5TP0
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![BU of 5tp0 by Molmil](/molmil-images/mine/5tp0) | Human mesotrypsin in complex with diminazene | Descriptor: | BERENIL, CALCIUM ION, SULFATE ION, ... | Authors: | Kayode, O, Soares, A, Radisky, E.S. | Deposit date: | 2016-10-19 | Release date: | 2017-05-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Small molecule inhibitors of mesotrypsin from a structure-based docking screen. PLoS ONE, 12, 2017
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8TS0
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7DDD
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![BU of 7ddd by Molmil](/molmil-images/mine/7ddd) | SARS-Cov2 S protein at close state | Descriptor: | Spike glycoprotein | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2020-10-28 | Release date: | 2020-11-25 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
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7DK7
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7DCX
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![BU of 7dcx by Molmil](/molmil-images/mine/7dcx) | |
7DK6
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![BU of 7dk6 by Molmil](/molmil-images/mine/7dk6) | |
7DD8
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8URF
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![BU of 8urf by Molmil](/molmil-images/mine/8urf) | |
7DK5
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![BU of 7dk5 by Molmil](/molmil-images/mine/7dk5) | |
7DCC
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![BU of 7dcc by Molmil](/molmil-images/mine/7dcc) | |
7KD7
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![BU of 7kd7 by Molmil](/molmil-images/mine/7kd7) | |
7KPU
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![BU of 7kpu by Molmil](/molmil-images/mine/7kpu) | |
4KXF
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6BIH
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![BU of 6bih by Molmil](/molmil-images/mine/6bih) | The Structure of the Actin-Smooth Muscle Myosin Motor Domain Complex in the Rigor State | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Taylor, K.A, Banerjee, C, Hu, Z. | Deposit date: | 2017-11-02 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | The structure of the actin-smooth muscle myosin motor domain complex in the rigor state. J. Struct. Biol., 200, 2017
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6B8U
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![BU of 6b8u by Molmil](/molmil-images/mine/6b8u) | Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor | Descriptor: | Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Authors: | Appleton, B.A, Murray, J, Shafer, C.M. | Deposit date: | 2017-10-09 | Release date: | 2017-11-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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7CH1
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![BU of 7ch1 by Molmil](/molmil-images/mine/7ch1) | The overall structure of SLC26A9 | Descriptor: | CHLORIDE ION, SODIUM ION, Solute carrier family 26 member 9 | Authors: | Chi, X.M, Chen, Y, Li, X.R, Zhang, Y.Y, Zhou, Q. | Deposit date: | 2020-07-03 | Release date: | 2020-08-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discov, 6, 2020
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1I5U
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![BU of 1i5u by Molmil](/molmil-images/mine/1i5u) | SOLUTION STRUCTURE OF CYTOCHROME B5 TRIPLE MUTANT (E48A/E56A/D60A) | Descriptor: | CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Qian, C, Yao, Y, Tang, W, Wang, J, Zhongxian, H. | Deposit date: | 2001-02-28 | Release date: | 2001-03-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Effects of charged amino-acid mutation on the solution structure of cytochrome b(5) and binding between cytochrome b(5) and cytochrome c. Protein Sci., 10, 2001
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6VHG
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![BU of 6vhg by Molmil](/molmil-images/mine/6vhg) | Crystal structure of phosphorylated RET tyrosine kinase domain complexed with a pyrazolo[1,5-a]pyrimidine inhibitor | Descriptor: | 3-(3,4-dimethoxyphenyl)-N~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine, ACETATE ION, CHLORIDE ION, ... | Authors: | Lee, C.C, Spraggon, G. | Deposit date: | 2020-01-09 | Release date: | 2020-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma. Acs Med.Chem.Lett., 11, 2020
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8GZ1
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![BU of 8gz1 by Molmil](/molmil-images/mine/8gz1) | Cryo-EM structure of human NaV1.6/beta1/beta2,apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Sodium channel protein type 8 subunit alpha, ... | Authors: | Li, Y, Jiang, D. | Deposit date: | 2022-09-24 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
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8GZ2
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![BU of 8gz2 by Molmil](/molmil-images/mine/8gz2) | Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin | Descriptor: | (1R,2S,3S,4R,5R,9S,11S,12S,14R)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 8 subunit alpha, ... | Authors: | Li, Y, Jiang, D. | Deposit date: | 2022-09-24 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of human Na V 1.6 channel reveals Na + selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun, 14, 2023
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6UYA
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![BU of 6uya by Molmil](/molmil-images/mine/6uya) | Crystal structure of Compound 19 bound to IRAK4 | Descriptor: | Interleukin-1 receptor-associated kinase 4, N-{2-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, SULFATE ION | Authors: | Kiefer, J.R, Bryan, M.C, Lupardus, P.J, Zarrin, A.A, Rajapaksa, N.S, Gobbi, A, Drobnick, J, Kolesnikov, A, Liang, J, Do, S. | Deposit date: | 2019-11-12 | Release date: | 2019-11-20 | Last modified: | 2020-04-01 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Med.Chem.Lett., 11, 2020
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5UHN
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5UGX
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5UGL
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8HKQ
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![BU of 8hkq by Molmil](/molmil-images/mine/8hkq) | ion channel | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2022-11-27 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of human Slo2.2 channel gating and modulation. Cell Rep, 42, 2023
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