6JZ6

b-glucuronidase from Ruminococcus gnavus in complex with C6-substituted uronic isofagomine

Summary for 6JZ6

Entry DOI	10.2210/pdb6jz6/pdb
Descriptor	Beta-glucuronidase, (2~{S},3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-2-propyl-piperidine-3-carboxylic acid (3 entities in total)
Functional Keywords	b-glucuronidase, hydrolase
Biological source	Ruminococcus gnavus
Total number of polymer chains	2
Total formula weight	140484.24
Authors	Dashnyam, P.,Lin, H.Y. (deposition date: 2019-04-30, release date: 2020-06-10, Last modification date: 2023-11-22)
Primary citation	Dashnyam, P.,Lin, H.Y.,Chen, C.Y.,Gao, S.,Yeh, L.F.,Hsieh, W.C.,Tu, Z.,Lin, C.H. Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes. J.Med.Chem., 63:4617-4627, 2020 Cited by PubMed: 32105467 DOI: 10.1021/acs.jmedchem.9b01918 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.605 Å)

Structure validation