2L6Y
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![BU of 2l6y by Molmil](/molmil-images/mine/2l6y) | haddock model of GATA1NF:Lmo2LIM2-Ldb1LID | Descriptor: | Erythroid transcription factor, LIM domain only 2, linker, ... | Authors: | Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M. | Deposit date: | 2010-12-01 | Release date: | 2011-08-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 Proc.Natl.Acad.Sci.USA, 108, 2011
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2L6Z
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![BU of 2l6z by Molmil](/molmil-images/mine/2l6z) | haddock model of GATA1NF:Lmo2LIM2-Ldb1LID with FOG | Descriptor: | Erythroid transcription factor, LIM domain only 2, linker, ... | Authors: | Wilkinson-White, L, Gamsjaeger, R, Dastmalchi, S, Wienert, B, Stokes, P.H, Crossley, M, Mackay, J.P, Matthews, J.M. | Deposit date: | 2010-12-01 | Release date: | 2011-08-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 Proc.Natl.Acad.Sci.USA, 108, 2011
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6CVD
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![BU of 6cvd by Molmil](/molmil-images/mine/6cvd) | High resolution crystal structure of FtsY-NG domain of E. coli bound to fragment 1 | Descriptor: | AMMONIUM ION, SODIUM ION, Signal recognition particle receptor FtsY, ... | Authors: | Faoro, C, Ataide, S.F, Kwan, A, Wilkinson-White, L. | Deposit date: | 2018-03-27 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics. PLoS ONE, 13, 2018
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2LXD
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![BU of 2lxd by Molmil](/molmil-images/mine/2lxd) | Backbone 1H, 13C, and 15N Chemical Shift Assignments for LMO2(LIM2)-Ldb1(LID) | Descriptor: | Rhombotin-2,LIM domain-binding protein 1, ZINC ION | Authors: | Dastmalchi, S, Wilkinson-White, L, Kwan, A.H, Gamsjaeger, R, Mackay, J.P, Matthews, J.M. | Deposit date: | 2012-08-20 | Release date: | 2012-09-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex. Protein Sci., 21, 2012
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3VD6
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![BU of 3vd6 by Molmil](/molmil-images/mine/3vd6) | Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P21 Crystal Form | Descriptor: | ACETATE ION, DNA (5'-D(*AP*AP*GP*AP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*TP*C)-3'), ... | Authors: | Jacques, D.A, Ripin, N, Wilkinson-White, L.E, Guss, J.M, Matthews, J.M. | Deposit date: | 2012-01-04 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA. Protein Sci., 24, 2015
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3VEK
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![BU of 3vek by Molmil](/molmil-images/mine/3vek) | Both Zn Fingers of GATA1 Bound to Palindromic DNA Recognition Site, P1 Crystal Form | Descriptor: | DNA (5'-D(*AP*AP*GP*AP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*TP*C)-3'), Erythroid transcription factor, ... | Authors: | Jacques, D.A, Ripin, N, Wilkinson-White, L.E, Guss, J.M, Matthews, J.M. | Deposit date: | 2012-01-09 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA. Protein Sci., 24, 2015
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6BGG
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![BU of 6bgg by Molmil](/molmil-images/mine/6bgg) | Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide | Descriptor: | Bromodomain-containing protein 3, CHD4 | Authors: | Wai, D.C.C, Szyszka, T.N, Campbell, A.E, Kwong, C, Wilkinson-White, L, Silva, A.P.G, Low, J.K.K, Kwan, A.H, Gamsjaeger, R, Lu, B, Vakoc, C.R, Blobel, G.A, Mackay, J.P. | Deposit date: | 2017-10-28 | Release date: | 2018-03-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. J. Biol. Chem., 293, 2018
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6CS8
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![BU of 6cs8 by Molmil](/molmil-images/mine/6cs8) | High resolution crystal structure of FtsY-NG domain of E. coli | Descriptor: | 1H-indole-6-carbonitrile, SODIUM ION, Signal recognition particle receptor FtsY | Authors: | Faoro, C, Ataide, S.F. | Deposit date: | 2018-03-19 | Release date: | 2018-08-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics. PLoS ONE, 13, 2018
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6CQP
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![BU of 6cqp by Molmil](/molmil-images/mine/6cqp) | High resolution crystal structure of FtsY-NG domain of E. coli | Descriptor: | GLYCEROL, SODIUM ION, Signal recognition particle receptor FtsY | Authors: | Faoro, C, Ataide, S.F. | Deposit date: | 2018-03-15 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.446 Å) | Cite: | Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics. PLoS ONE, 13, 2018
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6DLX
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![BU of 6dlx by Molmil](/molmil-images/mine/6dlx) | FtsY-NG domain bound to fragment 3. | Descriptor: | 4-bromo-2,5-dimethoxyaniline, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Ataide, F.S, Faoro, C. | Deposit date: | 2018-06-04 | Release date: | 2018-08-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.848 Å) | Cite: | Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics. PLoS ONE, 13, 2018
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6U6K
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![BU of 6u6k by Molmil](/molmil-images/mine/6u6k) | BRD4-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-30 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U4A
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![BU of 6u4a by Molmil](/molmil-images/mine/6u4a) | BRD3-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 3, GLYCEROL, SULFATE ION, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-24 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U71
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![BU of 6u71 by Molmil](/molmil-images/mine/6u71) | BRD2-BD2 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 2, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U8G
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![BU of 6u8g by Molmil](/molmil-images/mine/6u8g) | BRD4-BD2 in complex with the cyclic peptide 3.1_2_AcK7toA | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_2_AcK7toA | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P, Mouradian, K.S. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U72
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![BU of 6u72 by Molmil](/molmil-images/mine/6u72) | BRD4-BD1 in complex with the cyclic peptide 3.1_2_AcK5toA | Descriptor: | 3.1_2_AcK5toA, AMINO GROUP, Bromodomain-containing protein 4 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P, Mouradian, K.S. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ULS
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![BU of 6uls by Molmil](/molmil-images/mine/6uls) | BRD4-BD1 in complex with the a diacetylated-E2F1 peptide | Descriptor: | Bromodomain-containing protein 4, Diacetylated E2F1 Peptide (K117ac and K120ac) | Authors: | Patel, K, Low, J.K.K, Mackay, J.P. | Deposit date: | 2019-10-08 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | BET-Family Bromodomains Can Recognize Diacetylated Sequences from Transcription Factors Using a Conserved Mechanism. Biochemistry, 60, 2021
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6U61
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![BU of 6u61 by Molmil](/molmil-images/mine/6u61) | BRD2-BD1 in complex with the cyclic peptide 3.1_3 | Descriptor: | Bromodomain-containing protein 2, ZINC ION, cyclic peptide 3.1_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-28 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U6L
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![BU of 6u6l by Molmil](/molmil-images/mine/6u6l) | BRD4-BD2 in complex with the cyclic peptide 3.1_2 | Descriptor: | AMINO GROUP, Bromodomain-containing protein 4, Cyclic peptide 3.1_2, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-30 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U8H
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![BU of 6u8h by Molmil](/molmil-images/mine/6u8h) | BRD2-BD1 in complex with the cyclic peptide 3.2_2 | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, AMINO GROUP, Bromodomain-containing protein 2, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U8M
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![BU of 6u8m by Molmil](/molmil-images/mine/6u8m) | BRD4-BD1 in complex with the cyclic peptide 3.2_1 | Descriptor: | AMINO GROUP, Bromodomain-containing protein 4, cyclic peptide 3.2_1 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ULQ
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![BU of 6ulq by Molmil](/molmil-images/mine/6ulq) | BRD2-BD1 in complex with the cyclic peptide 4.2_3 | Descriptor: | Bromodomain-containing protein 2, Cyclic peptide 4.2_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-10-08 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ULP
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![BU of 6ulp by Molmil](/molmil-images/mine/6ulp) | BRD3-BD2 in complex with the cyclic peptide 3.2_3 | Descriptor: | Bromodomain-containing protein 3, Cyclic peptide 3.2_3 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-10-08 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U74
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![BU of 6u74 by Molmil](/molmil-images/mine/6u74) | BRD4-BD1 in complex with the cyclic peptide 3.1_2 | Descriptor: | Bromodomain-containing protein 4, cyclic peptide 3.1_2 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-08-31 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U8I
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![BU of 6u8i by Molmil](/molmil-images/mine/6u8i) | BRD4-BD2 in complex with the cyclic peptide 3.2_2 | Descriptor: | AMINO GROUP, Bromodomain-containing protein 4, cyclic peptide 3.2_2 | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-09-05 | Release date: | 2020-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ULV
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![BU of 6ulv by Molmil](/molmil-images/mine/6ulv) | BRD4-BD1 in complex with the cyclic peptide 4.2_1 | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bromodomain-containing protein 4, Cyclic peptide 4.2_3, ... | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | Deposit date: | 2019-10-08 | Release date: | 2020-12-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117, 2020
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