2RAB
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![BU of 2rab by Molmil](/molmil-images/mine/2rab) | Structure of glutathione amide reductase from Chromatium gracile in complex with NAD | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, NICKEL (II) ION, ... | Authors: | Van Petegem, F, De Vos, D, Savvides, S, Vergauwen, B, Van Beeumen, J. | Deposit date: | 2007-09-14 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase. J.Mol.Biol., 374, 2007
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2R9Z
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![BU of 2r9z by Molmil](/molmil-images/mine/2r9z) | Glutathione amide reductase from Chromatium gracile | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Glutathione amide reductase, ... | Authors: | Van Petegem, F, Vergauwen, B, Savvides, S, De Vos, D, Van Beeumen, J. | Deposit date: | 2007-09-14 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase. J.Mol.Biol., 374, 2007
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2BE7
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![BU of 2be7 by Molmil](/molmil-images/mine/2be7) | Crystal structure of the unliganded (T-state) aspartate transcarbamoylase of the psychrophilic bacterium Moritella profunda | Descriptor: | Aspartate Carbamoyltransferase Catalytic Chain, Aspartate Carbamoyltransferase Regulatory Chain, SULFATE ION, ... | Authors: | De Vos, D, Savvides, S.N, Van Beeumen, J. | Deposit date: | 2005-10-23 | Release date: | 2006-10-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural investigation of cold activity and regulation of aspartate carbamoyltransferase from the extreme psychrophilic bacterium Moritella profunda. J.Mol.Biol., 365, 2007
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2BE9
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![BU of 2be9 by Molmil](/molmil-images/mine/2be9) | Crystal structure of the CTP-liganded (T-State) aspartate transcarbamoylase from the extremely thermophilic archaeon Sulfolobus acidocaldarius | Descriptor: | Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | De Vos, D, Savvides, S.N, Van Beeumen, J.J. | Deposit date: | 2005-10-23 | Release date: | 2006-10-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP. Biochem.Biophys.Res.Commun., 372, 2008
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1XWQ
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![BU of 1xwq by Molmil](/molmil-images/mine/1xwq) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J.J, Feller, G. | Deposit date: | 2004-11-02 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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2A8Z
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![BU of 2a8z by Molmil](/molmil-images/mine/2a8z) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | endo-1,4-beta-xylanase | Authors: | Collins, T, De Vos, D, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J, Feller, G. | Deposit date: | 2005-07-10 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase. J.Mol.Biol., 354, 2005
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1XWT
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![BU of 1xwt by Molmil](/molmil-images/mine/1xwt) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J.J, Feller, G. | Deposit date: | 2004-11-02 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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1XW2
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![BU of 1xw2 by Molmil](/molmil-images/mine/1xw2) | Structure Of A Cold-Adapted Family 8 Xylanase | Descriptor: | Endo-1,4-beta-Xylanase | Authors: | Collins, T, De Vos, D, Hoyoux, A, Savvides, S.N, Gerday, C, Van Beeumen, J, Feller, G. | Deposit date: | 2004-10-29 | Release date: | 2005-10-11 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Study of the active site residues of a glycoside hydrolase family 8 xylanase J.Mol.Biol., 354, 2005
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2B4F
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![BU of 2b4f by Molmil](/molmil-images/mine/2b4f) | Structure Of A Cold-Adapted Family 8 Xylanase in complex with substrate | Descriptor: | beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, endo-1,4-beta-xylanase | Authors: | De Vos, D, Collins, T, Savvides, S.N, Feller, G, Van Beeumen, J.J. | Deposit date: | 2005-09-23 | Release date: | 2006-09-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Oligosaccharide binding in family 8 glycosidases: crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product. Biochemistry, 45, 2006
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1PG5
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![BU of 1pg5 by Molmil](/molmil-images/mine/1pg5) | CRYSTAL STRUCTURE OF THE UNLIGATED (T-STATE) ASPARTATE TRANSCARBAMOYLASE FROM THE EXTREMELY THERMOPHILIC ARCHAEON SULFOLOBUS ACIDOCALDARIUS | Descriptor: | Aspartate carbamoyltransferase, Aspartate carbamoyltransferase regulatory chain, ZINC ION | Authors: | De Vos, D, Van Petegem, F, Remaut, H, Legrain, C, Glansdorff, N, Van Beeumen, J.J. | Deposit date: | 2003-05-27 | Release date: | 2004-06-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of T State Aspartate Carbamoyltransferase of the Hyperthermophilic Archaeon Sulfolobus acidocaldarius. J.Mol.Biol., 339, 2004
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6S4A
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![BU of 6s4a by Molmil](/molmil-images/mine/6s4a) | Structure of human MTHFD2 in complex with TH9028 | Descriptor: | (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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6S4F
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![BU of 6s4f by Molmil](/molmil-images/mine/6s4f) | Structure of human MTHFD2 in complex with TH9619 | Descriptor: | (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, ADENOSINE-5'-DIPHOSPHATE, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | Authors: | Scaletti, E.R, Gustafsson, R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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6S4E
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![BU of 6s4e by Molmil](/molmil-images/mine/6s4e) | Structure of human MTHFD2 in complex with TH7299 | Descriptor: | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | Deposit date: | 2019-06-27 | Release date: | 2021-07-07 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer, 3, 2022
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6HXO
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6HXI
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6HXH
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![BU of 6hxh by Molmil](/molmil-images/mine/6hxh) | Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ... | Authors: | Verstraete, K, Verschueren, K. | Deposit date: | 2018-10-17 | Release date: | 2019-04-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
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6HXL
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6QCL
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6HXP
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6HXN
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6QFB
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6HXQ
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6HXM
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6HXK
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6HXJ
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