5WBW
| Yeast Hsp104 fragment 1-360 | Descriptor: | Heat shock protein 104 | Authors: | Lee, S. | Deposit date: | 2017-06-29 | Release date: | 2018-01-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase. Biosci. Rep., 37, 2017
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8U0T
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4UIP
| The complex structure of extracellular domain of EGFR with Repebody (rAC1). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIDERMAL GROWTH FACTOR RECEPTOR, ... | Authors: | Kang, Y.J, Cha, Y.J, Cho, H.S, Lee, J.J, Kim, H.S. | Deposit date: | 2015-03-31 | Release date: | 2015-11-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy. Angew.Chem.Int.Ed.Engl., 54, 2015
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6P79
| Engineered single chain antibody C9+C14 ScFv | Descriptor: | Engineered antibody heavy chain, Engineered antibody light chain | Authors: | Zhang, Y, Li, W, Marshall, N. | Deposit date: | 2019-06-05 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.583 Å) | Cite: | Computer-based Engineering of Thermostabilized Antibody Fragments. Aiche J, 66, 2020
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4J4L
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8K06
| Pseudouridine 5'-monophosphate glycosylase from Arabidopsis thaliana -- PSU, R5P bound K185A mutant | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, MANGANESE (II) ION, PSEUDOURIDINE-5'-MONOPHOSPHATE, ... | Authors: | Lee, J.Y, Kim, S.H, Rhee, S.K. | Deposit date: | 2023-07-07 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | Structure and function of the pseudouridine 5'-monophosphate glycosylase PUMY from Arabidopsis thaliana. Rna Biol., 21, 2024
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8K05
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8K07
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7YLK
| Myoglobin containing Ir complex | Descriptor: | Myoglobin, SULFATE ION, delta-{1-([2,2'-bipyridin]-5-ylmethyl)pyrrolidine-2,5-dione}bis[2-(2,4-difluorophenyl)pyridine)]iridium(III), ... | Authors: | Lee, J.H, Song, W.J. | Deposit date: | 2022-07-26 | Release date: | 2023-03-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Photocatalytic C-O Coupling Enzymes That Operate via Intramolecular Electron Transfer. J.Am.Chem.Soc., 145, 2023
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3IX9
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6AMN
| Crystal Structure of Hsp104 N Domain | Descriptor: | Heat shock protein 104 | Authors: | Lee, S. | Deposit date: | 2017-08-10 | Release date: | 2017-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.816 Å) | Cite: | Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation. Sci Rep, 7, 2017
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4KWC
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4KVZ
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2OXL
| Structure and Function of the E. coli Protein YmgB: a Protein Critical for Biofilm Formation and Acid Resistance | Descriptor: | Hypothetical protein ymgB, octyl beta-D-glucopyranoside | Authors: | Page, R, Peti, W, Woods, T.K, Palermino, J.M, Doshi, O. | Deposit date: | 2007-02-20 | Release date: | 2007-10-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Function of the Escherichia coli Protein YmgB: A Protein Critical for Biofilm Formation and Acid-resistance. J.Mol.Biol., 373, 2007
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8IVU
| Crystal Structure of Human NAMPT in complex with A4276 | Descriptor: | N-[[4-(6-methyl-1,3-benzoxazol-2-yl)phenyl]methyl]pyridine-3-carboxamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | Authors: | Kang, B.G, Cha, S.S. | Deposit date: | 2023-03-28 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.09000921 Å) | Cite: | Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy. Theranostics, 13, 2023
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4ECM
| 2.3 Angstrom Crystal Structure of a Glucose-1-phosphate Thymidylyltransferase from Bacillus anthracis in Complex with Thymidine-5-diphospho-alpha-D-glucose and Pyrophosphate | Descriptor: | 2'DEOXY-THYMIDINE-5'-DIPHOSPHO-ALPHA-D-GLUCOSE, Glucose-1-phosphate thymidylyltransferase, PYROPHOSPHATE 2- | Authors: | Minasov, G, Kuhn, M, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-03-26 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA). Acta Crystallogr F Struct Biol Commun, 73, 2017
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2QBS
| Crystal structure of ptp1b-inhibitor complex | Descriptor: | 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W. | Deposit date: | 2007-06-18 | Release date: | 2008-03-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50, 2007
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5X1E
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8TRC
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8TR2
| mGluR3 in the presence of the agonist LY379268 | Descriptor: | (1S,4R,5R,6S)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, CALCIUM ION, Metabotropic glutamate receptor 3 | Authors: | Strauss, A, Levitz, J. | Deposit date: | 2023-08-09 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. Biorxiv, 2023
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8TQB
| mGluR3 in the presence of the agonist LY379268 and PAM VU6023326 | Descriptor: | (1R,4R,5S,6R)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, CALCIUM ION, Metabotropic glutamate receptor 3 | Authors: | Strauss, A, Levitz, J. | Deposit date: | 2023-08-06 | Release date: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. Biorxiv, 2023
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8TR0
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8TRD
| mGluR3 class 1 in the presence of the antagonist LY 341495 | Descriptor: | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, Metabotropic glutamate receptor 3 | Authors: | Strauss, A, Levitz, J. | Deposit date: | 2023-08-09 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization. Nat Commun, 15, 2024
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4MAN
| Bcl_2-Navitoclax Analog (with Indole) Complex | Descriptor: | 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide, Apoptosis regulator Bcl-2 | Authors: | Park, C.H. | Deposit date: | 2013-08-16 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
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6XFP
| Crystal Structure of BRAF kinase domain bound to Belvarafenib | Descriptor: | 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide, CHLORIDE ION, Serine/threonine-protein kinase B-raf | Authors: | Yin, J, Sudhamsu, J. | Deposit date: | 2020-06-16 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. Nature, 594, 2021
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