2QFE
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![BU of 2qfe by Molmil](/molmil-images/mine/2qfe) | Distal C2-Like Domain of Human Calpain-7 | Descriptor: | BROMIDE ION, Calpain-7 | Authors: | Walker, J.R, Cuerrier, D, Ravulapalli, R, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S. | Deposit date: | 2007-06-27 | Release date: | 2007-07-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of the C2 Domain of Human Calpain-7 To be Published
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2OME
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![BU of 2ome by Molmil](/molmil-images/mine/2ome) | Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H) | Descriptor: | C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Pilka, E.S, Guo, K, Rojkova, A, Debreczeni, J.E, Kavanagh, K.L, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-01-22 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H) To be Published
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2Q9V
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![BU of 2q9v by Molmil](/molmil-images/mine/2q9v) | Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate kinase | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Authors: | Pilka, E.S, Hozjan, V, Kavanagh, K.L, Papagrigoriou, E, Cooper, C, Elkins, J.M, Doyle, D.A, von Delft, F, Sundstrom, M, Arrowsmith, C.A, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-14 | Release date: | 2007-06-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate kinase. To be Published
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2QNR
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![BU of 2qnr by Molmil](/molmil-images/mine/2qnr) | Human septin 2 in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Septin-2, UNKNOWN ATOM OR ION | Authors: | Rabeh, W.M, Nedyalkova, L, Tempel, W, Landry, R, Crombet, L, Kozieradzki, I, Senisterra, G, Vedadi, M, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-19 | Release date: | 2007-07-31 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Human septin 2 in complex with GDP. To be Published
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2HLZ
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![BU of 2hlz by Molmil](/molmil-images/mine/2hlz) | Crystal Structure of human ketohexokinase | Descriptor: | Ketohexokinase, UNKNOWN ATOM OR ION | Authors: | Rabeh, W.M, Tempel, W, Nedyalkova, L, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-07-10 | Release date: | 2006-08-08 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of human ketohexokinase (CASP Target) To be Published
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2QQ5
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![BU of 2qq5 by Molmil](/molmil-images/mine/2qq5) | Crystal structure of human SDR family member 1 | Descriptor: | Dehydrogenase/reductase SDR family member 1 | Authors: | Pilka, E.S, Hozjan, V, Ugochukwu, E, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-26 | Release date: | 2007-08-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human SDR family member 1. TO BE PUBLISHED
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2R37
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![BU of 2r37 by Molmil](/molmil-images/mine/2r37) | Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant) | Descriptor: | CHLORIDE ION, Glutathione peroxidase 3, SODIUM ION | Authors: | Pilka, E.S, Guo, K, Gileadi, O, Rojkowa, A, von Delft, F, Pike, A.C.W, Kavanagh, K.L, Johannson, C, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-08-29 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant). TO BE PUBLISHED
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2QIS
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![BU of 2qis by Molmil](/molmil-images/mine/2qis) | Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate | Descriptor: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthetase, MAGNESIUM ION | Authors: | Kavanagh, K.L, Dunford, J.E, Hozjan, V, Evdokimov, A, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-05 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate. To be Published
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2QKQ
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![BU of 2qkq by Molmil](/molmil-images/mine/2qkq) | Structure of the SAM Domain of Human Ephrin Type-B Receptor 4 | Descriptor: | CHLORIDE ION, Ephrin type-B receptor 4 | Authors: | Walker, J.R, Cuerrier, D, Butler-Cole, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-11 | Release date: | 2007-07-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | SAM Domain of Human Ephrin Type-B Receptor 4 (EPHB4) TO BE PUBLISHED
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2P02
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![BU of 2p02 by Molmil](/molmil-images/mine/2p02) | Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2 | Descriptor: | CHLORIDE ION, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthetase isoform type-2 | Authors: | Papagrigoriou, E, Shafqat, N, Rojkova, A, Niessen, F.H, Kavanagh, K.L, von Delft, F, Gorrec, F, Ugochukwu, E, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-02-28 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2 To be Published
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2P57
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![BU of 2p57 by Molmil](/molmil-images/mine/2p57) | GAP domain of ZNF289, an ID1-regulated zinc finger protein | Descriptor: | GTPase-activating protein ZNF289, UNKNOWN ATOM OR ION, ZINC ION | Authors: | Tong, Y, Dimov, S, Shen, L, Zhu, H, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-03-14 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | GAP domain of ZNF289, an ID1-regulated zinc finger protein To be Published
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2QW4
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![BU of 2qw4 by Molmil](/molmil-images/mine/2qw4) | Human NR4A1 ligand-binding domain | Descriptor: | Orphan nuclear receptor NR4A1 | Authors: | Min, J.R, Schuetz, A, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-08-09 | Release date: | 2007-08-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Human Nr4A1 Ligand-Binding Domain To be Published
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2QQ8
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![BU of 2qq8 by Molmil](/molmil-images/mine/2qq8) | Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14 | Descriptor: | TBC1 domain family member 14, UNKNOWN ATOM OR ION | Authors: | Tong, Y, Tempel, W, Dimov, S, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-26 | Release date: | 2007-08-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14. To be Published
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2R4H
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![BU of 2r4h by Molmil](/molmil-images/mine/2r4h) | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase | Descriptor: | HISTIDINE, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | Authors: | Ugochukwu, E, Pilka, E.S, Hozjan, V, Kavanagh, K.L, Cooper, C, Pike, A.C.W, Elkins, J.M, Doyle, D.A, von Delft, F, Sundstrom, M, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2007-08-31 | Release date: | 2007-10-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase. To be Published
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2REI
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![BU of 2rei by Molmil](/molmil-images/mine/2rei) | Kinase domain of human ephrin type-A receptor 7 (Epha7) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Ephrin type-A receptor 7 | Authors: | Walker, J.R, Cuerrier, D, Butler-Cole, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2007-09-26 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Kinase Domain of Human Ephrin Type-A Receptor 7 (Epha7). To be Published
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2XAE
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![BU of 2xae by Molmil](/molmil-images/mine/2xae) | Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid | Descriptor: | (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | Authors: | Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Tkocz, K, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F. | Deposit date: | 2010-03-31 | Release date: | 2011-03-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54, 2011
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2X2R
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![BU of 2x2r by Molmil](/molmil-images/mine/2x2r) | Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid | Descriptor: | (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ... | Authors: | Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F. | Deposit date: | 2010-01-15 | Release date: | 2011-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5. J.Med.Chem., 54, 2011
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5ULC
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![BU of 5ulc by Molmil](/molmil-images/mine/5ulc) | PLASMODIUM FALCIPARUM BROMODOMAIN-CONTAINING PROTEIN PF10_0328 | Descriptor: | Bromodomain protein 1 | Authors: | Wernimont, A.K, Amaya, M.F, Lam, A, Ali, A, Zhang, A.Z, Kenzina, L, Lin, Y.H, MacKenzie, F, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Weigelt, J, Hui, R, Walker, J.R, Qiu, W, Brand, V, Structural Genomics Consortium (SGC) | Deposit date: | 2017-01-24 | Release date: | 2017-02-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | PLASMODIUM FALCIPARUM BROMODOMAIN-CONTAINING PROTEIN PF10_0328 To be published
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1EQX
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![BU of 1eqx by Molmil](/molmil-images/mine/1eqx) | SOLUTION STRUCTURE DETERMINATION AND MUTATIONAL ANALYSIS OF THE PAPILLOMAVIRUS E6-INTERACTING PEPTIDE OF E6AP | Descriptor: | PAPILLOMAVIRUS E6-ASSOCIATED PROTEIN | Authors: | Be, X, Hong, Y, Androphy, E.J, Chen, J.J, Baleja, J.D. | Deposit date: | 2000-04-06 | Release date: | 2001-02-28 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. Biochemistry, 40, 2001
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7MW4
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![BU of 7mw4 by Molmil](/molmil-images/mine/7mw4) | |
7MW6
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![BU of 7mw6 by Molmil](/molmil-images/mine/7mw6) | |
7MW3
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![BU of 7mw3 by Molmil](/molmil-images/mine/7mw3) | |
7MW2
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![BU of 7mw2 by Molmil](/molmil-images/mine/7mw2) | |
7MW5
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![BU of 7mw5 by Molmil](/molmil-images/mine/7mw5) | |
4R5Y
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![BU of 4r5y by Molmil](/molmil-images/mine/4r5y) | The complex structure of Braf V600E kinase domain with a novel Braf inhibitor | Descriptor: | 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one, Serine/threonine-protein kinase B-raf | Authors: | Feng, Y, Peng, H, Zhang, Y, Liu, Y, Wei, M. | Deposit date: | 2014-08-22 | Release date: | 2016-02-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol.Cancer Ther., 14, 2015
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