7N0K
 
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3SPI
 | | Inward rectifier potassium channel Kir2.2 in complex with PIP2 | | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | | Deposit date: | 2011-07-01 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.307 Å) | | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
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3SYA
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | | Authors: | Whorton, M.R, MacKinnon, R. | | Deposit date: | 2011-07-16 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
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3SPH
 | | Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2 | | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | | Deposit date: | 2011-07-01 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.003 Å) | | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
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3SPC
 | | Inward rectifier potassium channel Kir2.2 in complex with dioctanoylglycerol pyrophosphate (DGPP) | | Descriptor: | (2R)-3-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate, Inward-rectifier K+ channel Kir2.2, POTASSIUM ION | | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | | Deposit date: | 2011-07-01 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.454 Å) | | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
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3SYC
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3SPG
 | | Inward rectifier potassium channel Kir2.2 R186A mutant in complex with PIP2 | | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | | Deposit date: | 2011-07-01 | | Release date: | 2011-08-24 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.613 Å) | | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2.
Nature, 477, 2011
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3SYP
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3SYO
 | | Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium | | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION | | Authors: | Whorton, M.R, MacKinnon, R. | | Deposit date: | 2011-07-18 | | Release date: | 2011-10-12 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.54 Å) | | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Cell(Cambridge,Mass.), 147, 2011
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5A6E
 | | Cryo-EM structure of the Slo2.2 Na-activated K channel | | Descriptor: | GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, ... | | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | | Deposit date: | 2015-06-25 | | Release date: | 2015-10-14 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
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5A6G
 | | Cryo-EM structure of the Slo2.2 Na-activated K channel | | Descriptor: | PORE DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, S1-S4 DOMAIN OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 | | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | | Deposit date: | 2015-06-25 | | Release date: | 2015-10-14 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (5.2 Å) | | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
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4FG6
 | | Structure of EcCLC E148A mutant in Glutamate | | Descriptor: | Fab fragment (Heavy chain), Fab fragment (Light chain), H(+)/Cl(-) exchange transporter ClcA | | Authors: | Feng, L, MacKinnon, R. | | Deposit date: | 2012-06-04 | | Release date: | 2012-07-04 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.019 Å) | | Cite: | Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4HPF
 | | Structure of the human SLO3 gating ring | | Descriptor: | Potassium channel subfamily U member 1 | | Authors: | Leonetti, M.D, Yuan, P, MacKinnon, R. | | Deposit date: | 2012-10-23 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2NLJ
 | | Potassium Channel KcsA(M96V)-Fab complex in KCl | | Descriptor: | DIACYL GLYCEROL, POTASSIUM ION, Voltage-gated potassium channel, ... | | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | | Deposit date: | 2006-10-20 | | Release date: | 2007-05-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
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3LNM
 | | F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Tao, X, Lee, A, Limapichat, W, Dougherty, D.A, MacKinnon, R. | | Deposit date: | 2010-02-02 | | Release date: | 2010-04-14 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A gating charge transfer center in voltage sensors.
Science, 328, 2010
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3MT5
 | | Crystal Structure of the Human BK Gating Apparatus | | Descriptor: | CALCIUM ION, Potassium large conductance calcium-activated channel, subfamily M, ... | | Authors: | Yuan, P, MacKinnon, R. | | Deposit date: | 2010-04-30 | | Release date: | 2010-06-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
Science, 329, 2010
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1EXB
 | | STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS | | Descriptor: | KV BETA2 PROTEIN, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM CHANNEL KV1.1 | | Authors: | Gulbis, J.M, Zhou, M, Mann, S, MacKinnon, R. | | Deposit date: | 2000-05-02 | | Release date: | 2000-07-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
Science, 289, 2000
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8EP1
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8EOW
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8EP0
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5A6F
 | | Cryo-EM structure of the Slo2.2 Na-activated K channel | | Descriptor: | GATING RING OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1, RCK2 ELABORATION OF POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 | | Authors: | Hite, R.K, Yuan, P, Li, Z, Hsuing, Y, Walz, T, MacKinnon, R. | | Deposit date: | 2015-06-25 | | Release date: | 2015-10-14 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-Electron Microscopy Structure of the Slo2.2 Na1-Activated K1 Channel
Nature, 527, 2015
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8SIK
 | | KCNQ1 with voltage sensor in the up conformation | | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mandala, V.S, MacKinnon, R. | | Deposit date: | 2023-04-16 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SIM
 | | KCNQ1 with voltage sensor in the intermediate conformation | | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mandala, V.S, MacKinnon, R. | | Deposit date: | 2023-04-16 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SIN
 | | KCNQ1 with voltage sensor in the down conformation | | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mandala, V.S, MacKinnon, R. | | Deposit date: | 2023-04-16 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
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1AGT
 | | SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY | | Descriptor: | AGITOXIN 2 | | Authors: | Krezel, A.M, Kasibhatla, C, Hidalgo, P, Mackinnon, R, Wagner, G. | | Deposit date: | 1995-04-14 | | Release date: | 1995-07-10 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry.
Protein Sci., 4, 1995
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