Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5W0Q
DownloadVisualize
BU of 5w0q by Molmil
CREBBP Bromodomain in complex with Cpd17 (N,2,7-trimethyl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide)
Descriptor: (2R)-N,2,7-trimethyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, CREB-binding protein, SULFATE ION
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0F
DownloadVisualize
BU of 5w0f by Molmil
CREBBP Bromodomain in complex with Cpd3 ((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Descriptor: 1-{3-[6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
5W0L
DownloadVisualize
BU of 5w0l by Molmil
CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Descriptor: 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein
Authors:Murray, J.M.
Deposit date:2017-05-31
Release date:2018-03-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
3P3E
DownloadVisualize
BU of 3p3e by Molmil
Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex
Descriptor: N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, NITRATE ION, SODIUM ION, ...
Authors:Lee, C.-J, Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
3P3G
DownloadVisualize
BU of 3p3g by Molmil
Crystal Structure of the Escherichia coli LpxC/LPC-009 complex
Descriptor: 4-ethynyl-N-[(1S,2R)-2-hydroxy-1-(oxocarbamoyl)propyl]benzamide, DIMETHYL SULFOXIDE, N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, ...
Authors:Lee, C.-J, Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
8UDG
DownloadVisualize
BU of 8udg by Molmil
S1V2-72 Fab bound to EHA2 from influenza B/Malaysia/2506/2004
Descriptor: Hemagglutinin, S1V2-72 heavy chain, S1V2-72 light chain
Authors:Finney, J, Kong, S, Walsh Jr, R.M, Harrison, S.C, Kelsoe, G.
Deposit date:2023-09-28
Release date:2023-11-15
Last modified:2024-01-10
Method:ELECTRON MICROSCOPY (4.98 Å)
Cite:Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin.
Proc.Natl.Acad.Sci.USA, 121, 2024
3P3C
DownloadVisualize
BU of 3p3c by Molmil
Crystal Structure of the Aquifex aeolicus LpxC/LPC-009 complex
Descriptor: N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, PHOSPHATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ...
Authors:Lee, C.-J, Zhou, P.
Deposit date:2010-10-04
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
Chem.Biol., 18, 2011
5W0E
DownloadVisualize
BU of 5w0e by Molmil
CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)
Descriptor: 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, CREB-binding protein
Authors:Murray, J.M.
Deposit date:2017-05-30
Release date:2018-02-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.
J. Med. Chem., 60, 2017
4XX4
DownloadVisualize
BU of 4xx4 by Molmil
Renin in complex with (4S)-4-isopropyl-4-methyl-6-oxo-1-(3-(2-oxo-4-phenylpyrrolidin-1-yl)benzyl)tetrahydropyrimidin-2(1H)-iminium
Descriptor: (2Z,6S)-2-imino-6-methyl-3-{3-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]benzyl}-6-(propan-2-yl)tetrahydropyrimidin-4(1H)-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin
Authors:Orth, P.
Deposit date:2015-01-29
Release date:2015-02-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg. Med. Chem. Lett., 25, 2015
4XX3
DownloadVisualize
BU of 4xx3 by Molmil
Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide, Renin
Authors:Orth, P.
Deposit date:2015-01-29
Release date:2015-02-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg. Med. Chem. Lett., 25, 2015
5CP7
DownloadVisualize
BU of 5cp7 by Molmil
Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides
Descriptor: Heavy Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7, Light Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7
Authors:Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X.
Deposit date:2015-07-21
Release date:2015-08-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity.
Anal. Chem., 91, 2019
5CP3
DownloadVisualize
BU of 5cp3 by Molmil
Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides in Complex with Sulfathiazole
Descriptor: 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, CALCIUM ION, GLYCEROL, ...
Authors:Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X.
Deposit date:2015-07-21
Release date:2015-08-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity.
Anal. Chem., 91, 2019
1FPR
DownloadVisualize
BU of 1fpr by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.
Descriptor: PEPTIDE PY469, PROTEIN-TYROSINE PHOSPHATASE 1C
Authors:Yang, J, Cheng, Z, Niu, Z, Zhao, Z.J, Zhou, G.W.
Deposit date:2000-08-31
Release date:2001-03-07
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
4JNM
DownloadVisualize
BU of 4jnm by Molmil
Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
Descriptor: 1,2-ETHANEDIOL, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, Nicotinamide phosphoribosyltransferase, ...
Authors:Gunzner-Toste, J, Zhao, G, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Fu, B, Han, B, Ho, Y, Kley, N, Liederer, B, Lin, J, Mukadam, S, O'Brien, T, Reynolds, D.J, Sharma, G, Skelton, N, Smith, C.C, Oh, A, Wang, W, Wang, Z, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X, Bair, K.W, Dragovich, P.S.
Deposit date:2013-03-15
Release date:2013-05-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg.Med.Chem.Lett., 23, 2013
8E22
DownloadVisualize
BU of 8e22 by Molmil
VPS37A_21-148
Descriptor: Vacuolar protein sorting-associated protein 37A
Authors:Tian, F, Ye, Y.S.
Deposit date:2022-08-12
Release date:2023-08-09
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure.
Commun Biol, 7, 2024
6U7J
DownloadVisualize
BU of 6u7j by Molmil
Uncultured Clostridium sp. Beta-glucuronidase
Descriptor: Beta-glucuronidase, CALCIUM ION
Authors:Ervin, S.M, Redinbo, M.R.
Deposit date:2019-09-03
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.
J.Biol.Chem., 294, 2019
6U7I
DownloadVisualize
BU of 6u7i by Molmil
Faecalibacterium prausnitzii Beta-glucuronidase
Descriptor: Beta-glucuronidase
Authors:Ervin, S.M, Redinbo, M.R.
Deposit date:2019-09-03
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens.
J.Biol.Chem., 294, 2019
8IPX
DownloadVisualize
BU of 8ipx by Molmil
human nuclear pre-60S ribosomal particle - State C'
Descriptor: 28S rRNA, 5.8S rRNA, 5S RNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-15
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8IPY
DownloadVisualize
BU of 8ipy by Molmil
human nuclear pre-60S ribosomal particle - State D'
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-15
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8INF
DownloadVisualize
BU of 8inf by Molmil
human nuclear pre-60S ribosomal particle - State F'
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8INK
DownloadVisualize
BU of 8ink by Molmil
human nuclear pre-60S ribosomal particle - State D
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-10
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8INE
DownloadVisualize
BU of 8ine by Molmil
human nuclear pre-60S ribosomal particle - State G'
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-09
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8IDY
DownloadVisualize
BU of 8idy by Molmil
human nuclear pre-60S ribosomal particle - State F
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-02-14
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8IE3
DownloadVisualize
BU of 8ie3 by Molmil
human nuclear pre-60S ribosomal particle - State E
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-02-15
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023
8IPD
DownloadVisualize
BU of 8ipd by Molmil
human nuclear pre-60S ribosomal particle - State C
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Zhang, Y, Gao, N.
Deposit date:2023-03-14
Release date:2023-08-09
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
Cell Res., 33, 2023

222624

數據於2024-07-17公開中

PDB statisticsPDBj update infoContact PDBjnumon