2B6P
| X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state | Descriptor: | Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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2B6O
| Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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5IE1
| Crystal structure of BACE1 in complex with 3-(2-amino-6-(o-tolyl)quinolin-3-yl)-N-(3,3-dimethylbutyl)propanamide | Descriptor: | 3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-(3,3-dimethylbutyl)propanamide, Beta-secretase 1, GLYCEROL, ... | Authors: | Jordan, J.B, Whittington, D.A, Bartberger, M.D, Sickmier, E.A, Chen, K, Cheng, Y, Judd, T. | Deposit date: | 2016-02-24 | Release date: | 2016-03-30 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of beta-Secretase. J.Med.Chem., 59, 2016
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8CXB
| Human PA28-20S (PA28-4a3b) | Descriptor: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | Authors: | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | Deposit date: | 2022-05-20 | Release date: | 2022-11-02 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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1SOR
| Aquaporin-0 membrane junctions reveal the structure of a closed water pore | Descriptor: | Aquaporin-0 | Authors: | Gonen, T, Sliz, P, Kistler, J, Cheng, Y, Walz, T. | Deposit date: | 2004-03-15 | Release date: | 2004-05-11 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | Cite: | Aquaporin-0 membrane junctions reveal the structure of a closed water pore Nature, 429, 2004
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8CX0
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX2
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CX1
| Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | Descriptor: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | Authors: | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-15 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Nature, 615, 2023
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8CXO
| Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment | Descriptor: | CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera | Authors: | Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y. | Deposit date: | 2022-05-22 | Release date: | 2022-08-03 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun, 13, 2022
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6UTG
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2ASL
| oxoG-modified Postinsertion Binary Complex | Descriptor: | 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', CALCIUM ION, ... | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 2005-08-23 | Release date: | 2006-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion Plos Biol., 4, 2006
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3C91
| Thermoplasma acidophilum 20S proteasome with an open gate | Descriptor: | Proteasome subunit alpha, Proteasome subunit beta | Authors: | Rabl, J, Smith, D.M, Yu, Y, Chang, S.C, Goldberg, A.L, Cheng, Y. | Deposit date: | 2008-02-14 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol.Cell, 30, 2008
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2ASD
| oxoG-modified Insertion Ternary Complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 2005-08-23 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion Plos Biol., 4, 2006
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2AU0
| Unmodified preinsertion binary complex | Descriptor: | 5'-D(*CP*TP*AP*AP*CP*G*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', CALCIUM ION, ... | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 2005-08-26 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion Plos Biol., 4, 2006
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6DJP
| Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 68 heavy chain Fab, ... | Authors: | Cormier, A, Campbell, M.G, Nishimura, S.L, Cheng, Y. | Deposit date: | 2018-05-25 | Release date: | 2018-07-25 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension. Nat. Struct. Mol. Biol., 25, 2018
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3C92
| Thermoplasma acidophilum 20S proteasome with a closed gate | Descriptor: | Proteasome subunit alpha, Proteasome subunit beta | Authors: | Rabl, J, Smith, D.M, Yu, Y, Chang, S.C, Goldberg, A.L, Cheng, Y. | Deposit date: | 2008-02-14 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol.Cell, 30, 2008
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6E1M
| Structure of AtTPC1(DDE) reconstituted in saposin A | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CALCIUM ION, PALMITIC ACID, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1P
| Structure of AtTPC1(DDE) in state 2 | Descriptor: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1 | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1N
| Structure of AtTPC1(DDE) in state 1 | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CALCIUM ION, PALMITIC ACID, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1K
| Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab | Descriptor: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2ASJ
| oxoG-modified Preinsertion Binary Complex | Descriptor: | 5'-D(*CP*TP*AP*AP*CP*(8OG)*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', CALCIUM ION, ... | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 2005-08-23 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion Plos Biol., 4, 2006
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2ATL
| Unmodified Insertion Ternary Complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*T*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | Deposit date: | 2005-08-25 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion Plos Biol., 4, 2006
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2ME4
| HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle | Descriptor: | Envelope glycoprotein gp160 | Authors: | Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W. | Deposit date: | 2013-09-20 | Release date: | 2013-10-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41. J.Mol.Biol., 426, 2014
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2ME1
| HIV-1 gp41 clade B double alanine mutant Membrane Proximal External Region peptide in DPC micelle | Descriptor: | Gp41 | Authors: | Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W. | Deposit date: | 2013-09-20 | Release date: | 2013-10-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41. J.Mol.Biol., 426, 2014
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2ME2
| HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle | Descriptor: | Envelope glycoprotein gp160 | Authors: | Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W. | Deposit date: | 2013-09-20 | Release date: | 2013-10-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41. J.Mol.Biol., 426, 2014
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