6CXK
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![BU of 6cxk by Molmil](/molmil-images/mine/6cxk) | E. coli DHFR substrate complex with Dihydrofolate | Descriptor: | CHLORIDE ION, DIHYDROFOLIC ACID, Dihydrofolate reductase, ... | Authors: | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | Deposit date: | 2018-04-03 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.108 Å) | Cite: | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
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6CW7
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![BU of 6cw7 by Molmil](/molmil-images/mine/6cw7) | E. coli DHFR product complex with (6S)-5,6,7,8-TETRAHYDROFOLATE | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, Dihydrofolate reductase, ... | Authors: | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | Deposit date: | 2018-03-30 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
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6CQA
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![BU of 6cqa by Molmil](/molmil-images/mine/6cqa) | E. coli DHFR complex with inhibitor AMPQD | Descriptor: | 7-[(3-aminophenyl)methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, SULFATE ION | Authors: | Cao, H, Rodrigues, J, Benach, J, Wasserman, S, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | Deposit date: | 2018-03-14 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
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3F81
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![BU of 3f81 by Molmil](/molmil-images/mine/3f81) | Interaction of VHR with SA3 | Descriptor: | 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid, Dual specificity protein phosphatase 3 | Authors: | Wu, S, Mutelin, T, Tautz, L. | Deposit date: | 2008-11-11 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J.Med.Chem., 52, 2009
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5TY4
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![BU of 5ty4 by Molmil](/molmil-images/mine/5ty4) | MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution | Descriptor: | TGF-beta receptor type-2, mmTGF-b2-7m | Authors: | Weiss, S.C, de la Cruz, M.J, Hattne, J, Shi, D, Reyes, F.E, Callero, G, Gonen, T. | Deposit date: | 2016-11-18 | Release date: | 2017-04-26 | Last modified: | 2023-10-04 | Method: | ELECTRON CRYSTALLOGRAPHY (2.9 Å) | Cite: | Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat. Methods, 14, 2017
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2O36
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7R1E
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![BU of 7r1e by Molmil](/molmil-images/mine/7r1e) | Mosquitocidal Cry11Ba determined at pH 10.4 from naturally-occurring nanocrystals by Serial femtosecond crystallography | Descriptor: | GLYCEROL, Pesticidal crystal protein Cry11Ba | Authors: | Colletier, J.-P, Sawaya, M.R, Schibrowsky, N.A, Cascio, D, Rodriguez, J.A. | Deposit date: | 2022-02-02 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. Nat Commun, 13, 2022
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7QYD
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![BU of 7qyd by Molmil](/molmil-images/mine/7qyd) | mosquitocidal Cry11Ba determined at pH 6.5 from naturally-occurring nanocrystals by Serial femtosecond crystallography | Descriptor: | Pesticidal crystal protein Cry11Ba | Authors: | De Zitter, E, Tetreau, G, Andreeva, E.A, Coquelle, N, Colletier, J.-P, Sawaya, M.R, Schibrowsky, N.A, Cascio, D, Rodriguez, J.A. | Deposit date: | 2022-01-28 | Release date: | 2022-07-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. Nat Commun, 13, 2022
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5K2F
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![BU of 5k2f by Molmil](/molmil-images/mine/5k2f) | Structure of NNQQNY from yeast prion Sup35 with cadmium acetate determined by MicroED | Descriptor: | ACETATE ION, CADMIUM ION, Eukaryotic peptide chain release factor GTP-binding subunit | Authors: | Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2016-05-18 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc.Natl.Acad.Sci.USA, 113, 2016
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5K2E
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![BU of 5k2e by Molmil](/molmil-images/mine/5k2e) | Structure of NNQQNY from yeast prion Sup35 with zinc acetate determined by MicroED | Descriptor: | ACETIC ACID, Eukaryotic peptide chain release factor GTP-binding subunit, ZINC ION | Authors: | Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2016-05-18 | Release date: | 2016-09-14 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc.Natl.Acad.Sci.USA, 113, 2016
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5K2G
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7NZ9
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7NZ7
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![BU of 7nz7 by Molmil](/molmil-images/mine/7nz7) | Crystal structure of mouse ADAT2/ADAT3 tRNA deamination complex 1 | Descriptor: | Probable inactive tRNA-specific adenosine deaminase-like protein 3, ZINC ION, tRNA-specific adenosine deaminase 2 | Authors: | Ramos Morales, E, Romier, C. | Deposit date: | 2021-03-23 | Release date: | 2021-05-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination. Nucleic Acids Res., 49, 2021
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5K2H
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7NZ8
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![BU of 7nz8 by Molmil](/molmil-images/mine/7nz8) | Crystal structure of mouse ADAT2/ADAT3 tRNA deamination complex 2 | Descriptor: | Probable inactive tRNA-specific adenosine deaminase-like protein 3, ZINC ION, tRNA-specific adenosine deaminase 2 | Authors: | Ramos Morales, E, Romier, C. | Deposit date: | 2021-03-23 | Release date: | 2021-05-05 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination. Nucleic Acids Res., 49, 2021
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8CTO
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![BU of 8cto by Molmil](/molmil-images/mine/8cto) | |
8CUN
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8CWA
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![BU of 8cwa by Molmil](/molmil-images/mine/8cwa) | |
7JUM
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![BU of 7jum by Molmil](/molmil-images/mine/7jum) | Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 | Descriptor: | Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv | Authors: | Tolia, N, Tang, W.K. | Deposit date: | 2020-08-20 | Release date: | 2021-03-31 | Last modified: | 2021-04-07 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nat Commun, 12, 2021
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6I9J
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![BU of 6i9j by Molmil](/molmil-images/mine/6i9j) | Human transforming growth factor beta2 in a tetragonal crystal form | Descriptor: | Transforming growth factor beta-2 proprotein | Authors: | Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. | Deposit date: | 2018-11-23 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation. Sci Rep, 9, 2019
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7UBF
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![BU of 7ubf by Molmil](/molmil-images/mine/7ubf) | |
7UBD
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7UBI
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7UCP
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![BU of 7ucp by Molmil](/molmil-images/mine/7ucp) | computationally designed macrocycle | Descriptor: | computationally designed cyclic peptide D8.3.p2 | Authors: | Bhardwaj, G, Baker, D, Rettie, S, Glynn, C, Sawaya, M. | Deposit date: | 2022-03-17 | Release date: | 2022-09-14 | Last modified: | 2022-09-28 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Accurate de novo design of membrane-traversing macrocycles. Cell, 185, 2022
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7UZL
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![BU of 7uzl by Molmil](/molmil-images/mine/7uzl) | |