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6XFP
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BU of 6xfp by Molmil
Crystal Structure of BRAF kinase domain bound to Belvarafenib
Descriptor: 4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide, CHLORIDE ION, Serine/threonine-protein kinase B-raf
Authors:Yin, J, Sudhamsu, J.
Deposit date:2020-06-16
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma.
Nature, 594, 2021
6M84
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BU of 6m84 by Molmil
Crystal structure of cKir2.2 force open mutant in complex with PI(4,5)P2
Descriptor: ATP-sensitive inward rectifier potassium channel 12, DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, ...
Authors:Lee, S.-J, Ren, F, Yuan, P, Nichols, C.G.
Deposit date:2018-08-21
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.
J.Gen.Physiol., 152, 2020
6A6K
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BU of 6a6k by Molmil
Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000
Descriptor: 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma
Authors:Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J.
Deposit date:2018-06-28
Release date:2019-04-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
J. Med. Chem., 62, 2019
4WHK
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BU of 4whk by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S.
Deposit date:2014-09-23
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4WHL
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BU of 4whl by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K, Han, Y.H, Ahn, M.J, Lee, K.S.
Deposit date:2014-09-23
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
4ZRM
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BU of 4zrm by Molmil
Crystal Structure of UDP-Glucose 4-Epimerase (TM0509) from Hyperthermophilic Eubacterium Thermotoga maritima
Descriptor: GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase
Authors:Choi, J.M, Lee, D.W, Lee, S.H.
Deposit date:2015-05-12
Release date:2015-09-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structural basis of substrate promiscuity in UDP-hexose 4-epimerase from the hyperthermophilic Eubacterium Thermotoga maritima.
Arch.Biochem.Biophys., 585, 2015
4ZRN
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BU of 4zrn by Molmil
Crystal Structure of UDP-Glucose 4-Epimerase (TM0509) with UDP-glucose from Hyperthermophilic Eubacterium Thermotoga Maritima
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-glucose 4-epimerase, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Choi, J.M, Lee, D.W, Lee, S.H.
Deposit date:2015-05-12
Release date:2015-09-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis of substrate promiscuity in UDP-hexose 4-epimerase from the hyperthermophilic Eubacterium Thermotoga maritima
Arch.Biochem.Biophys., 585, 2015
6KNR
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BU of 6knr by Molmil
Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699
Descriptor: (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol, Estrogen-related receptor gamma
Authors:Yoon, H, Kim, J, Chin, J, Song, J, Cho, S.J.
Deposit date:2019-08-07
Release date:2020-08-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Eur.J.Med.Chem., 205, 2020
4WHH
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BU of 4whh by Molmil
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Descriptor: C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR, SULFATE ION, Serine/threonine-protein kinase PLK1
Authors:Bang, J.K.
Deposit date:2014-09-22
Release date:2014-12-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
J.Med.Chem., 58, 2015
6IFC
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BU of 6ifc by Molmil
Crystal structure of VapBC from Salmonella typhimurium
Descriptor: Antitoxin VapB, CALCIUM ION, tRNA(fMet)-specific endonuclease VapC
Authors:Park, D.W, Lee, B.J.
Deposit date:2018-09-19
Release date:2020-01-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+-dependent ribonuclease.
Faseb J., 34, 2020
6IFM
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BU of 6ifm by Molmil
Crystal structure of DNA bound VapBC from Salmonella typhimurium
Descriptor: Antitoxin VapB, DNA backward (27-MER), DNA forward (27-MER), ...
Authors:Park, D.W, Lee, B.J.
Deposit date:2018-09-20
Release date:2020-01-29
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+-dependent ribonuclease.
Faseb J., 34, 2020
5X3T
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BU of 5x3t by Molmil
VapBC from Mycobacterium tuberculosis
Descriptor: Antitoxin VapB26, MAGNESIUM ION, Ribonuclease VapC26
Authors:Kang, S.M, Kim, D.H, Yoon, H.J, Lee, B.J.
Deposit date:2017-02-07
Release date:2017-06-07
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides.
Nucleic Acids Res., 45, 2017
4W5M
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BU of 4w5m by Molmil
Prp peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PrP peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-08-18
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4W5Y
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BU of 4w5y by Molmil
Crystal structure of Prp pepttide
Descriptor: Prp peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-08-19
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.122 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4W5L
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BU of 4w5l by Molmil
Crystal structure of a prp peptide
Descriptor: PrP peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-08-18
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4WBV
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BU of 4wbv by Molmil
Crystal structure of a prion peptide
Descriptor: PrP peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-09-03
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
6L18
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BU of 6l18 by Molmil
XFEL structure of T4dCH D179N mutant complex with natively expressed dTMP
Descriptor: Deoxycytidylate 5-hydroxymethyltransferase, IODIDE ION, SODIUM ION, ...
Authors:Park, S.H, Song, H.K.
Deposit date:2019-09-27
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser.
Sci Rep, 9, 2019
4RSS
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BU of 4rss by Molmil
Crystal structure of tyrosine-protein kinase SYK with an inhibitor
Descriptor: 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK
Authors:Lee, B.I, Lee, S.J, Choi, J.-S.
Deposit date:2014-11-11
Release date:2015-10-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
4TUT
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BU of 4tut by Molmil
Structure of a Prion peptide
Descriptor: Prion peptide: GLY-GLY-TYR-MET-LEU-GLY
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-06-24
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4UBY
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BU of 4uby by Molmil
Crystal structure of a polymorphic beta1 peptide
Descriptor: prion peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-08-13
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4UBZ
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BU of 4ubz by Molmil
Crystal structure of a prion peptide
Descriptor: SODIUM ION, prion peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-08-13
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.001 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
4WBU
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BU of 4wbu by Molmil
prion peptide
Descriptor: PrP peptide
Authors:Yu, L, Lee, S.-J, Yee, V.
Deposit date:2014-09-03
Release date:2015-05-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations.
Biochemistry, 54, 2015
3U0R
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BU of 3u0r by Molmil
Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules
Descriptor: Apoptosis inhibitor 5
Authors:Han, B.G, Kim, K.H, Jeong, K.C, Cho, J.W, Noh, K.H, Kim, T.W, Yoon, H.J, Suh, S.W, Lee, S.H, Lee, B.I.
Deposit date:2011-09-29
Release date:2012-02-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.
J.Biol.Chem., 287, 2012
5B7Y
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BU of 5b7y by Molmil
Crystal Structure of Hyperthermophilic Thermotoga maritima L-Ketose-3-Epimerase with Co2+
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, COBALT (II) ION, ...
Authors:Cao, T.P, Shin, S.M, Lee, D.W, Lee, S.H.
Deposit date:2016-06-10
Release date:2017-03-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:TM0416, a Hyperthermophilic Promiscuous Nonphosphorylated Sugar Isomerase, Catalyzes Various C5and C6Epimerization Reactions
Appl. Environ. Microbiol., 83, 2017
5B7Z
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BU of 5b7z by Molmil
Crystal Structure of Hyperthermophilic Thermotoga maritima L-Ketose-3-Epimerase with Ni2+
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, NICKEL (II) ION, ...
Authors:Cao, T.P, Shin, S.M, Lee, D.W, Lee, S.H.
Deposit date:2016-06-10
Release date:2017-03-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:TM0416, a Hyperthermophilic Promiscuous Nonphosphorylated Sugar Isomerase, Catalyzes Various C5and C6Epimerization Reactions
Appl. Environ. Microbiol., 83, 2017

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數據於2024-06-12公開中

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