1YD4
| Crystal structure of the GIY-YIG N-terminal endonuclease domain of UvrC from Thermotoga maritima: Point mutant Y29F bound to its catalytic divalent cation | Descriptor: | MANGANESE (II) ION, UvrABC system protein C | Authors: | Truglio, J.J, Rhau, B, Croteau, D.L, Wang, L, Skorvaga, M, Karakas, E, DellaVecchia, M.J, Wang, H, Van Houten, B, Kisker, C. | Deposit date: | 2004-12-23 | Release date: | 2005-03-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into the first incision reaction during nucleotide excision repair Embo J., 24, 2005
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3TKR
| Crystal structure of full-length human peroxiredoxin 4 with T118E mutation | Descriptor: | Peroxiredoxin-4 | Authors: | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | Deposit date: | 2011-08-28 | Release date: | 2011-10-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TKS
| Crystal structure of full-length human peroxiredoxin 4 in three different redox states | Descriptor: | PEROXIDE ION, Peroxiredoxin-4 | Authors: | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | Deposit date: | 2011-08-28 | Release date: | 2011-10-05 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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3TKP
| Crystal structure of full-length human peroxiredoxin 4 in the reduced form | Descriptor: | Peroxiredoxin-4 | Authors: | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | Deposit date: | 2011-08-28 | Release date: | 2011-10-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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6V51
| Spin-labeled T4 Lysozyme (9/131FnbY)-(4-Amino-TEMPO) | Descriptor: | 4-amino-2,2,6,6-tetramethylpiperidin-1-ol, Endolysin | Authors: | Liu, J, Morizumi, T, Ou, W.L, Wang, L, Ernst, O.P. | Deposit date: | 2019-12-02 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. J.Am.Chem.Soc., 142, 2020
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8JQ9
| Novel Anti-phage System | Descriptor: | Endonuclease GajA | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JQB
| Structure of Gabija GajA-GajB 4:4 Complex | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JQC
| Novel Anti-phage System | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-06-13 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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3MCB
| Crystal structure of NAC domains of human nascent polypeptide-associated complex (NAC) | Descriptor: | IODIDE ION, Nascent polypeptide-associated complex subunit alpha, Transcription factor BTF3 | Authors: | Wang, L.F, Zhang, W.C, Wang, L, Zhang, X.J.C, Li, X.M, Rao, Z. | Deposit date: | 2010-03-29 | Release date: | 2010-07-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit Protein Cell, 1, 2010
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3MCE
| Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated complex(NAC) | Descriptor: | IODIDE ION, Nascent polypeptide-associated complex subunit alpha | Authors: | Wang, L.F, Zhang, W.C, Wang, L, Zhang, X.J.C, Li, X.M, Rao, Z. | Deposit date: | 2010-03-29 | Release date: | 2010-07-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit Protein Cell, 1, 2010
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3TKQ
| Crystal structure of full-length human peroxiredoxin 4 with mixed conformation | Descriptor: | Peroxiredoxin-4 | Authors: | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | Deposit date: | 2011-08-28 | Release date: | 2011-10-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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4RED
| Crystal structure of human AMPK alpha1 KD-AID with K43A mutation | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Authors: | Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. | Deposit date: | 2014-09-22 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
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4RER
| Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, ... | Authors: | Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. | Deposit date: | 2014-09-23 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.047 Å) | Cite: | Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
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8KDC
| Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form | Descriptor: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | Authors: | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | Deposit date: | 2023-08-09 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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8KDB
| Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form | Descriptor: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | Authors: | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | Deposit date: | 2023-08-09 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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4REW
| Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex | Descriptor: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | Authors: | Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. | Deposit date: | 2014-09-24 | Release date: | 2014-12-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4.58 Å) | Cite: | Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
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3R7W
| Crystal Structure of Gtr1p-Gtr2p complex | Descriptor: | GTP-binding protein GTR1, GTP-binding protein GTR2, MAGNESIUM ION, ... | Authors: | Gong, R, Li, L, Liu, Y, Wang, P, Yang, H, Wang, L, Cheng, J, Guan, K.L, Xu, Y. | Deposit date: | 2011-03-23 | Release date: | 2011-08-24 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.773 Å) | Cite: | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation Genes Dev., 25, 2011
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8WJL
| Cryo-EM structure of 6-subunit Smc5/6 hinge region | Descriptor: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, Structural maintenance of chromosomes protein 6 | Authors: | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | Deposit date: | 2023-09-26 | Release date: | 2024-06-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6.15 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8WJO
| Cryo-EM structure of 8-subunit Smc5/6 arm region | Descriptor: | DNA repair protein KRE29, E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, ... | Authors: | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | Deposit date: | 2023-09-26 | Release date: | 2024-06-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6.04 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8WJN
| Cryo-EM structure of 6-subunit Smc5/6 head region | Descriptor: | Non-structural maintenance of chromosome element 3, Non-structural maintenance of chromosomes element 1, Non-structural maintenance of chromosomes element 4, ... | Authors: | Li, Q, Zhang, J, Zhang, X, Cheng, T, Wang, Z, Jin, D, Chen, Z, Wang, L. | Deposit date: | 2023-09-26 | Release date: | 2024-06-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.58 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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4KFP
| Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | Descriptor: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | Authors: | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | Deposit date: | 2013-04-27 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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6NPY
| Cryo-EM structure of NLRP3 bound to NEK7 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ... | Authors: | Sharif, H, Wang, L, Wang, W.L, Wu, H. | Deposit date: | 2019-01-18 | Release date: | 2019-06-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature, 570, 2019
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7WEC
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7WE7
| SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 282, ... | Authors: | Wang, X, Wang, L. | Deposit date: | 2021-12-23 | Release date: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants. Nature, 603, 2022
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7WEE
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