6K9C
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![BU of 6k9c by Molmil](/molmil-images/mine/6k9c) | The apo structure of NrS-1 C terminal region (305-718) | Descriptor: | MERCURY (II) ION, Primase, SULFATE ION | Authors: | Chen, X, Gan, J. | Deposit date: | 2019-06-14 | Release date: | 2020-04-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.406 Å) | Cite: | Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase. Nucleic Acids Res., 48, 2020
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6K9E
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6LRB
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![BU of 6lrb by Molmil](/molmil-images/mine/6lrb) | |
8GZJ
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![BU of 8gzj by Molmil](/molmil-images/mine/8gzj) | |
8GZL
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8GZM
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![BU of 8gzm by Molmil](/molmil-images/mine/8gzm) | |
8GZK
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7Y56
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![BU of 7y56 by Molmil](/molmil-images/mine/7y56) | |
7Y57
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7Y67
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![BU of 7y67 by Molmil](/molmil-images/mine/7y67) | Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein | Descriptor: | C089 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | Deposit date: | 2022-06-18 | Release date: | 2023-03-01 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y65
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![BU of 7y65 by Molmil](/molmil-images/mine/7y65) | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | Descriptor: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | Deposit date: | 2022-06-18 | Release date: | 2023-03-01 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y64
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![BU of 7y64 by Molmil](/molmil-images/mine/7y64) | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | Descriptor: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | Deposit date: | 2022-06-18 | Release date: | 2023-03-01 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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7Y66
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![BU of 7y66 by Molmil](/molmil-images/mine/7y66) | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | Descriptor: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | Deposit date: | 2022-06-18 | Release date: | 2023-03-01 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of activation and biased signaling in complement receptor C5aR1. Cell Res., 33, 2023
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3K5D
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![BU of 3k5d by Molmil](/molmil-images/mine/3k5d) | Crystal Structure of BACE-1 in complex with AHM178 | Descriptor: | Beta-secretase 1, N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide | Authors: | Rondeau, J.-M. | Deposit date: | 2009-10-07 | Release date: | 2010-05-05 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3K5G
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![BU of 3k5g by Molmil](/molmil-images/mine/3k5g) | Human bace-1 complex with bjc060 | Descriptor: | (1R,3S)-N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(1-methylethyl)benzyl]amino}propyl]-3-[1-methyl-1-(2-oxopiperidin-1-yl)ethyl]cyclohexanecarboxamide, Beta-secretase 1 | Authors: | Rondeau, J.-M. | Deposit date: | 2009-10-07 | Release date: | 2010-05-05 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3K5F
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![BU of 3k5f by Molmil](/molmil-images/mine/3k5f) | Human BACE-1 COMPLEX WITH AYH011 | Descriptor: | (1R,3S)-3-[1-(acetylamino)-1-methylethyl]-N-[(1S,2S,4R)-1-benzyl-5-(butylamino)-2-hydroxy-4-methyl-5-oxopentyl]cyclohexanecarboxamide, Beta-secretase 1 | Authors: | Rondeau, J.-M. | Deposit date: | 2009-10-07 | Release date: | 2010-05-05 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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5GUT
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![BU of 5gut by Molmil](/molmil-images/mine/5gut) | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Chen, S.J, Ye, F. | Deposit date: | 2016-08-31 | Release date: | 2017-09-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
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5GUV
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![BU of 5guv by Molmil](/molmil-images/mine/5guv) | The crystal structure of mouse DNMT1 (731-1602) mutant - R1279D | Descriptor: | DNA (cytosine-5)-methyltransferase 1, ZINC ION | Authors: | Ye, F, Chen, S.J. | Deposit date: | 2016-08-31 | Release date: | 2017-08-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.078 Å) | Cite: | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
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2GD3
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![BU of 2gd3 by Molmil](/molmil-images/mine/2gd3) | NMR structure of S14G-humanin in 30% TFE solution | Descriptor: | Humanin | Authors: | Benaki, D, Zikos, C, Evangelou, A, Livaniou, E, Vlassi, M, Mikros, E, Pelecanou, M. | Deposit date: | 2006-03-15 | Release date: | 2006-09-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. Biochem.Biophys.Res.Commun., 349, 2006
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6KHY
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![BU of 6khy by Molmil](/molmil-images/mine/6khy) | The crystal structure of AsfvAP:AG | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (AGCGTCACCGACGAGGC), DNA(AGCGTCACCGACGAGG), ... | Authors: | Chen, Y.Q, Gan, J.H. | Deposit date: | 2019-07-16 | Release date: | 2020-06-03 | Method: | X-RAY DIFFRACTION (3.008 Å) | Cite: | A unique DNA-binding mode of African swine fever virus AP endonuclease. Cell Discov, 6, 2020
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6KI3
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![BU of 6ki3 by Molmil](/molmil-images/mine/6ki3) | The crystal structure of AsfvAP:dF commplex | Descriptor: | DNA (5'-D(*CP*CP*TP*CP*GP*TP*CP*GP*GP*GP*GP*AP*CP*GP*CP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*GP*CP*GP*TP*CP*C)-3'), DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*AP*G)-3'), ... | Authors: | Chen, Y, Gan, J. | Deposit date: | 2019-07-17 | Release date: | 2020-05-27 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | A unique DNA-binding mode of African swine fever virus AP endonuclease. Cell Discov, 6, 2020
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3V53
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![BU of 3v53 by Molmil](/molmil-images/mine/3v53) | Crystal structure of human RBM25 | Descriptor: | RNA-binding protein 25 | Authors: | Gong, D.S. | Deposit date: | 2011-12-16 | Release date: | 2012-12-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region Biochem.J., 450, 2013
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7W2Z
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![BU of 7w2z by Molmil](/molmil-images/mine/7w2z) | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex | Descriptor: | Appetite-regulating hormone, CHOLESTEROL, Growth hormone secretagogue receptor type 1, ... | Authors: | Qin, J, Ming, Q, Ji, S, Mao, C, Shen, D, Zhang, Y. | Deposit date: | 2021-11-24 | Release date: | 2022-01-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nat Commun, 13, 2022
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7C43
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7C4C
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