4IBY
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![BU of 4iby by Molmil](/molmil-images/mine/4iby) | Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | Authors: | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBQ
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![BU of 4ibq by Molmil](/molmil-images/mine/4ibq) | Human p53 core domain with hot spot mutation R273C | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBS
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![BU of 4ibs by Molmil](/molmil-images/mine/4ibs) | Human p53 core domain with hot spot mutation R273H (form I) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | Authors: | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IJT
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![BU of 4ijt by Molmil](/molmil-images/mine/4ijt) | Human p53 core domain with hot spot mutation R273H (form II) | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2012-12-23 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBT
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![BU of 4ibt by Molmil](/molmil-images/mine/4ibt) | Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Diskin-Posner, Y, Eldar, A, Rozenberg, H, Shakked, Z. | Deposit date: | 2012-12-09 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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189D
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![BU of 189d by Molmil](/molmil-images/mine/189d) | |
7B4D
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![BU of 7b4d by Molmil](/molmil-images/mine/7b4d) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4N
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![BU of 7b4n by Molmil](/molmil-images/mine/7b4n) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B49
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![BU of 7b49 by Molmil](/molmil-images/mine/7b49) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B48
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![BU of 7b48 by Molmil](/molmil-images/mine/7b48) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) | Descriptor: | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4G
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![BU of 7b4g by Molmil](/molmil-images/mine/7b4g) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (II) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4H
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![BU of 7b4h by Molmil](/molmil-images/mine/7b4h) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4A
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![BU of 7b4a by Molmil](/molmil-images/mine/7b4a) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA: R273H-DNA | Descriptor: | Cellular tumor antigen p53, DNA target, FORMIC ACID, ... | Authors: | Golovenko, D, Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B47
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![BU of 7b47 by Molmil](/molmil-images/mine/7b47) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (I) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4B
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![BU of 7b4b by Molmil](/molmil-images/mine/7b4b) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4C
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![BU of 7b4c by Molmil](/molmil-images/mine/7b4c) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (II) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B46
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![BU of 7b46 by Molmil](/molmil-images/mine/7b46) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (P1) | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, ACETATE ION, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4F
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![BU of 7b4f by Molmil](/molmil-images/mine/7b4f) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA: R282W-MQ (I) | Descriptor: | Cellular tumor antigen p53, DNA target, FORMIC ACID, ... | Authors: | Rozenberg, H, Degtjarik, O, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4E
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![BU of 7b4e by Molmil](/molmil-images/mine/7b4e) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ | Descriptor: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | Authors: | Degtjarik, O, Rozenberg, H, Shakked, Z. | Deposit date: | 2020-12-02 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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5MCU
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![BU of 5mcu by Molmil](/molmil-images/mine/5mcu) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... | Authors: | Golovenko, D, Rozenberg, H, Shakked, Z. | Deposit date: | 2016-11-10 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5MCV
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![BU of 5mcv by Molmil](/molmil-images/mine/5mcv) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC1) | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | Authors: | Golovenko, D, Rozenberg, H, Shakked, Z. | Deposit date: | 2016-11-10 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5MCW
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![BU of 5mcw by Molmil](/molmil-images/mine/5mcw) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2) | Descriptor: | Cellular tumor antigen p53, DNA, FORMYL GROUP, ... | Authors: | Golovenko, D, Rozenberg, H, Shakked, Z. | Deposit date: | 2016-11-10 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5MF7
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![BU of 5mf7 by Molmil](/molmil-images/mine/5mf7) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45) | Descriptor: | Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, DNA, ... | Authors: | Rozenberg, H, Diskin-Posner, Y, Golovenko, D, Shakked, Z. | Deposit date: | 2016-11-17 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5MCT
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![BU of 5mct by Molmil](/molmil-images/mine/5mct) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG1) | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ... | Authors: | Golovenko, D, Rozenberg, H, Shakked, Z. | Deposit date: | 2016-11-10 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.446 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5MG7
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![BU of 5mg7 by Molmil](/molmil-images/mine/5mg7) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-p53R2) | Descriptor: | Cellular tumor antigen p53, DNA, ZINC ION | Authors: | Rozenberg, H, Braeuning, B, Golovenko, D, Shakked, Z. | Deposit date: | 2016-11-21 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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