1MS5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms5 by Molmil](/molmil-images/mine/1ms5) | Triclinic form of Trypanosoma cruzi trans-sialidase, soaked with N-acetylneuraminyl-a-2,3-thio-galactoside (NA-S-Gal) | Descriptor: | trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MS0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms0 by Molmil](/molmil-images/mine/1ms0) | Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)and lactose | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MZ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mz6 by Molmil](/molmil-images/mine/1mz6) | Trypanosoma rangeli sialidase in complex with the inhibitor DANA | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | Deposit date: | 2002-10-05 | Release date: | 2002-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases Embo J., 19, 2000
|
|
1MS3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms3 by Molmil](/molmil-images/mine/1ms3) | Monoclinic form of Trypanosoma cruzi trans-sialidase | Descriptor: | trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MZ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mz5 by Molmil](/molmil-images/mine/1mz5) | Trypanosoma rangeli sialidase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | Deposit date: | 2002-10-05 | Release date: | 2002-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases Embo J., 19, 2000
|
|
1MR5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mr5 by Molmil](/molmil-images/mine/1mr5) | Orthorhombic form of Trypanosoma cruzi trans-sialidase | Descriptor: | trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-18 | Release date: | 2003-03-18 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MS8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms8 by Molmil](/molmil-images/mine/1ms8) | Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MS1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms1 by Molmil](/molmil-images/mine/1ms1) | Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MS9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms9 by Molmil](/molmil-images/mine/1ms9) | Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with lactose | Descriptor: | beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme of Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1MS4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ms4 by Molmil](/molmil-images/mine/1ms4) | Triclinic form of Trypanosoma cruzi trans-sialidase | Descriptor: | trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
|
|
1S0J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s0j by Molmil](/molmil-images/mine/1s0j) | Trypanosoma cruzi trans-sialidase in complex with MuNANA (Michaelis complex) | Descriptor: | 4-METHYL-2-OXO-2H-CHROMEN-7-YL 5-(ACETYLAMINO)-3,5-DIDEOXY-L-ERYTHRO-NON-2-ULOPYRANOSIDONIC ACID, trans-sialidase | Authors: | Amaya, M.F, Watts, A.G, Damager, I, Wehenkel, A, Nguyen, T, Buschiazzo, A, Paris, G, Frasch, A.C, Withers, S.G, Alzari, P.M. | Deposit date: | 2003-12-31 | Release date: | 2004-05-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase. Structure, 12, 2004
|
|
1S0I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1s0i by Molmil](/molmil-images/mine/1s0i) | Trypanosoma cruzi trans-sialidase in complex with sialyl-lactose (Michaelis complex) | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, trans-sialidase | Authors: | Amaya, M.F, Watts, A.G, Damager, I, Wehenkel, A, Nguyen, T, Buschiazzo, A, Paris, G, Frasch, A.C, Withers, S.G, Alzari, P.M. | Deposit date: | 2003-12-31 | Release date: | 2004-05-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase. Structure, 12, 2004
|
|
1N1T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1t by Molmil](/molmil-images/mine/1n1t) | Trypanosoma rangeli sialidase in complex with DANA at 1.6 A | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-20 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase J.Mol.Biol., 325, 2003
|
|
1N1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1y by Molmil](/molmil-images/mine/1n1y) | Trypanosoma rangeli sialidase in complex with sialic acid | Descriptor: | N-acetyl-alpha-neuraminic acid, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-21 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The high resolution structures of free and inhibitor-bound
Trypanosoma rangeli sialidase and its comparison with T.
cruzi trans-sialidase J.Mol.Biol., 325, 2003
|
|
1N1V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1v by Molmil](/molmil-images/mine/1n1v) | Trypanosoma rangeli sialidase in complex with DANA | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-21 | Release date: | 2003-01-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T.
cruzi trans-sialidase J.Mol.Biol., 325, 2003
|
|
1N1S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1n1s by Molmil](/molmil-images/mine/1n1s) | Trypanosoma rangeli sialidase | Descriptor: | SULFATE ION, Sialidase | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | Deposit date: | 2002-10-20 | Release date: | 2003-01-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase J.Mol.Biol., 325, 2003
|
|