6U8H
BRD2-BD1 in complex with the cyclic peptide 3.2_2
Summary for 6U8H
| Entry DOI | 10.2210/pdb6u8h/pdb |
| Descriptor | Bromodomain-containing protein 2, cyclic peptide 3.2_2, IODIDE ION, ... (7 entities in total) |
| Functional Keywords | bet, bromodomain, macrocyclic peptide, brd2, inhibitor, rapid, transcription-inhibitor complex, transcription, transcription/inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 19150.84 |
| Authors | Patel, K.,Walshe, J.L.,Walport, L.J.,Mackay, J.P. (deposition date: 2019-09-05, release date: 2020-08-19, Last modification date: 2023-11-15) |
| Primary citation | Patel, K.,Walport, L.J.,Walshe, J.L.,Solomon, P.D.,Low, J.K.K.,Tran, D.H.,Mouradian, K.S.,Silva, A.P.G.,Wilkinson-White, L.,Norman, A.,Franck, C.,Matthews, J.M.,Guss, J.M.,Payne, R.J.,Passioura, T.,Suga, H.,Mackay, J.P. Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc.Natl.Acad.Sci.USA, 117:26728-26738, 2020 Cited by PubMed: 33046654DOI: 10.1073/pnas.2003086117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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