1JG8
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![BU of 1jg8 by Molmil](/molmil-images/mine/1jg8) | Crystal Structure of Threonine Aldolase (Low-specificity) | Descriptor: | CALCIUM ION, L-allo-threonine aldolase, SODIUM ION | Authors: | Kielkopf, C.L, Bonanno, J, Ray, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2001-06-23 | Release date: | 2001-07-04 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Low-specificity Threonine Aldolase, a Key Enzyme in Glycine Biosynthesis To be published
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1JMT
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![BU of 1jmt by Molmil](/molmil-images/mine/1jmt) | X-ray Structure of a Core U2AF65/U2AF35 Heterodimer | Descriptor: | HEXANE-1,6-DIOL, SPLICING FACTOR U2AF 35 KDA SUBUNIT, SPLICING FACTOR U2AF 65 KDA SUBUNIT | Authors: | Kielkopf, C.L, Rodionova, N.A, Green, M.R, Burley, S.K. | Deposit date: | 2001-07-19 | Release date: | 2001-09-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer. Cell(Cambridge,Mass.), 106, 2001
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1CVX
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![BU of 1cvx by Molmil](/molmil-images/mine/1cvx) | CRYSTAL STRUCTURE OF POLYAMIDE DIMER (IMPYHPPYBETADP)2 BOUND TO B-DNA DECAMER CCAGATCTGG | Descriptor: | 5'-D(*CP*CP*AP*GP*AP*TP*CP*TP*GP*G)-3', HYDROXYPYRROLE-IMIDAZOLE-PYRROLE POLYAMIDE | Authors: | Kielkopf, C.L, Bremer, R.E, White, S, Baird, E.E, Dervan, P.B, Rees, D.C. | Deposit date: | 1999-08-24 | Release date: | 2000-01-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J.Mol.Biol., 295, 2000
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1CVY
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![BU of 1cvy by Molmil](/molmil-images/mine/1cvy) | CRYSTAL STRUCTURE OF POLYAMIDE DIMER (IMPYPYPYBETADP)2 BOUND TO CCAGATCTGG | Descriptor: | 5'-D(*CP*CP*AP*GP*AP*TP*CP*TP*GP*G)-3', IMIDAZOLE-PYRROLE POLYAMIDE | Authors: | Kielkopf, C.L, Bremer, R.E, White, S, Baird, E.E, Dervan, P.B, Rees, D.C. | Deposit date: | 1999-08-24 | Release date: | 2000-01-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. J.Mol.Biol., 295, 2000
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1D8G
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![BU of 1d8g by Molmil](/molmil-images/mine/1d8g) | ULTRAHIGH RESOLUTION CRYSTAL STRUCTURE OF B-DNA DECAMER D(CCAGTACTGG) | Descriptor: | 5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*GP*)-3', CALCIUM ION | Authors: | Kielkopf, C.L, Ding, S, Kuhn, P, Rees, D.C. | Deposit date: | 1999-10-23 | Release date: | 2000-02-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (0.74 Å) | Cite: | Conformational flexibility of B-DNA at 0.74 A resolution: d(CCAGTACTGG)(2). J.Mol.Biol., 296, 2000
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1LW4
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![BU of 1lw4 by Molmil](/molmil-images/mine/1lw4) | |
1LW5
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![BU of 1lw5 by Molmil](/molmil-images/mine/1lw5) | |
408D
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![BU of 408d by Molmil](/molmil-images/mine/408d) | STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*TP*AP*CP*TP*GP*G)-3'), IMIDAZOLE-PYRROLE POLYAMIDE | Authors: | Kielkopf, C.L, White, S, Szewczyk, J.W, Turner, J.M, Baird, E.E, Dervan, P.B, Rees, D.C. | Deposit date: | 1998-06-24 | Release date: | 1998-10-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science, 282, 1998
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454D
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![BU of 454d by Molmil](/molmil-images/mine/454d) | INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3' | Descriptor: | 5'-D(*GP*(5IU)P*TP*GP*CP*AP*AP*C)-3', DELTA-ALPHA-RH[2R,9R-DIAMINO-4,7-DIAZADECANE]9,10-PHENANTHRENEQUINONE DIIMINE | Authors: | Kielkopf, C.L, Erkkila, K.E, Hudson, B.P, Barton, J.K, Rees, D.C. | Deposit date: | 1999-03-03 | Release date: | 2000-02-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure of a photoactive rhodium complex intercalated into DNA. Nat.Struct.Biol., 7, 2000
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365D
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![BU of 365d by Molmil](/molmil-images/mine/365d) | STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*GP*(CBR)P*CP*TP*GP*G)-3'), IMIDAZOLE-PYRROLE POLYAMIDE | Authors: | Kielkopf, C.L, Baird, E.E, Dervan, P.B, Rees, D.C. | Deposit date: | 1997-12-17 | Release date: | 1998-02-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for G.C recognition in the DNA minor groove. Nat.Struct.Biol., 5, 1998
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1M6S
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![BU of 1m6s by Molmil](/molmil-images/mine/1m6s) | Crystal Structure Of Threonine Aldolase | Descriptor: | CALCIUM ION, CHLORIDE ION, L-allo-threonine aldolase | Authors: | Burley, S.K, Kielkopf, C.L. | Deposit date: | 2002-07-17 | Release date: | 2002-12-11 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray Structures of Threonine Aldolase Complexes: Structural Basis of Substrate Recognition Biochemistry, 41, 2002
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2HZC
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![BU of 2hzc by Molmil](/molmil-images/mine/2hzc) | |
7SN6
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![BU of 7sn6 by Molmil](/molmil-images/mine/7sn6) | U2AF65 UHM BOUND TO SF3B155 ULM5 | Descriptor: | ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2021-10-27 | Release date: | 2022-07-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
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1XCB
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![BU of 1xcb by Molmil](/molmil-images/mine/1xcb) | X-ray Structure of a Rex-Family Repressor/NADH Complex from Thermus Aquaticus | Descriptor: | CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor rex | Authors: | Sickmier, E.A, Brekasis, D, Paranawithana, S, Bonanno, J.B, Burley, S.K, Paget, M.S, Kielkopf, C.L, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2004-09-01 | Release date: | 2004-09-28 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | X-Ray Structure of a Rex-Family Repressor/NADH Complex: Insights into the Mechanism of Redox Sensing Structure, 13, 2005
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7S3A
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![BU of 7s3a by Molmil](/molmil-images/mine/7s3a) | |
6N3D
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![BU of 6n3d by Molmil](/molmil-images/mine/6n3d) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State) | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6N3F
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![BU of 6n3f by Molmil](/molmil-images/mine/6n3f) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Leach, J.R, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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6NSX
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![BU of 6nsx by Molmil](/molmil-images/mine/6nsx) | |
6N3E
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![BU of 6n3e by Molmil](/molmil-images/mine/6n3e) | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4 | Descriptor: | FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ... | Authors: | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2018-11-15 | Release date: | 2019-01-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. J. Biol. Chem., 294, 2019
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5W0H
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![BU of 5w0h by Molmil](/molmil-images/mine/5w0h) | |
5W0G
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![BU of 5w0g by Molmil](/molmil-images/mine/5w0g) | Structure of U2AF65 (U2AF2) RRM1 at 1.07 resolution | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, Splicing factor U2AF 65 kDa subunit, ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2017-05-30 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. Biochemistry, 56, 2017
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6XLW
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![BU of 6xlw by Molmil](/molmil-images/mine/6xlw) | Crystal structure of U2AF65 bound to AdML splice site sequence | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, ... | Authors: | Maji, D, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2020-06-29 | Release date: | 2020-10-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J.Biol.Chem., 295, 2020
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4TU9
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![BU of 4tu9 by Molmil](/molmil-images/mine/4tu9) | STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DG*U)-3'), GLYCEROL, ... | Authors: | Jenkins, J.L, McLaughlin, K.J, Agrawal, A.A, Kielkopf, C.L. | Deposit date: | 2014-06-24 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
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4TU8
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![BU of 4tu8 by Molmil](/molmil-images/mine/4tu8) | STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DA*U)-3'), ... | Authors: | MCLAUGHLIN, K.J, JENKINS, J.L, Agrawal, A.A, KIELKOPF, C.L. | Deposit date: | 2014-06-24 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.918 Å) | Cite: | Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
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4TU7
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![BU of 4tu7 by Molmil](/molmil-images/mine/4tu7) | Structure of U2AF65 D231V variant with BrU5 DNA | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ... | Authors: | Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L. | Deposit date: | 2014-06-24 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proc.Natl.Acad.Sci.USA, 111, 2014
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