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6RU0
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BU of 6ru0 by Molmil
Light-Regulation of Imidazole Glycerol Phosphate Synthase by Interference with its Allosteric Machinery through Photo-Sensitive Unnatural Amino Acids
Descriptor: Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH, PHOSPHATE ION
Authors:Kneuttinger, A, Rajendran, C, Sterner, R.
Deposit date:2019-05-27
Release date:2020-05-20
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.648 Å)
Cite:Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.
Cell Chem Biol, 26, 2019
4EVZ
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BU of 4evz by Molmil
Structure of HisF-LUCA
Descriptor: HYDROGENPHOSPHATE ION, HisF-LUCA
Authors:Reisinger, B, Sperl, J, Rajendran, C, Merkl, R, Sterner, R.
Deposit date:2012-04-26
Release date:2013-11-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.462 Å)
Cite:Evidence for the existence of elaborate enzyme complexes in the Paleoarchean era.
J.Am.Chem.Soc., 136, 2014
2GVQ
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BU of 2gvq by Molmil
Anthranilate phosphoribosyl-transferase (TRPD) from S. solfataricus in complex with anthranilate
Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase
Authors:Marino, M, Deuss, M, Sterner, R, Mayans, O.
Deposit date:2006-05-03
Release date:2006-05-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
3GBR
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BU of 3gbr by Molmil
Anthranilate phosphoribosyl-transferase (TRPD) double mutant D83G F149S from S. solfataricus
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Bruning, M, Schlee, S, Deuss, M, Ivens, A, Mayans, O, Sterner, R.
Deposit date:2009-02-20
Release date:2009-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release
Biochemistry, 48, 2009
4MM1
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BU of 4mm1 by Molmil
GGGPS from Methanothermobacter thermautotrophicus
Descriptor: Geranylgeranylglyceryl phosphate synthase, SN-GLYCEROL-1-PHOSPHATE, TRIETHYLENE GLYCOL
Authors:Rajendran, C, Peterhoff, D, Beer, B, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
Deposit date:2013-09-07
Release date:2014-06-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8004 Å)
Cite:A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
4NAE
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BU of 4nae by Molmil
PcrB from Geobacillus kaustophilus, with bound G1P
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Heptaprenylglyceryl phosphate synthase, SN-GLYCEROL-1-PHOSPHATE
Authors:Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
Deposit date:2013-10-22
Release date:2014-06-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
6RG0
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BU of 6rg0 by Molmil
Structure of pdxj
Descriptor: Pyridoxine 5'-phosphate synthase
Authors:Rohweder, B, Rajendran, C, Sterner, R.
Deposit date:2019-04-16
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.074 Å)
Cite:Library Selection with a Randomized Repertoire of ( beta alpha )8-Barrel Enzymes Results in Unexpected Induction of Gene Expression.
Biochemistry, 58, 2019
4NAF
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BU of 4naf by Molmil
PrcB from Geobacillus kaustophilus, apo structure
Descriptor: Heptaprenylglyceryl phosphate synthase
Authors:Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
Deposit date:2013-10-22
Release date:2014-06-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
4EWN
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BU of 4ewn by Molmil
Structure of HisF-D130V+D176V with bound rCdRP
Descriptor: 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate, Imidazole glycerol phosphate synthase subunit HisF
Authors:Reisinger, B, Bocola, M, Rajendran, C, List, F, Sterner, R.
Deposit date:2012-04-27
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:A sugar isomerization reaction established on various (beta-alpha)8-barrel scaffolds is based on substrate-assisted catalysis
Protein Eng.Des.Sel., 25, 2012
1ZYK
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BU of 1zyk by Molmil
Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, ...
Authors:Marino, M, Deuss, M, Sterner, R, Mayans, O.
Deposit date:2005-06-10
Release date:2006-05-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
1ZXY
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BU of 1zxy by Molmil
Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus in complex with PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
Authors:Marino, M, Deuss, M, Sterner, R, Mayans, O.
Deposit date:2005-06-09
Release date:2006-05-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
2C3Z
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BU of 2c3z by Molmil
Crystal structure of a truncated variant of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus
Descriptor: INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, SULFATE ION
Authors:Schneider, A, Knoechel, T, Darimont, B, Hennig, M, Dietrich, S, Kirschner, K, Sterner, R.
Deposit date:2005-10-13
Release date:2005-10-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Role of the N-Terminal Extension of the (Betaalpha)(8)-Barrel Enzyme Indole-3-Glycerol Phosphate Synthase for its Fold, Stability, and Catalytic Activity.
Biochemistry, 44, 2005
5NF1
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BU of 5nf1 by Molmil
crystal structure of variants
Descriptor: Geranylgeranylglyceryl phosphate synthase
Authors:Linde, M, Rajendran, C, Babinger, P, Sterner, R.
Deposit date:2017-03-13
Release date:2018-05-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:crystal structure of variants
To Be Published
1ROF
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BU of 1rof by Molmil
NMR STUDY OF 4FE-4S FERREDOXIN OF THERMATOGA MARITIMA
Descriptor: FERREDOXIN, IRON/SULFUR CLUSTER
Authors:Roesch, P, Sticht, H, Wildegger, G, Bentrop, D, Darimont, B, Sterner, R.
Deposit date:1995-11-24
Release date:1996-06-10
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin.
Eur.J.Biochem., 237, 1996
4JEJ
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BU of 4jej by Molmil
GGGPS from Flavobacterium johnsoniae
Descriptor: Geranylgeranylglyceryl phosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Peterhoff, D, Beer, B, Rajendran, C, Kumpula, E.P, Kapetaniou, E, Guldan, H, Wierenga, R.K, Sterner, R, Babinger, P.
Deposit date:2013-02-27
Release date:2014-06-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol., 92, 2014
4J5N
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BU of 4j5n by Molmil
Crystal Structure of a Deinococcus radiodurans PTE-like lactonase (drPLL) mutant Y28L/D71N/E101G/E179D/V235L/L270M
Descriptor: COBALT (II) ION, Phosphotriesterase, putative
Authors:Meier, M.M, Rajendran, C, Malisi, C, Fox, N.G, Xu, C, Schlee, S, Barondeau, D.P, Hocker, B, Sterner, R, Raushel, F.M.
Deposit date:2013-02-08
Release date:2013-07-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
J.Am.Chem.Soc., 135, 2013
1THF
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BU of 1thf by Molmil
CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROLPHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA
Descriptor: HISF PROTEIN, PHOSPHATE ION
Authors:Lang, D.A, Wilmanns, M.
Deposit date:1998-09-17
Release date:2000-07-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion.
Science, 289, 2000
1NSJ
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BU of 1nsj by Molmil
CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE FROM THERMOTOGA MARITIMA
Descriptor: PHOSPHATE ION, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
Authors:Hennig, M, Jansonius, J.N.J.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.
Biochemistry, 36, 1997
7AC8
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BU of 7ac8 by Molmil
Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Descriptor: GLUTAMINE, Imidazole glycerol phosphate synthase subunit HisF, Imidazole glycerol phosphate synthase subunit HisH, ...
Authors:Sung, S, Wilmanns, M.
Deposit date:2020-09-10
Release date:2021-05-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.
Nat Commun, 12, 2021
6HTE
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BU of 6hte by Molmil
Sulfolobus solfataricus Tryptophan Synthase B2a
Descriptor: DI(HYDROXYETHYL)ETHER, PYRIDOXAL-5'-PHOSPHATE, Tryptophan synthase beta chain 2
Authors:Fleming, J, Mayans, O, Bucher, R.
Deposit date:2018-10-04
Release date:2018-11-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.
J.Mol.Biol., 430, 2018
8BKD
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BU of 8bkd by Molmil
structure of RutB
Descriptor: N-(AMINOCARBONYL)-BETA-ALANINE, Ureidoacrylate amidohydrolase RutB
Authors:Rajendran, C.
Deposit date:2022-11-09
Release date:2023-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
8BLM
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BU of 8blm by Molmil
Structure of RutB
Descriptor: Ureidoacrylate amidohydrolase RutB
Authors:Rajendran, C.
Deposit date:2022-11-09
Release date:2023-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
8BLL
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BU of 8bll by Molmil
Structure of RutB
Descriptor: ACETATE ION, Ureidoacrylate amidohydrolase RutB
Authors:Rajendran, C.
Deposit date:2022-11-09
Release date:2023-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023
5EY5
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BU of 5ey5 by Molmil
LBCATS
Descriptor: LBCA-b, LBCATS-a, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Busch, F, Rajendran, C, Schlee, S, Heyn, K, Merkl, R, Sterner, R.
Deposit date:2015-11-24
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.972 Å)
Cite:LBCATS
To Be Published
8BLN
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BU of 8bln by Molmil
Structure of RutB
Descriptor: Ureidoacrylate amidohydrolase RutB
Authors:Rajendran, C.
Deposit date:2022-11-09
Release date:2023-09-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli .
Biochemistry, 62, 2023

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