLY-ORN-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
7OWR
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BU of 7owr by Molmil
HsNMT1 in complex with both MyrCoA and peptide GGKSFSKPR
Descriptor: GLY-GLY-LYS-SER-PHE-SER-LYS-PRO-ARG, GLYCEROL, Glycylpeptide N-tetradecanoyltransferase 1, ...
Authors:Dian, C, Giglione, C, Meinnel, T.
Deposit date:2021-06-18
Release date:2022-12-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural and Large-scale Analysis Unveil the Intertwined Paths Promoting NMT-catalyzed Lysine and Glycine Myristoylation.
J.Mol.Biol., 434, 2022
3LP2
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BU of 3lp2 by Molmil
HIV-1 reverse transcriptase with inhibitor
Descriptor: 3-[4-(diethylamino)phenoxy]-6-(ethoxycarbonyl)-5,8-dihydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-1-ium, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H, ...
Authors:Yan, Y, Munshi, S.K, Prasad, G.S, Su, H.P.
Deposit date:2010-02-04
Release date:2010-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
J.Virol., 84, 2010
3MVL
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BU of 3mvl by Molmil
P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K
Descriptor: 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14
Authors:Sack, J.S.
Deposit date:2010-05-04
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38 Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
J.Med.Chem., 53, 2010
3LZB
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BU of 3lzb by Molmil
EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
Descriptor: Epidermal growth factor receptor, N-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide
Authors:Swinger, K.K.
Deposit date:2010-03-01
Release date:2011-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg.Med.Chem.Lett., 20, 2010
3MVM
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BU of 3mvm by Molmil
P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V
Descriptor: 4-{[5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14
Authors:Sack, J.S.
Deposit date:2010-05-04
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38? Map Kinase Inhibitor for the Treatment of Inflammatory Diseases
J.Med.Chem., 53, 2010
1KM8
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BU of 1km8 by Molmil
The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)
Descriptor: PHOSPHATE ION, RIBONUCLEASE, OOCYTES
Authors:Chern, S.-S, Musayev, F.N, Amiraslanov, I.R, Liao, Y.-D, Liaw, Y.-C.
Deposit date:2001-12-14
Release date:2003-09-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)
To be Published
1KM9
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BU of 1km9 by Molmil
The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)
Descriptor: PHOSPHATE ION, RIBONUCLEASE, OOCYTES
Authors:Chern, S.-S, Musayev, F.N, Amiraslanov, I.R, Liao, Y.-D, Liaw, Y.-C.
Deposit date:2001-12-14
Release date:2003-09-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)
To be Published
1MNH
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BU of 1mnh by Molmil
INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Davies, G.J, Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
8UH1
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BU of 8uh1 by Molmil
Crystal structure of T. brucei EIF4E6 in complex with EIF4G5 peptide
Descriptor: Eukaryotic translation initiation factor 4E type 6, MIF4G domain-containing protein
Authors:Guimaraes, B.G, Penteado, R.F.
Deposit date:2023-10-06
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Structural analysis of the Trypanosoma brucei EIF4E6/EIF4G5 complex reveals details of the interaction between unusual eIF4F subunits.
Sci Rep, 14, 2024
1LWD
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BU of 1lwd by Molmil
CRYSTAL STRUCTURE OF NADP-DEPENDENT ISOCITRATE DEHYDROGENASE FROM PORCINE HEART MITOCHONDRIA
Descriptor: ISOCITRIC ACID, Isocitrate Dehydrogenase, MANGANESE (II) ION, ...
Authors:Ceccarelli, C, Bahnson, B.J.
Deposit date:2002-05-31
Release date:2002-11-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Porcine Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Complexed with Mn2+ and Isocitrate
J.Biol.Chem., 277, 2002
1MCY
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BU of 1mcy by Molmil
SPERM WHALE MYOGLOBIN (MUTANT WITH INITIATOR MET AND WITH HIS 64 REPLACED BY GLN, LEU 29 REPLACED BY PHE
Descriptor: CARBON MONOXIDE, MYOGLOBIN (CARBONMONOXY), PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, T, Phillips Jr, G.N.
Deposit date:1995-07-19
Release date:1995-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A double mutant of sperm whale myoglobin mimics the structure and function of elephant myoglobin.
J.Biol.Chem., 270, 1995
1MNJ
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BU of 1mnj by Molmil
INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Krzywda, S, Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-04-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
1MNK
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BU of 1mnk by Molmil
INTERACTIONS AMONG RESIDUES CD3, E7, E10 AND E11 IN MYOGLOBINS: ATTEMPTS TO SIMULATE THE O2 AND CO BINDING PROPERTIES OF APLYSIA MYOGLOBIN
Descriptor: MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Krzywda, S, Wilkinson, A.J.
Deposit date:1995-01-11
Release date:1995-04-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry, 34, 1995
5U4X
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BU of 5u4x by Molmil
Coactivator-associated arginine methyltransferase 1 with TP-064
Descriptor: Histone-arginine methyltransferase CARM1, N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:DONG, A, ZENG, H, Saikatendu, K.S, STONE, H, WALKER, J.R, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-12-06
Release date:2016-12-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Oncotarget, 9, 2018
5U2N
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BU of 5u2n by Molmil
Crystal structure of human NAMPT with A-1326133
Descriptor: N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION
Authors:Longenecker, K.L, Raich, D, Korepanova, A.V.
Deposit date:2016-11-30
Release date:2017-06-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
4V44
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BU of 4v44 by Molmil
E. COLI (lacZ) BETA-GALACTOSIDASE IN COMPLEX WITH 2-F-LACTOSE
Descriptor: 2-deoxy-2-fluoro-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, Beta-Galactosidase, MAGNESIUM ION, ...
Authors:Juers, D.H, McCarter, J.D, Withers, S.G, Matthews, B.W.
Deposit date:2001-09-13
Release date:2014-07-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4V41
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BU of 4v41 by Molmil
E. COLI (LAC Z) BETA-GALACTOSIDASE (NCS CONSTRAINED MONOMER-MONOCLINIC)
Descriptor: BETA-GALACTOSIDASE, MAGNESIUM ION
Authors:Juers, D.H, Jacobson, R.H, Wigley, D, Zhang, X.J, Huber, R.E, Tronrud, D.E, Matthews, B.W.
Deposit date:2000-06-07
Release date:2014-07-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for alpha-complementation.
Protein Sci., 9, 2000
3YPI
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BU of 3ypi by Molmil
ELECTROPHILIC CATALYSIS IN TRIOSEPHOSPHASE ISOMERASE: THE ROLE OF HISTIDINE-95
Descriptor: PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Lolis, E, Petsko, G.A.
Deposit date:1990-12-31
Release date:1993-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95.
Biochemistry, 30, 1991
4V45
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BU of 4v45 by Molmil
E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE
Descriptor: 2-deoxy-2-fluoro-beta-D-galactopyranose, Beta-Galactosidase, MAGNESIUM ION, ...
Authors:Juers, D.H, McCarter, J.D, Withers, S.G, Matthews, B.W.
Deposit date:2001-09-13
Release date:2014-07-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
4BEN
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BU of 4ben by Molmil
R39-imipenem Acyl-enzyme crystal structure
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, ...
Authors:Van Elder, D, Sauvage, E, Herman, R, Kerff, F, Rocaboy, M, Charlier, P.
Deposit date:2013-03-11
Release date:2013-03-20
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structures of R39-Imipenem Acyl-Enzyme.
To be Published

238582

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