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6NKW
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BU of 6nkw by Molmil
Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma-methylene dGTP
Descriptor: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
6NL0
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BU of 6nl0 by Molmil
Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CF2 analogue of dGTP
Descriptor: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Batra, V.K, Wilson, S.H.
Deposit date:2019-01-07
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59, 2020
4M9L
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BU of 4m9l by Molmil
DNA Polymerase Beta E295K Soaked with dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
4M9H
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BU of 4m9h by Molmil
DNA Polymerase Beta E295K Soaked with dTTP
Descriptor: CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
4M9N
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BU of 4m9n by Molmil
DNA Polymerase Beta E295K Soaked with dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.275 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
4M9J
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BU of 4m9j by Molmil
DNA Polymerase Beta E295K Soaked with dUMPNPP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA Downstream Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.038 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
4M9G
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BU of 4m9g by Molmil
DNA Polymerase Beta E295K Binary Complex
Descriptor: CHLORIDE ION, DNA Downstream Strand, DNA Primer Strand, ...
Authors:Eckenroth, B.E, Doublie, S.
Deposit date:2013-08-14
Release date:2013-10-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection.
J.Biol.Chem., 288, 2013
4NRV
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BU of 4nrv by Molmil
Crystal Structure of non-edited human NEIL1
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endonuclease 8-like 1
Authors:Prakash, A, Doublie, S.
Deposit date:2013-11-27
Release date:2014-01-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing.
Dna Repair, 14, 2014
4NRW
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BU of 4nrw by Molmil
MvNei1-G86D
Descriptor: 5'-D(*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3', 5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', formamidopyrimidine-DNA glycosylase
Authors:Prakash, A, Doublie, S.
Deposit date:2013-11-27
Release date:2014-01-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing.
Dna Repair, 14, 2014
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