5XIL
| Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS) | Descriptor: | ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
5XIG
| Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1 | Descriptor: | 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
5XIP
| Crystal Structure of Eimeria tenella Prolyl-tRNA Synthetase (EtPRS) in complex with Halofuginone | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
5XIH
| Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 5 | Descriptor: | 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
6LHM
| Structure of human PYCR2 | Descriptor: | Pyrroline-5-carboxylate reductase 2 | Authors: | Baburajendran, N. | Deposit date: | 2019-12-09 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron, 107, 2020
|
|
6LBW
| |
5XIK
| Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with tetrahydro quinazolinone febrifugine | Descriptor: | 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
5XIO
| Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
5XIJ
| Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9 | Descriptor: | 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
|
|
2Z3K
| complex structure of LF-transferase and rAF | Descriptor: | 2-(6-AMINO-OCTAHYDRO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, D(-)-TARTARIC ACID, Leucyl/phenylalanyl-tRNA-protein transferase, ... | Authors: | Watanabe, K, Toh, Y, Tomita, K. | Deposit date: | 2007-06-04 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase Nature, 449, 2007
|
|
2Z3M
| complex structure of LF-transferase and dAF | Descriptor: | (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, D(-)-TARTARIC ACID, Leucyl/phenylalanyl-tRNA-protein transferase, ... | Authors: | Watanabe, K, Toh, Y, Tomita, K. | Deposit date: | 2007-06-04 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase Nature, 449, 2007
|
|
2Z3L
| complex structure of LF-transferase and peptide A | Descriptor: | D(-)-TARTARIC ACID, Leucyl/phenylalanyl-tRNA-protein transferase, peptide (PHE)(ARG)(TYR)(LEU)(GLY) | Authors: | Watanabe, K, Toh, Y, Tomita, K. | Deposit date: | 2007-06-04 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase Nature, 449, 2007
|
|
2Z3P
| |
2Z3O
| |
2Z3N
| complex structure of LF-transferase and peptide B | Descriptor: | D(-)-TARTARIC ACID, Leucyl/phenylalanyl-tRNA-protein transferase, peptide (PHE)(ARG)(TYR)(LEU)(GLY) | Authors: | Watanabe, K, Toh, Y, Tomita, K. | Deposit date: | 2007-06-04 | Release date: | 2007-10-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase Nature, 449, 2007
|
|
3AN3
| Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO3S | Descriptor: | (2S)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K. | Deposit date: | 2010-08-30 | Release date: | 2011-07-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship J.Med.Chem., 54, 2011
|
|
3AN4
| Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R | Descriptor: | (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Oyama, T, Ohashi, M, Waku, T, Miyachi, H, Morikawa, K. | Deposit date: | 2010-08-30 | Release date: | 2011-07-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship J.Med.Chem., 54, 2011
|
|
2GD3
| NMR structure of S14G-humanin in 30% TFE solution | Descriptor: | Humanin | Authors: | Benaki, D, Zikos, C, Evangelou, A, Livaniou, E, Vlassi, M, Mikros, E, Pelecanou, M. | Deposit date: | 2006-03-15 | Release date: | 2006-09-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. Biochem.Biophys.Res.Commun., 349, 2006
|
|
7CBF
| Crystal structure of benzophenone synthase from Garcinia mangostana L. pericarps reveals basis for substrate specificity and catalysis | Descriptor: | 2,4,6-trihydroxybenzophenone synthase, GLYCEROL, IMIDAZOLE, ... | Authors: | Songsiriritthigul, C, Nualkaew, N, Chen, C.-J. | Deposit date: | 2020-06-12 | Release date: | 2020-12-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Crystal structure of benzophenone synthase from Garcinia mangostana L. pericarps reveals basis for substrate specificity and catalysis. Acta Crystallogr.,Sect.F, 76, 2020
|
|
8JOK
| |
8JQW
| |
8JNU
| |
2FLH
| Crystal structure of cytokinin-specific binding protein from mung bean in complex with cytokinin | Descriptor: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, SODIUM ION, cytokinin-specific binding protein | Authors: | Pasternak, O, Bujacz, G.D, Sikorski, M.M, Jaskolski, M. | Deposit date: | 2006-01-06 | Release date: | 2006-11-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal Structure of Vigna radiata Cytokinin-Specific Binding Protein in Complex with Zeatin. Plant Cell, 18, 2006
|
|
1UBB
| Crystal structure of rat HO-1 in complex with ferrous heme | Descriptor: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sugishima, M, Sakamoto, H, Higashimoto, Y, Noguchi, M, Fukuyama, K. | Deposit date: | 2003-04-03 | Release date: | 2003-09-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
|
|
5XRZ
| Structure of a ssDNA bound to the inner DNA binding site of RAD52 | Descriptor: | DNA repair protein RAD52 homolog, POTASSIUM ION, ssDNA (40-MER) | Authors: | Saotome, M, Saito, K, Yasuda, T, Sugiyama, S, Kurumizaka, H, Kagawa, W. | Deposit date: | 2017-06-11 | Release date: | 2018-04-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural Basis of Homology-Directed DNA Repair Mediated by RAD52 iScience, 3, 2018
|
|