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7KUV
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BU of 7kuv by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Acetate
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, PHOSPHATE ION, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2020-11-25
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
Biochemistry, 60, 2021
7KJE
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BU of 7kje by Molmil
F96S epi-isozizaene synthase: complex with 3 Mg2+ and neridronate
Descriptor: (6-azanyl-1-oxidanyl-1-phosphono-hexyl)phosphonic acid, MAGNESIUM ION, SULFATE ION, ...
Authors:Ronnebaum, T.A, Gardner, S, Christianson, D.W.
Deposit date:2020-10-26
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways.
Biochemistry, 59, 2020
7KJ8
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BU of 7kj8 by Molmil
Wild-type epi-isozizaene synthase: complex with 3 Mg2+ and pamidronate
Descriptor: MAGNESIUM ION, PAMIDRONATE, SULFATE ION, ...
Authors:Ronnebaum, T.A, Gardner, S.M, Christianson, D.W.
Deposit date:2020-10-26
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways.
Biochemistry, 59, 2020
7KUT
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BU of 7kut by Molmil
Crystal Structure of Danio rerio Histone Deacetylase 10 H137A Mutant in Complex with N-Acetylputrescine (Tetrahedral Intermediate)
Descriptor: 1,2-ETHANEDIOL, 1-[(4-aminobutyl)amino]ethane-1,1-diol, DI(HYDROXYETHYL)ETHER, ...
Authors:Herbst-Gervasoni, C.J, Christianson, D.W.
Deposit date:2020-11-25
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
Biochemistry, 60, 2021
7JVW
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BU of 7jvw by Molmil
Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344
Descriptor: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ...
Authors:Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M.
Deposit date:2020-08-24
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.40301776 Å)
Cite:Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
J.Struct.Biol., 213, 2020
7JVV
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Crystal structure of human histone deacetylase 8 (HDAC8) E66D/Y306F double mutation complexed with a tetrapeptide substrate
Descriptor: 1,2-ETHANEDIOL, ACE-ARG-HIS-ALY-ALY-MCM, GLYCEROL, ...
Authors:Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M.
Deposit date:2020-08-24
Release date:2020-12-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
J.Struct.Biol., 213, 2020
7JVU
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BU of 7jvu by Molmil
Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA
Descriptor: 1,2-ETHANEDIOL, Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ...
Authors:Osko, J.D, Christianson, D.W, Decroos, C, Porter, N.J, Lee, M.
Deposit date:2020-08-24
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5004766 Å)
Cite:Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
J.Struct.Biol., 213, 2020
7JOM
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BU of 7jom by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with TO-317
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, Hdac6 protein, ...
Authors:Watson, P.R, Christianson, D.W.
Deposit date:2020-08-06
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.
J.Med.Chem., 64, 2021
12CA
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BU of 12ca by Molmil
ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1991-10-01
Release date:1992-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
J.Biol.Chem., 266, 1991
1CA3
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BU of 1ca3 by Molmil
UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II.
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Nair, S.K, Christianson, D.W.
Deposit date:1991-11-18
Release date:1992-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II.
J.Am.Chem.Soc., 113, 1991
1CNG
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BU of 1cng by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, CHLORIDE ION, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNH
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BU of 1cnh by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CIM
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BU of 1cim by Molmil
THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
Descriptor: (4S-TRANS)-4-(AMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO (2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ...
Authors:Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
Protein Sci., 3, 1994
1CNX
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BU of 1cnx by Molmil
SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
Descriptor: AMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Boriack, P.A, Christianson, D.W.
Deposit date:1995-07-21
Release date:1995-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
J.Med.Chem., 38, 1995
1CNI
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BU of 1cni by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNW
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BU of 1cnw by Molmil
SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
Descriptor: AMINOMETHYLENECARBONYLAMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Boriack, P.A, Christianson, D.W.
Deposit date:1995-07-21
Release date:1995-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
J.Med.Chem., 38, 1995
1CIL
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BU of 1cil by Molmil
THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
Descriptor: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, ZINC ION
Authors:Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
Protein Sci., 3, 1994
1CNY
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BU of 1cny by Molmil
SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE, ...
Authors:Boriack, P.A, Christianson, D.W.
Deposit date:1995-07-21
Release date:1995-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
J.Med.Chem., 38, 1995
1CIN
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BU of 1cin by Molmil
THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS
Descriptor: (4S-TRANS)-4-(METHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, CARBONIC ANHYDRASE II, METHYL MERCURY ION, ...
Authors:Smith, G.M, Alexander, R.S, Christianson, D.W, Mckeever, B.M, Ponticello, G.S, Springer, J.P, Randall, W.C, Baldwin, J.J, Habecker, C.N.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
Protein Sci., 3, 1994
1CPS
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BU of 1cps by Molmil
STRUCTURAL COMPARISON OF SULFODIIMINE AND SULFONAMIDE INHIBITORS IN THEIR COMPLEXES WITH ZINC ENZYMES
Descriptor: CARBOXYPEPTIDASE A, S-(2-CARBOXY-3-PHENYLPROPYL)THIODIIMINE-S-METHANE, ZINC ION
Authors:Cappalonga, A.M, Alexander, R.S, Christianson, D.W.
Deposit date:1992-02-18
Release date:1993-10-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes.
J.Biol.Chem., 267, 1992
1CCU
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BU of 1ccu by Molmil
STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CCT
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BU of 1cct by Molmil
STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CCS
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BU of 1ccs by Molmil
STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A, Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CNK
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BU of 1cnk by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CR6
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BU of 1cr6 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(PROPYL)PHENYL UREA
Authors:Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:1999-08-13
Release date:1999-11-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999

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數據於2024-06-12公開中

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