1EVJ
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![BU of 1evj by Molmil](/molmil-images/mine/1evj) | CRYSTAL STRUCTURE OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE (GFOR) DELTA1-22 S64D | Descriptor: | GLUCOSE-FRUCTOSE OXIDOREDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Lott, J.S, Halbig, D, Baker, H.M, Hardman, M.J, Sprenger, G.A, Baker, E.N. | Deposit date: | 2000-04-20 | Release date: | 2000-12-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation. J.Mol.Biol., 304, 2000
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2GL0
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![BU of 2gl0 by Molmil](/molmil-images/mine/2gl0) | Structure of PAE2307 in complex with adenosine | Descriptor: | ADENOSINE, PHOSPHATE ION, conserved hypothetical protein | Authors: | Lott, J.S, Paget, B, Johnston, J.M, Baker, E.N. | Deposit date: | 2006-04-04 | Release date: | 2006-06-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The Structure of an Ancient Conserved Domain Establishes a Structural Basis for Stable Histidine Phosphorylation and Identifies a New Family of Adenosine-specific Kinases. J.Biol.Chem., 281, 2006
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1WVQ
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![BU of 1wvq by Molmil](/molmil-images/mine/1wvq) | Structure of conserved hypothetical protein PAE2307 from Pyrobaculum aerophilum | Descriptor: | PHOSPHATE ION, hypothetical protein PAE2307 | Authors: | Lott, J.S, Delbaere, L.T, Banfield, M.J, Sigrell-Simon, J.A, Baker, E.N. | Deposit date: | 2004-12-24 | Release date: | 2006-01-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases. J.Biol.Chem., 281, 2006
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4NF7
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4W1U
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![BU of 4w1u by Molmil](/molmil-images/mine/4w1u) | |
3UU1
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![BU of 3uu1 by Molmil](/molmil-images/mine/3uu1) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS142) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-3,5-dimethylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-11-27 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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2G5F
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![BU of 2g5f by Molmil](/molmil-images/mine/2g5f) | The structure of MbtI from Mycobacterium Tuberculosis, the first enzyme in the synthesis of Mycobactin, reveals it to be a salicylate synthase | Descriptor: | COG0147: Anthranilate/para-aminobenzoate synthases component I, GLYCEROL, IMIDAZOLE, ... | Authors: | Harrison, A.J, Lott, J.S, Yu, M, Ramsay, R, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2006-02-22 | Release date: | 2006-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of MbtI from Mycobacterium tuberculosis, the First Enzyme in the Biosynthesis of the Siderophore Mycobactin, Reveals It To Be a Salicylate Synthase J.Bacteriol., 188, 2006
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5KIS
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![BU of 5kis by Molmil](/molmil-images/mine/5kis) | YenB/RHS2 complex | Descriptor: | CALCIUM ION, CHLORIDE ION, RHS2, ... | Authors: | Busby, J.N, Hurst, M.R.H, Lott, J.S. | Deposit date: | 2016-06-16 | Release date: | 2017-08-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a new BC complex from Yersinia entomophaga To Be Published
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4DWS
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4OWV
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![BU of 4owv by Molmil](/molmil-images/mine/4owv) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with anthranilate | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-04 | Release date: | 2014-04-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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4OWQ
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![BU of 4owq by Molmil](/molmil-images/mine/4owq) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 3-methylanthranilate, PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-3-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-03 | Release date: | 2014-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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3VEH
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![BU of 3veh by Molmil](/molmil-images/mine/3veh) | Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT | Descriptor: | 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Bulloch, E.M, Chi, G, Manos-Turvey, A, Johnston, J.M, Baker, E.N, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-01-08 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51, 2012
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4A5Q
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![BU of 4a5q by Molmil](/molmil-images/mine/4a5q) | Crystal structure of the chitinase Chi1 fitted into the 3D structure of the Yersinia entomophaga toxin complex | Descriptor: | CHI1 | Authors: | Busby, J.N, Landsberg, M.J, Simpson, R.M, Jones, S.A, Hankamer, B, Hurst, M.R.H, Lott, J.S. | Deposit date: | 2011-10-27 | Release date: | 2011-11-16 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Structural Analysis of Chi1 Chitinase from Yen-Tc: The Multisubunit Insecticidal Abc Toxin Complex of Yersinia Entomophaga. J.Mol.Biol., 415, 2012
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3ITE
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![BU of 3ite by Molmil](/molmil-images/mine/3ite) | The third adenylation domain of the fungal SidN non-ribosomal peptide synthetase | Descriptor: | CHLORIDE ION, SULFATE ION, SidN siderophore synthetase | Authors: | Lee, T.V, Lott, J.S, Johnson, R.D, Johnson, L.J, Arcus, V.L. | Deposit date: | 2009-08-28 | Release date: | 2009-11-17 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis J.Biol.Chem., 285, 2010
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4GKM
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![BU of 4gkm by Molmil](/molmil-images/mine/4gkm) | Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (AnPRT; trpD) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxyphenyl)amino]-5-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-08-13 | Release date: | 2013-08-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6683 Å) | Cite: | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
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4GIU
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![BU of 4giu by Molmil](/molmil-images/mine/4giu) | Bianthranilate-like analogue bound in inner site of anthranilate phosphoribosyltransferase (AnPRT; trpD). | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-[(2-carboxy-5-methylphenyl)amino]-3-methylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-08-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.667 Å) | Cite: | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
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4IGL
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![BU of 4igl by Molmil](/molmil-images/mine/4igl) | Structure of the RHS-repeat containing BC component of the secreted ABC toxin complex from Yersinia entomophaga | Descriptor: | GLYCEROL, POTASSIUM ION, YenB, ... | Authors: | Busby, J.N, Panjikar, S, Landsberg, M.J, Hurst, M.R.H, Lott, J.S. | Deposit date: | 2012-12-17 | Release date: | 2013-08-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device Nature, 501, 2013
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4IJ1
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![BU of 4ij1 by Molmil](/molmil-images/mine/4ij1) | Bianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; trpD) in absence of substrates. | Descriptor: | 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-12-20 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15, 2014
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4X58
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![BU of 4x58 by Molmil](/molmil-images/mine/4x58) | Anthranilate phosphoribosyl transferase variant N138A from Mycobacterium tuberculosis in complex with PRPP and Mg | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, D-MALATE, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-04 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X59
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![BU of 4x59 by Molmil](/molmil-images/mine/4x59) | Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-04 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5A
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4X5E
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![BU of 4x5e by Molmil](/molmil-images/mine/4x5e) | Anthranilate phosphoribosyltransferase variant R194A from Mycobacterium tuberculosis with pyrophosphate, Mg2+ and anthranilate bound | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Evans, G.L, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-11-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5C
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![BU of 4x5c by Molmil](/molmil-images/mine/4x5c) | Anthranilate phosphoribosyltransferase variant R193L from Mycobacterium tuberculosis with pyrophosphate/PRPP and Mg2+ bound | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION, ... | Authors: | Cookson, T.V.M, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5D
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![BU of 4x5d by Molmil](/molmil-images/mine/4x5d) | Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis with anthranilate bound | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Cookson, T.V.M, Parker, E.J, Lott, J.S. | Deposit date: | 2014-12-05 | Release date: | 2015-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54, 2015
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4X5B
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![BU of 4x5b by Molmil](/molmil-images/mine/4x5b) | |