7E0E
 
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2RT4
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6KMC
 | | Crystal structure of a Streptococcal protein G B1 mutant | | Descriptor: | ACETIC ACID, Immunoglobulin G-binding protein G B1 | | Authors: | Watanabe, H, Honda, S. | | Deposit date: | 2019-07-31 | | Release date: | 2019-10-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Histidine-Mediated Intramolecular Electrostatic Repulsion for Controlling pH-Dependent Protein-Protein Interaction.
Acs Chem.Biol., 14, 2019
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2D7T
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3WKN
 | | Crystal structure of the artificial protein AFFinger p17 (AF.p17) complexed with Fc fragment of human IgG | | Descriptor: | AFFinger p17, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Watanabe, H, Honda, S. | | Deposit date: | 2013-10-29 | | Release date: | 2014-10-29 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Adaptive Assembly: Maximizing the Potential of a Given Functional Peptide with a Tailor-Made Protein Scaffold.
Chem.Biol., 22, 2015
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2ZW0
 | | Crystal structure of a Streptococcal protein G B1 mutant | | Descriptor: | Protein LG, SULFATE ION | | Authors: | Watanabe, H, Matsumaru, H, Odahara, T, Suto, K, Honda, S. | | Deposit date: | 2008-11-26 | | Release date: | 2009-03-03 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Optimizing pH response of affinity between protein G and IgG Fc: how electrostatic modulations affect protein-protein interactions.
J.Biol.Chem., 284, 2009
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2ZW1
 | | Crystal structure of a Streptococcal protein G B1 mutant | | Descriptor: | Protein LG | | Authors: | Watanabe, H, Matsumaru, H, Odahara, T, Suto, K, Honda, S. | | Deposit date: | 2008-11-26 | | Release date: | 2009-03-03 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Optimizing pH response of affinity between protein G and IgG Fc: how electrostatic modulations affect protein-protein interactions.
J.Biol.Chem., 284, 2009
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1IZC
 | | Crystal Structure Analysis of Macrophomate synthase | | Descriptor: | MAGNESIUM ION, PYRUVIC ACID, macrophomate synthase intermolecular Diels-Alderase | | Authors: | Ose, T, Watanabe, K, Mie, T, Honma, M, Watanabe, H, Yao, M, Oikawa, H, Tanaka, I. | | Deposit date: | 2002-10-01 | | Release date: | 2003-04-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase.
Nature, 422, 2003
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1BQ5
 | | NITRITE REDUCTASE FROM ALCALIGENES XYLOSOXIDANS GIFU 1051 | | Descriptor: | COPPER (II) ION, NITRITE REDUCTASE | | Authors: | Inoue, T, Gotowda, M, Deligeer, Suzuki, S, Kataoka, K, Yamaguchi, K, Watanabe, H, Goho, M, Yasushi, K.A.I. | | Deposit date: | 1998-08-21 | | Release date: | 1999-08-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Type 1 Cu structure of blue nitrite reductase from Alcaligenes xylosoxidans GIFU 1051 at 2.05 A resolution: comparison of blue and green nitrite reductases.
J.Biochem.(Tokyo), 124, 1998
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1KSD
 | | The structure of Endoglucanase from termite, Nasutitermes takasagoensis, at pH 6.5. | | Descriptor: | CALCIUM ION, Endo-b-1,4-glucanase | | Authors: | Khademi, S, Guarino, L.A, Watanabe, H, Tokuda, G, Meyer, E.F. | | Deposit date: | 2002-01-12 | | Release date: | 2003-01-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of an endoglucanase from termite, Nasutitermes takasagoensis.
Acta Crystallogr.,Sect.D, 58, 2002
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1KSC
 | | The structure of Endoglucanase from termite, Nasutitermes takasagoensis, at pH 5.6. | | Descriptor: | CALCIUM ION, Endo-b-1,4-glucanase | | Authors: | Khademi, S, Guarino, L.A, Watanabe, H, Tokuda, G, Meyer, E.F. | | Deposit date: | 2002-01-11 | | Release date: | 2003-01-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of an endoglucanase from termite, Nasutitermes takasagoensis.
Acta Crystallogr.,Sect.D, 58, 2002
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1KS8
 | | The structure of Endoglucanase from termite, Nasutitermes takasagoensis, at pH 2.5. | | Descriptor: | Endo-b-1,4-glucanase, SULFATE ION | | Authors: | Khademi, S, Guarino, L.A, Watanabe, H, Tokuda, G, Meyer, E.F. | | Deposit date: | 2002-01-11 | | Release date: | 2003-01-21 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure of an endoglucanase from termite, Nasutitermes takasagoensis.
Acta Crystallogr.,Sect.D, 58, 2002
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3WIR
 | | Crystal structure of kojibiose phosphorylase complexed with glucose | | Descriptor: | GLYCEROL, Kojibiose phosphorylase, PHOSPHATE ION, ... | | Authors: | Okada, S, Yamamoto, T, Watanabe, H, Nishimoto, T, Chaen, H, Fukuda, S, Wakagi, T, Fushinobu, S. | | Deposit date: | 2013-09-24 | | Release date: | 2014-02-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural and mutational analysis of substrate recognition in kojibiose phosphorylase
Febs J., 281, 2014
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3WIQ
 | | Crystal structure of kojibiose phosphorylase complexed with kojibiose | | Descriptor: | Kojibiose phosphorylase, SULFATE ION, alpha-D-glucopyranose-(1-2)-beta-D-glucopyranose | | Authors: | Okada, S, Yamamoto, T, Watanabe, H, Nishimoto, T, Chaen, H, Fukuda, S, Wakagi, T, Fushinobu, S. | | Deposit date: | 2013-09-24 | | Release date: | 2014-02-05 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and mutational analysis of substrate recognition in kojibiose phosphorylase
Febs J., 281, 2014
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3APX
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and chlorpromazine complex | | Descriptor: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, ACETIC ACID, Alpha-1-acid glycoprotein 2 | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
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3APW
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and disopyramide complex | | Descriptor: | Alpha-1-acid glycoprotein 2, Disopyramide | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
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3APU
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein | | Descriptor: | Alpha-1-acid glycoprotein 2, TETRAETHYLENE GLYCOL | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
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3APV
 | | Crystal structure of the A variant of human alpha1-acid glycoprotein and amitriptyline complex | | Descriptor: | ACETIC ACID, Alpha-1-acid glycoprotein 2, Amitriptyline | | Authors: | Nishi, K, Ono, T, Nakamura, T, Fukunaga, N, Izumi, M, Watanabe, H, Suenaga, A, Maruyama, T, Yamagata, Y, Curry, S, Otagiri, M. | | Deposit date: | 2010-10-21 | | Release date: | 2011-02-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.
J. Biol. Chem., 286, 2011
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3TDC
 | | Crystal Structure of Human Acetyl-CoA carboxylase 2 | | Descriptor: | 1-[3-({4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea, Acetyl-CoA carboxylase 2 variant | | Authors: | Dougan, D.R, Mol, C.D. | | Deposit date: | 2011-08-10 | | Release date: | 2011-10-12 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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4ENY
 | | Crystal Structure of Pim-1 kinase in complex with (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidin-4-one | | Descriptor: | (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazolidin-4-one, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Parker, L.J, Handa, N, Yokoyama, S. | | Deposit date: | 2012-04-13 | | Release date: | 2012-08-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Acta Crystallogr.,Sect.F, 68, 2012
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4ENX
 | | Crystal Structure of Pim-1 Kinase in complex with inhibitor (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-nitrobenzylidene)thiazolidin-4-one | | Descriptor: | (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one, PHOSPHATE ION, Serine/threonine-protein kinase pim-1 | | Authors: | Parker, L.J, Handa, N, Yokoyama, S. | | Deposit date: | 2012-04-13 | | Release date: | 2012-08-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor
Acta Crystallogr.,Sect.F, 68, 2012
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5VUA
 | | Pim1 Kinase in complex with a benzofuranone inhibitor | | Descriptor: | (2Z)-6-methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[2,3-c]pyridin-3-ylmethylidene)-1-benzofuran-3-one, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Parker, L.J. | | Deposit date: | 2017-05-18 | | Release date: | 2017-12-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach
J Chem Inf Model, 57, 2017
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5VUB
 | | Pim1 Kinase in complex with a benzofuranone inhibitor | | Descriptor: | (2Z)-6-methoxy-7-(piperazin-1-ylmethyl)-2-(1H-pyrrolo[3,2-b]pyridin-3-ylmethylidene)-1-benzofuran-3-one, GLYCEROL, Serine/threonine-protein kinase pim-1 | | Authors: | Parker, L.J. | | Deposit date: | 2017-05-18 | | Release date: | 2017-12-13 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach
J Chem Inf Model, 57, 2017
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5VUC
 | | Pim1 Kinase in complex with a benzofuranone inhibitor | | Descriptor: | (2Z)-2-(1H-indol-3-ylmethylidene)-6-methoxy-7-(piperazin-1-ylmethyl)-1-benzofuran-3-one, GLYCEROL, Serine/threonine-protein kinase pim-1 | | Authors: | Parker, L.J. | | Deposit date: | 2017-05-18 | | Release date: | 2017-12-13 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Theoretical Analysis of Activity Cliffs among Benzofuranone-Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach
J Chem Inf Model, 57, 2017
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7PAZ
 | | REDUCED MUTANT P80I PSEUDOAZURIN FROM A. FAECALIS | | Descriptor: | COPPER (II) ION, PSEUDOAZURIN | | Authors: | Adman, E.T, Libeu, C.A.P. | | Deposit date: | 1997-02-21 | | Release date: | 1997-08-20 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Site-directed mutants of pseudoazurin: explanation of increased redox potentials from X-ray structures and from calculation of redox potential differences.
Biochemistry, 36, 1997
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