6JZ8
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![BU of 6jz8 by Molmil](/molmil-images/mine/6jz8) | b-glucuronidase from Ruminococcus gnavus in complex with D-glucaro 1,5-lactone | Descriptor: | (2S,3S,4S,5R)-3,4,5-trihydroxy-6-oxo-oxane-2-carboxylic acid, Beta-glucuronidase | Authors: | Dashnyam, P, Lin, H.Y. | Deposit date: | 2019-04-30 | Release date: | 2020-06-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.583 Å) | Cite: | Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
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6JZ3
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![BU of 6jz3 by Molmil](/molmil-images/mine/6jz3) | b-glucuronidase from Ruminococcus gnavus in complex with uronic deoxynojirimycin | Descriptor: | (2~{S},3~{R},4~{R},5~{S})-3,4,5-tris(oxidanyl)piperidine-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, Beta-glucuronidase | Authors: | Dashnyam, P, Lin, H.Y. | Deposit date: | 2019-04-30 | Release date: | 2020-05-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.502 Å) | Cite: | Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
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5YWK
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![BU of 5ywk by Molmil](/molmil-images/mine/5ywk) | Crystal structure of Arabidopsis thaliana HPPD complexed with Benquitrione-Methyl | Descriptor: | 1,5-dimethyl-3-(2-methylphenyl)-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Yang, W.C, Lin, H.Y. | Deposit date: | 2017-11-29 | Release date: | 2019-01-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.804 Å) | Cite: | Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide. J.Agric.Food Chem., 69, 2021
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6JZ4
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![BU of 6jz4 by Molmil](/molmil-images/mine/6jz4) | b-glucuronidase from Ruminococcus gnavus in complex with D-glucaro-d-lactam | Descriptor: | (2S,3R,4S,5R)-3,4,5-trihydroxy-6-oxopiperidine-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, Beta-glucuronidase | Authors: | Dashnyam, P, Lin, H.Y. | Deposit date: | 2019-04-30 | Release date: | 2020-06-03 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.712 Å) | Cite: | Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
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7RK3
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![BU of 7rk3 by Molmil](/molmil-images/mine/7rk3) | |
6JZ7
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![BU of 6jz7 by Molmil](/molmil-images/mine/6jz7) | |
5YWH
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![BU of 5ywh by Molmil](/molmil-images/mine/5ywh) | Crystal structure of Arabidopsis thaliana HPPD complexed with Y13508 | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, FE (III) ION, [1,3-diethyl-2,2-bis(oxidanylidene)-2$l^{6},1,3-benzothiadiazol-5-yl]-(1-methyl-5-oxidanyl-pyrazol-4-yl)methanone | Authors: | Yang, W.C, Lin, H.Y. | Deposit date: | 2017-11-29 | Release date: | 2019-01-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Crystal structure of Arabidopsis thaliana HPPD complexed with Y13508 To be published
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6JZ6
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![BU of 6jz6 by Molmil](/molmil-images/mine/6jz6) | b-glucuronidase from Ruminococcus gnavus in complex with C6-substituted uronic isofagomine | Descriptor: | (2~{S},3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-2-propyl-piperidine-3-carboxylic acid, Beta-glucuronidase | Authors: | Dashnyam, P, Lin, H.Y. | Deposit date: | 2019-04-30 | Release date: | 2020-06-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.605 Å) | Cite: | Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63, 2020
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6JZ1
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![BU of 6jz1 by Molmil](/molmil-images/mine/6jz1) | |
8IM2
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![BU of 8im2 by Molmil](/molmil-images/mine/8im2) | Crystal structure of human HPPD complexed with NTBC | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, 4-hydroxyphenylpyruvate dioxygenase, ... | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-03-05 | Release date: | 2023-10-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors. Structure, 31, 2023
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5GKB
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![BU of 5gkb by Molmil](/molmil-images/mine/5gkb) | Crystal Structure of Fatty Acid-Binding Protein in Brain Tissue of Drosophila melanogaster without citrate inside | Descriptor: | Fatty acid bindin protein, isoform B | Authors: | Cheng, Y.-Y, Huang, Y.-F, Lin, H.-H, Chang, W.W, Lyu, P.-C. | Deposit date: | 2016-07-04 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport. Biochim Biophys Acta Mol Cell Biol Lipids, 1864, 2019
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5GGE
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![BU of 5gge by Molmil](/molmil-images/mine/5gge) | Fatty Acid-Binding Protein in Brain Tissue of Drosophila melanogaster | Descriptor: | CITRIC ACID, Fatty acid bindin protein, isoform B | Authors: | Cheng, Y.-Y, Huang, Y.-F, Lin, H.-H, Chang, W.W, Lyu, P.-C. | Deposit date: | 2016-06-15 | Release date: | 2017-06-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.861 Å) | Cite: | The ligand-mediated affinity of brain-type fatty acid-binding protein for membranes determines the directionality of lipophilic cargo transport. Biochim Biophys Acta Mol Cell Biol Lipids, 1864, 2019
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4MT6
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![BU of 4mt6 by Molmil](/molmil-images/mine/4mt6) | |
6ENT
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![BU of 6ent by Molmil](/molmil-images/mine/6ent) | Structure of the rat RKIP variant delta143-146 | Descriptor: | CHLORIDE ION, Phosphatidylethanolamine-binding protein 1, ZINC ION | Authors: | Koelmel, W, Hirschbeck, M, Schindelin, H, Lorenz, K, Kisker, C. | Deposit date: | 2017-10-06 | Release date: | 2017-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8HZA
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![BU of 8hza by Molmil](/molmil-images/mine/8hza) | Crystal structure of AtHPPD-YH20326 complex | Descriptor: | 1,4-dimethyl-3-(oxan-4-ylmethyl)-5-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-benzimidazol-2-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-08 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal structure of AtHPPD-YH20326 complex To Be Published
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8HXH
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![BU of 8hxh by Molmil](/molmil-images/mine/8hxh) | Crystal structure of AtHPPD-Y18024 complex | Descriptor: | 1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-propyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-04 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Crystal structure of AtHPPD-Y18024 complex To Be Published
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8HYS
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![BU of 8hys by Molmil](/molmil-images/mine/8hys) | Crystal structure of AtHPPD-Y19802 complex | Descriptor: | 1-methyl-3-[2-methyl-6-methylsulfonyl-3-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-phenyl]-6-(trifluoromethyl)pyrimidine-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-07 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of AtHPPD-Y19802 complex To Be Published
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8HWR
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![BU of 8hwr by Molmil](/molmil-images/mine/8hwr) | Crystal structure of AtHPPD-Y191193 complex | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, 6-chloranyl-3-cyclopentyl-1-methyl-7-(2-oxidanyl-6-oxidanylidene-cyclohexa-1,3-dien-1-yl)carbonyl-quinazoline-2,4-dione, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-02 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Crystal structure of AtHPPD-Y191193 complex To Be Published
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8HYP
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![BU of 8hyp by Molmil](/molmil-images/mine/8hyp) | Crystal structure of AtHPPD-Y18400 complex | Descriptor: | 3-[(4-fluorophenyl)methyl]-1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-07 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | Crystal structure of AtHPPD-Y18400 complex To Be Published
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8HZ7
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![BU of 8hz7 by Molmil](/molmil-images/mine/8hz7) | Crystal structure of AtHPPD-Y181135 complex | Descriptor: | 3-butyl-5-methyl-6-[(2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,2,3-benzotriazin-4-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-08 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Crystal structure of AtHPPD-Y181135 complex To Be Published
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8I0G
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![BU of 8i0g by Molmil](/molmil-images/mine/8i0g) | Crystal structure of AtHPPD-Y19543 complex | Descriptor: | 3-[(4-fluorophenyl)methyl]-5-methyl-6-[(2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,2,3-benzotriazin-4-one, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-10 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.992 Å) | Cite: | Crystal structure of AtHPPD-Y19543 complex To Be Published
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8I36
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![BU of 8i36 by Molmil](/molmil-images/mine/8i36) | Crystal structure of AtHPPD-Y18980 complex | Descriptor: | 1,5-dimethyl-3-(naphthalen-1-ylmethyl)-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-16 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.887 Å) | Cite: | Crystal structure of AtHPPD-Y18980 complex To Be Published
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8I2P
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![BU of 8i2p by Molmil](/molmil-images/mine/8i2p) | Crystal structure of AtHPPD-Y19060 complex | Descriptor: | 3-(cyclopropylmethyl)-6-[(5-cyclopropyl-2-methyl-3-oxidanylidene-1H-pyrazol-4-yl)carbonyl]-1,5-dimethyl-quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-14 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.797 Å) | Cite: | Crystal structure of AtHPPD-Y19060 complex To Be Published
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8HXF
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![BU of 8hxf by Molmil](/molmil-images/mine/8hxf) | Crystal structure of AtHPPD-Y181188 complex | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, 6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-4-[[4-(trifluoromethyl)phenyl]methyl]-1,4-benzothiazin-3-one, COBALT (II) ION | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-04 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | Crystal structure of AtHPPD-Y181188 complex To Be Published
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8HX4
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![BU of 8hx4 by Molmil](/molmil-images/mine/8hx4) | Crystal structure of AtHPPD-Y18549 complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-hydroxyphenylpyruvate dioxygenase, 6-[(R)-[(2R,6R)-2,6-bis(oxidanyl)cyclohexyl]-oxidanyl-methyl]-3-(4,6-dimethylpyrimidin-2-yl)-1,5-dimethyl-quinazoline-2,4-dione, ... | Authors: | Dong, J, Lin, H.-Y, Yang, G.-F. | Deposit date: | 2023-01-03 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.896 Å) | Cite: | Crystal structure of AtHPPD-Y18549 complex To Be Published
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