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Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic
Descriptor:	(14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate, Noranthrone synthase
Authors:	Tsai, S.C, Burkart, M.D, Townsend, C.A, Barajas, J.F, Shakya, G, Topper, C.L, Moreno, G, Jackson, D.R, Rivera, H, La Clair, J.J, Vagstad, A.
Deposit date:	2016-06-03
Release date:	2017-05-10
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.803 Å)
Cite:	Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH
Descriptor:	FORMIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ketoacyl reductase
Authors:	Korman, T.P, Javidpour, P, Tsai, S.-C.
Deposit date:	2011-02-18
Release date:	2011-05-25
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.792 Å)
Cite:	Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase. Biochemistry, 50, 2011

Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
Descriptor:	3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ketoacyl reductase
Authors:	Javidpour, P, Tsai, S.-C.
Deposit date:	2011-04-12
Release date:	2011-06-29
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.292 Å)
Cite:	Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase. Biochemistry, 50, 2011