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CryoEM structure of Western equine encephalitis virus VLP in complex with the chimeric Du-D1-Mo-D2 MXRA8 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, DuD1MoD2 chimeric MXRA8, E1 envelope glycoprotein, ...
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2023-05-04
Release date:	2023-12-20
Method:	ELECTRON MICROSCOPY (3.89 Å)
Cite:	Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8. Cell, 186, 2023

6XO4

CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP
Descriptor:	Togavirin
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2020-07-06
Release date:	2020-12-23
Last modified:	2021-01-13
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection. Cell, 183, 2020

6XOB

CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143.
Descriptor:	EEEV-143 Fab heavy chain, EEEV-143 Fab light chain, Togavirin
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2020-07-06
Release date:	2020-12-23
Last modified:	2021-01-13
Method:	ELECTRON MICROSCOPY (8.5 Å)
Cite:	Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection. Cell, 183, 2020

8DAQ

CryoEM structure of Western equine encephalitis virus VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-06-13
Release date:	2023-12-20
Method:	ELECTRON MICROSCOPY (4.35 Å)
Cite:	Alternate repeat domain usage in an alphavirus entry receptor enables host species expansion To Be Published

8DAN

CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein, ...
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-06-13
Release date:	2023-12-20
Method:	ELECTRON MICROSCOPY (4.74 Å)
Cite:	Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion To Be Published

5AWN

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab
Descriptor:	Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab
Authors:	Lee, J.H, Wilson, I.A, Ward, A.B.
Deposit date:	2015-07-06
Release date:	2015-11-11
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (1.887 Å)
Cite:	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

5CCK

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
Descriptor:	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
Authors:	Lee, J.H, Ward, A.B, Wilson, I.A.
Deposit date:	2015-07-02
Release date:	2015-10-07
Last modified:	2019-12-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

6CRJ

Mouse norovirus model using the crystal structure of MNV P domain and the Norwalkvirus shell domain
Descriptor:	Norwalk virus, MNV-1 capsid protein chimera
Authors:	Smith, T.J.
Deposit date:	2018-03-19
Release date:	2018-04-04
Last modified:	2024-03-13
Method:	ELECTRON MICROSCOPY (8 Å)
Cite:	Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

6C6Q

Crystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf Receptor
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, CMRF35-like molecule 1, ...
Authors:	Nelson, C.A, Fremont, D.H.
Deposit date:	2018-01-19
Release date:	2018-09-12
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

6C74

Crystal Structure of Murine CD300lf in complex with phosphocholine
Descriptor:	CALCIUM ION, CMRF35-like molecule-1, PHOSPHOCHOLINE
Authors:	Nelson, C.A, Fremont, D.H.
Deposit date:	2018-01-19
Release date:	2018-09-12
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.358 Å)
Cite:	Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

6W2U

Mayaro Virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit
Descriptor:	Spike glycoprotein E1, Spike glycoprotein E2
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-03-08
Release date:	2020-10-07
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4.8 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

6VYV

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-02-27
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (6.33 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

6W09

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, E3, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-02-29
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (5.3 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

6W1C

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-03-04
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (5.3 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

8EWF

CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Chimeric MXRA8 receptor: D1 from Duck MXRA8 and D2 from Mouse MXRA8, E1 envelope protein, ...
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-10-22
Release date:	2023-10-25
Method:	ELECTRON MICROSCOPY (3.92 Å)
Cite:	Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion To Be Published

6NK5

Electron Cryo-Microscopy Of Chikungunya VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 glycoprotein, ...
Authors:	Basore, K, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2019-01-04
Release date:	2019-05-22
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.16 Å)
Cite:	Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor. Cell, 177, 2019

6O3G

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
Descriptor:	GLYCEROL, MEPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.645 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3K

Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3
Descriptor:	GLYCEROL, PGZL1.H4K3 heavy chain, PGZL1.H4K3 light chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.451 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3U

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA
Descriptor:	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, GLYCEROL, PGZL1.H4K3 heavy chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-27
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.105 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3D

Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1.
Descriptor:	GLYCEROL, PGZL1 FAB HEAVY CHAIN, PGZL1 FAB LIGHT CHAIN, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.402 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3J

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41) and phosphatidic acid (06:0 PA)
Descriptor:	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, (4S)-2-METHYL-2,4-PENTANEDIOL, MPER peptide, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.416 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3L

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
Descriptor:	GLYCEROL, MPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O41

Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ)
Descriptor:	GLYCEROL, Immunoglobulin G-binding protein G (DOMAIN III), germline PGZL1_gVmDmJ heavy chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-27
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.465 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

7SFW

CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2021-10-04
Release date:	2022-03-16
Last modified:	2022-07-06
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. J.Exp.Med., 219, 2022

7SFU

CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2021-10-04
Release date:	2022-03-16
Last modified:	2022-07-06
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. J.Exp.Med., 219, 2022

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