6QDV
| Human post-catalytic P complex spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. | Deposit date: | 2019-01-03 | Release date: | 2019-02-20 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science, 363, 2019
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5MPS
| Structure of a spliceosome remodeled for exon ligation | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | Deposit date: | 2016-12-18 | Release date: | 2017-01-18 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Structure of a spliceosome remodelled for exon ligation. Nature, 542, 2017
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5MQ0
| Structure of a spliceosome remodeled for exon ligation | Descriptor: | 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ... | Authors: | Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K. | Deposit date: | 2016-12-19 | Release date: | 2017-01-18 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (4.17 Å) | Cite: | Structure of a spliceosome remodelled for exon ligation. Nature, 542, 2017
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5GAM
| Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ... | Authors: | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | Deposit date: | 2015-12-15 | Release date: | 2016-02-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution Nature, 530, 2016
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5GAN
| The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom | Descriptor: | 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ... | Authors: | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | Deposit date: | 2015-12-15 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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5GAO
| Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ... | Authors: | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | Deposit date: | 2015-12-15 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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4I43
| Crystal structure of Prp8:Aar2 complex | Descriptor: | A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | Authors: | Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K. | Deposit date: | 2012-11-27 | Release date: | 2013-01-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature, 493, 2013
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5LJ3
| Structure of the core of the yeast spliceosome immediately after branching | Descriptor: | CEF1, CLF1, CWC15, ... | Authors: | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | Deposit date: | 2016-07-17 | Release date: | 2016-08-03 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of the spliceosome immediately after branching. Nature, 537, 2016
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3ZEF
| Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution | Descriptor: | A1 CISTRON-SPLICING FACTOR AAR2, PRE-MRNA-SPLICING FACTOR 8 | Authors: | Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K. | Deposit date: | 2012-12-05 | Release date: | 2013-01-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of Prp8 Reveals Active Site Cavity of the Spliceosome Nature, 493, 2013
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5LJ5
| Overall structure of the yeast spliceosome immediately after branching. | Descriptor: | CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ... | Authors: | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | Deposit date: | 2016-07-17 | Release date: | 2016-08-31 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structure of the spliceosome immediately after branching. Nature, 537, 2016
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6EXN
| Post-catalytic P complex spliceosome with 3' splice site docked | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | Authors: | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | Deposit date: | 2017-11-08 | Release date: | 2018-01-17 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Science, 358, 2017
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4BGD
| Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8 | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Nguyen, T.H.D, Li, J, Nagai, K. | Deposit date: | 2013-03-25 | Release date: | 2013-05-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site Structure, 21, 2013
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5GAP
| Body region of the U4/U6.U5 tri-snRNP | Descriptor: | 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ... | Authors: | Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K. | Deposit date: | 2015-12-15 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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9FMD
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2K0A
| 1H, 15N and 13C chemical shift assignments for Rds3 protein | Descriptor: | Pre-mRNA-splicing factor RDS3, ZINC ION | Authors: | Loening, N, van Roon, A, Yang, J, Nagai, K, Neuhaus, D. | Deposit date: | 2008-01-31 | Release date: | 2008-07-22 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5LSB
| Crystal structure of yeast Hsh49p in complex with Cus1p binding domain. | Descriptor: | Cold sensitive U2 snRNA suppressor 1, Protein HSH49 | Authors: | van Roon, A.M, Obayashi, E, Sposito, B, Oubridge, C, Nagai, K. | Deposit date: | 2016-08-24 | Release date: | 2017-04-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. RNA, 23, 2017
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5LSL
| Crystal structure of yeast Hsh49p in complex with Cus1p binding domain. | Descriptor: | Cold sensitive U2 snRNA suppressor 1, Protein HSH49 | Authors: | van Roon, A.M, Obayashi, E, Sposito, B, Oubridge, C, Nagai, K. | Deposit date: | 2016-09-02 | Release date: | 2017-04-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. RNA, 23, 2017
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