6VT4
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![BU of 6vt4 by Molmil](/molmil-images/mine/6vt4) | Naegleria gruberi RNA ligase R149A mutant apo | Descriptor: | RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTE
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![BU of 6vte by Molmil](/molmil-images/mine/6vte) | Naegleria gruberi RNA Ligase K170M mutant with AMP and Mn | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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5H8A
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![BU of 5h8a by Molmil](/molmil-images/mine/5h8a) | Mmi1 YTH domain | Descriptor: | YTH domain-containing protein mmi1 | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | Deposit date: | 2015-12-23 | Release date: | 2016-01-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. Rna, 22, 2016
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6VT8
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![BU of 6vt8 by Molmil](/molmil-images/mine/6vt8) | Naegleria gruberi RNA ligase E312A mutant with AMP and Mn | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT6
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![BU of 6vt6 by Molmil](/molmil-images/mine/6vt6) | Naegleria gruberi RNA ligase K170A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.969 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTG
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![BU of 6vtg by Molmil](/molmil-images/mine/6vtg) | Naegleria gruberi RNA ligase E227A mutant apo | Descriptor: | RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT9
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![BU of 6vt9 by Molmil](/molmil-images/mine/6vt9) | Naegleria gruberi RNA ligase E227A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT0
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![BU of 6vt0 by Molmil](/molmil-images/mine/6vt0) | Naegleria gruberi RNA ligase K170A mutant apo | Descriptor: | RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VTB
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![BU of 6vtb by Molmil](/molmil-images/mine/6vtb) | Naegleria gruberi RNA ligase K326A mutant with ATP and Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.547 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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6VT1
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![BU of 6vt1 by Molmil](/molmil-images/mine/6vt1) | Naegleria gruberi RNA ligase D172A mutant apo | Descriptor: | ADENOSINE MONOPHOSPHATE, RNA Ligase | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | Deposit date: | 2020-02-12 | Release date: | 2020-04-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.381 Å) | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation. Nucleic Acids Res., 48, 2020
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5COV
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![BU of 5cov by Molmil](/molmil-images/mine/5cov) | |
5COU
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![BU of 5cou by Molmil](/molmil-images/mine/5cou) | |
4YKL
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![BU of 4ykl by Molmil](/molmil-images/mine/4ykl) | Hnt3 in complex with DNA and guanosine | Descriptor: | Aprataxin-like protein, CHLORIDE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | Deposit date: | 2015-03-04 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Res., 43, 2015
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5E7P
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![BU of 5e7p by Molmil](/molmil-images/mine/5e7p) | Crystal Structure of MSMEG_0858 (Uniprot A0QQS4), a AAA ATPase. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein Cdc48, GLYCEROL, ... | Authors: | Unciulac-Carp, M, Smith, P, Shuman, S. | Deposit date: | 2015-10-12 | Release date: | 2016-08-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858). J.Bacteriol., 198, 2016
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1VS0
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![BU of 1vs0 by Molmil](/molmil-images/mine/1vs0) | Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ... | Authors: | Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2006-01-27 | Release date: | 2006-02-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D. J.Biol.Chem., 281, 2006
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5COT
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1I9T
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![BU of 1i9t by Molmil](/molmil-images/mine/1i9t) | CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME | Descriptor: | CACODYLATE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | Authors: | Changela, A, Ho, C.K, Martins, A, Shuman, S, Mondragon, A. | Deposit date: | 2001-03-20 | Release date: | 2001-05-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J., 20, 2001
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1I9S
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![BU of 1i9s by Molmil](/molmil-images/mine/1i9s) | CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME | Descriptor: | CACODYLATE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | Authors: | Changela, A, Ho, C.K, Martins, A, Shuman, S, Mondragon, A. | Deposit date: | 2001-03-20 | Release date: | 2001-05-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J., 20, 2001
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1FVI
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![BU of 1fvi by Molmil](/molmil-images/mine/1fvi) | CRYSTAL STRUCTURE OF CHLORELLA VIRUS DNA LIGASE-ADENYLATE | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORELLA VIRUS DNA LIGASE-ADENYLATE, SULFATE ION | Authors: | Odell, M, Sriskanda, V, Shuman, S, Nikolov, D.B. | Deposit date: | 2000-09-20 | Release date: | 2000-11-22 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining. Mol.Cell, 6, 2000
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1Z3C
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![BU of 1z3c by Molmil](/molmil-images/mine/1z3c) | Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed with AzoAdoMet | Descriptor: | S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE, mRNA CAPPING ENZYME | Authors: | Hausmann, S, Zhang, S, Fabrega, C, Schneller, S.W, Lima, C.D, Shuman, S. | Deposit date: | 2005-03-11 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J.Biol.Chem., 280, 2005
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1N82
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![BU of 1n82 by Molmil](/molmil-images/mine/1n82) | The high-resolution crystal structure of IXT6, a thermophilic, intracellular xylanase from G. stearothermophilus | Descriptor: | GLYCEROL, SODIUM ION, intra-cellular xylanase | Authors: | Solomon, V, Teplitsky, A, Golan, G, Gilboa, R, Reiland, V, Shulami, S, Moryles, S, Zolotnitsky, G, Shoham, Y, Shoham, G. | Deposit date: | 2002-11-19 | Release date: | 2003-11-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The high-resolution crystal structure of IXT6,
a thermophilic, intracellular xylanase from G. stearothermophilus To be Published
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7KW9
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![BU of 7kw9 by Molmil](/molmil-images/mine/7kw9) | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis in complex with NAD+ | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, tRNA 2'-phosphotransferase | Authors: | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | Deposit date: | 2020-11-30 | Release date: | 2021-10-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity. Nucleic Acids Res., 49, 2021
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7KW8
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![BU of 7kw8 by Molmil](/molmil-images/mine/7kw8) | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis | Descriptor: | tRNA 2'-phosphotransferase | Authors: | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | Deposit date: | 2020-11-30 | Release date: | 2021-10-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity. Nucleic Acids Res., 49, 2021
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1RI5
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![BU of 1ri5 by Molmil](/molmil-images/mine/1ri5) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1RI4
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![BU of 1ri4 by Molmil](/molmil-images/mine/1ri4) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | S-ADENOSYLMETHIONINE, mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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