6P48
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1 | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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8TAG
| TMEM16F, with Calcium and PIP2, no inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Cheng, Y. | Deposit date: | 2023-06-27 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8TAL
| TMEM16F, with Calcium and PIP2, no inhibitor, Cl1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | Authors: | Wu, H, Feng, S, Cheng, Y. | Deposit date: | 2023-06-27 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8SUR
| TMEM16F bound with Niclosamide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... | Authors: | Feng, S, Cheng, Y. | Deposit date: | 2023-05-13 | Release date: | 2023-09-06 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8TAI
| TMEM16F, with Calcium and PIP2, no inhibitor, Cl2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | Authors: | Wu, H, Feng, S, Cheng, Y. | Deposit date: | 2023-06-27 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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8SUN
| TMEM16F 1PBC | Descriptor: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, ... | Authors: | Wu, H, Feng, S, Cheng, Y. | Deposit date: | 2023-05-12 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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5VKQ
| Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, No mechanoreceptor potential C isoform L | Authors: | Jin, P, Bulkley, D, Guo, Y, Zhang, W, Guo, Z, Huynh, W, Wu, S, Meltzer, S, Chen, T, Jan, L.Y, Jan, Y.-N, Cheng, Y. | Deposit date: | 2017-04-22 | Release date: | 2017-06-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature, 547, 2017
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1Q57
| The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 | Descriptor: | DNA primase/helicase | Authors: | Toth, E.A, Li, Y, Sawaya, M.R, Cheng, Y, Ellenberger, T. | Deposit date: | 2003-08-06 | Release date: | 2003-11-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 Mol.Cell, 12, 2003
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7RMG
| Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | Deposit date: | 2021-07-27 | Release date: | 2021-11-03 | Last modified: | 2022-01-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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7RMH
| Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | Deposit date: | 2021-07-27 | Release date: | 2021-11-03 | Last modified: | 2022-01-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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7RMI
| SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | Deposit date: | 2021-07-27 | Release date: | 2021-11-03 | Last modified: | 2022-01-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18, 2022
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2B6P
| X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state | Descriptor: | Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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2B6O
| Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) at 1.9A resolution, in a closed pore state | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Lens fiber major intrinsic protein | Authors: | Gonen, T, Cheng, Y, Sliz, P, Hiroaki, Y, Fujiyoshi, Y, Harrison, S.C, Walz, T. | Deposit date: | 2005-10-03 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | Cite: | Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature, 438, 2005
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1XI4
| Clathrin D6 Coat | Descriptor: | Clathrin heavy chain, Clathrin light chain A | Authors: | Fotin, A, Cheng, Y, Sliz, P, Grigorieff, N, Harrison, S.C, Kirchhausen, T, Walz, T. | Deposit date: | 2004-09-21 | Release date: | 2004-11-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Molecular model for a complete clathrin lattice from electron cryomicroscopy Nature, 432, 2004
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1XI5
| Clathrin D6 coat with auxilin J-domain | Descriptor: | Auxilin J-domain, Clathrin heavy chain | Authors: | Fotin, A, Cheng, Y, Grigorieff, N, Walz, T, Harrison, S.C, Kirchhausen, T. | Deposit date: | 2004-09-21 | Release date: | 2004-11-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (12 Å) | Cite: | Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating Nature, 432, 2004
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7STQ
| Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with chlorimuron-ethyl | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]SULFONYL]BENZOIC ACID ETHYL ESTER, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | Authors: | Guddat, L.W, Cheng, Y. | Deposit date: | 2021-11-15 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nat Commun, 13, 2022
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7U1D
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7U1U
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7U25
| Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with bispyribac-sodium | Descriptor: | 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | Authors: | Guddat, L.W, Cheng, Y. | Deposit date: | 2022-02-23 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nat Commun, 13, 2022
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7TZZ
| Crystal structure of arabidopsis thaliana acetohydroxyacid synthase P197T mutant in complex with bispyribac-sodium | Descriptor: | 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid, 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Guddat, L.W, Cheng, Y. | Deposit date: | 2022-02-16 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nat Commun, 13, 2022
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4KWE
| GDP-bound, double-stranded, curved FtsZ protofilament structure | Descriptor: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | Authors: | Li, Y, Hsin, J, Zhao, L, Cheng, Y, Shang, W, Huang, K.C, Wang, H.W, Ye, S. | Deposit date: | 2013-05-23 | Release date: | 2013-07-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation Science, 341, 2013
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6O77
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, calcium-bound state | Descriptor: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Diver, M.M, Cheng, Y, Julius, D. | Deposit date: | 2019-03-07 | Release date: | 2019-09-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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6O72
| Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, TC-I 2014-bound state | Descriptor: | (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Diver, M.M, Cheng, Y, Julius, D. | Deposit date: | 2019-03-07 | Release date: | 2019-09-18 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into TRPM8 inhibition and desensitization. Science, 365, 2019
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7M71
| SARS-CoV-2 Spike:5A6 Fab complex I focused refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 5A6 Fab heavy chain, Antibody 5A6 Fab light chain, ... | Authors: | Asarnow, D, Cheng, Y. | Deposit date: | 2021-03-26 | Release date: | 2021-05-26 | Last modified: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell, 184, 2021
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7M7B
| SARS-CoV-2 Spike:Fab 3D11 complex focused refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 3D11 heavy chain, Antibody Fab 3D11 light chain, ... | Authors: | Asarnow, D, Cheng, Y. | Deposit date: | 2021-03-27 | Release date: | 2021-05-26 | Last modified: | 2021-06-23 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia. Cell, 184, 2021
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