7WK0
 
 | | Local refine of Omicron spike bitrimer with 6m6 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-08 | | Release date: | 2022-07-13 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding.
Cell Res., 32, 2022
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7WJY
 | | Omicron spike trimer with 6m6 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-08 | | Release date: | 2022-07-13 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding.
Cell Res., 32, 2022
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7WJZ
 | | Omicron Spike bitrimer with 6m6 antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-08 | | Release date: | 2022-07-13 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding.
Cell Res., 32, 2022
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7VGG
 | | Cryo-EM structure of Ultraviolet-B activated UVR8 in complex with COP1 | | Descriptor: | E3 ubiquitin-protein ligase COP1, Ultraviolet-B receptor UVR8 | | Authors: | Wang, Y.D, Wang, L.X, Guan, Z.Y, Yin, P. | | Deposit date: | 2021-09-16 | | Release date: | 2022-05-04 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insight into UV-B-activated UVR8 bound to COP1.
Sci Adv, 8, 2022
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7WOP
 | | The local refined map of Omicron spike with bispecific antibody FD01 | | Descriptor: | 16L9, GW01, Spike protein S1 | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOR
 | | The state 2 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, GW01 Fv, ... | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOS
 | | The state 3 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, GW01 Fv, ... | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOV
 | | The state 5 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, GW01 Fv, ... | | Authors: | Zhang, X, Zhan, W.Q, Sun, L, Chen, Z.G. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOW
 | | The state 6 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, GW01 Fv, Spike glycoprotein | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (6.11 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOU
 | | The state 4 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, GW01 Fv, ... | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7WOQ
 | | The state 1 of Omicron Spike with bispecific antibody FD01 | | Descriptor: | 16L9 Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Zhang, X, Zhan, W.Q, Chen, Z.G, Sun, L. | | Deposit date: | 2022-01-22 | | Release date: | 2022-11-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies
Cell Discov, 8, 2022
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7YMK
 | | Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with an Covalent Selective Estrogen Receptor Degrader 29c and GRIP Peptide | | Descriptor: | DI(HYDROXYETHYL)ETHER, Estrogen receptor, Grip peptide, ... | | Authors: | Min, J, Hu, H.B, Yang, Y, Dong, C.E, Zhou, H.B, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2022-07-28 | | Release date: | 2023-05-31 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer.
Acta Pharm Sin B, 13, 2023
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8KBZ
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3NCU
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5XYX
 | | The structure of p38 alpha in complex with a triazol inhibitor | | Descriptor: | Mitogen-activated protein kinase 14, N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine | | Authors: | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. | | Deposit date: | 2017-07-11 | | Release date: | 2018-01-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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5XYY
 | | The structure of p38 alpha in complex with a triazol inhibitor | | Descriptor: | 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol, Mitogen-activated protein kinase 14 | | Authors: | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. | | Deposit date: | 2017-07-11 | | Release date: | 2018-01-17 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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5XYZ
 | | The structure of human BTK kinase domain in complex with a covalent inhibitor | | Descriptor: | N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide, Tyrosine-protein kinase BTK | | Authors: | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Xie, Y.T, Li, L, Qi, X.B, Huang, N. | | Deposit date: | 2017-07-11 | | Release date: | 2018-05-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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5XIW
 | | Crystal structure of T2R-TTL-Colchicine complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | | Deposit date: | 2017-04-27 | | Release date: | 2018-04-18 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
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5XP3
 | | Crystal structure of apo T2R-TTL | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | | Deposit date: | 2017-05-31 | | Release date: | 2017-10-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
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7W5E
 | | Oxidase ChaP D49L mutant | | Descriptor: | ChaP, FE (III) ION | | Authors: | Wang, Y, Zheng, W, Meng, Z, Jin, Y, Zhu, J, Tan, R. | | Deposit date: | 2021-11-30 | | Release date: | 2022-10-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution.
Angew.Chem.Int.Ed.Engl., 61, 2022
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5EKJ
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5EKH
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5EKM
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6AE8
 | | Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement | | Descriptor: | BICINE, Histone H2A.Z-specific chaperone CHZ1, Histone H2B.1,Histone H2A.Z | | Authors: | Wang, Y.Y, Shan, S, Zhou, Z. | | Deposit date: | 2018-08-03 | | Release date: | 2019-04-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.
Plos Biol., 17, 2019
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8WYS
 | | Local map of human CD5L bound to IgM-Fc/J | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Wang, Y.X, Su, C, Xiao, J.Y. | | Deposit date: | 2023-10-31 | | Release date: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | CD5L associates with IgM via the J chain.
Nat Commun, 15, 2024
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