1A5T
| CRYSTAL STRUCTURE OF THE DELTA PRIME SUBUNIT OF THE CLAMP-LOADER COMPLEX OF ESCHERICHIA COLI DNA POLYMERASE III | Descriptor: | DELTA PRIME, ZINC ION | Authors: | Guenther, B, Onrust, R, Sali, A, O'Donnell, M, Kuriyan, J. | Deposit date: | 1998-02-18 | Release date: | 1998-05-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III. Cell(Cambridge,Mass.), 91, 1997
|
|
3U60
| Structure of T4 Bacteriophage Clamp Loader Bound To Open Clamp, DNA and ATP Analog | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | Authors: | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | Deposit date: | 2011-10-11 | Release date: | 2012-01-04 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | How a DNA polymerase clamp loader opens a sliding clamp. Science, 334, 2011
|
|
1CZD
| CRYSTAL STRUCTURE OF THE PROCESSIVITY CLAMP GP45 FROM BACTERIOPHAGE T4 | Descriptor: | DNA POLYMERASE ACCESSORY PROTEIN G45 | Authors: | Moarefi, I, Jeruzalmi, D, Turner, J, O'Donnell, M, Kuriyan, J. | Deposit date: | 1999-09-02 | Release date: | 2000-03-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage. J.Mol.Biol., 296, 2000
|
|
8UNF
| Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp and DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Sliding clamp, ... | Authors: | Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J. | Deposit date: | 2023-10-18 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
|
|
8UNH
| Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Sliding clamp, ... | Authors: | Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J. | Deposit date: | 2023-10-19 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
|
|
6U0M
| Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | Deposit date: | 2019-08-14 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nat Commun, 11, 2020
|
|
8FOJ
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
8FOH
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
8FOC
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
8FOE
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
8FOK
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
8FOD
| Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | Deposit date: | 2022-12-30 | Release date: | 2023-05-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase. Nat Commun, 14, 2023
|
|
6WJV
| Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | Descriptor: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... | Authors: | Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. | Deposit date: | 2020-04-14 | Release date: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome. Nat Commun, 11, 2020
|
|
8UK9
| Structure of T4 Bacteriophage clamp loader mutant D110C bound to the T4 clamp, primer-template DNA, and ATP analog | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, DNA primer, ... | Authors: | Marcus, K, Ghaffari-Kashani, S, Gee, C.L. | Deposit date: | 2023-10-12 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
|
|
3GLI
| Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | Authors: | Simonetta, K.R, Cantor, A.J, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
|
|
2POL
| |
3GLH
| Crystal Structure of the E. coli clamp loader bound to Psi Peptide | Descriptor: | DNA polymerase III subunit delta, DNA polymerase III subunit delta', DNA polymerase III subunit tau | Authors: | Kazmirski, S.L, Simonetta, K.R, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.891 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
|
|
3PWE
| Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution | Descriptor: | DNA polymerase III subunit beta | Authors: | Marzahn, M.R, Robbins, A.H, McKenna, R, Bloom, L.B. | Deposit date: | 2010-12-08 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | The E. coli clamp loader can actively pry open the beta-sliding clamp J.Biol.Chem., 286, 2011
|
|
8UH7
| Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Primer DNA strand, ... | Authors: | Gee, C.L, Marcus, K, Kelch, B.A, Makino, D.L. | Deposit date: | 2023-10-07 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.628 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
|
|
1AXC
| HUMAN PCNA | Descriptor: | P21/WAF1, PCNA | Authors: | Gulbis, J.M, Kuriyan, J. | Deposit date: | 1997-10-14 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell(Cambridge,Mass.), 87, 1996
|
|
3GLG
| Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | Authors: | Simonetta, K.R, Seyedin, S.N, Kuriyan, J. | Deposit date: | 2009-03-12 | Release date: | 2009-05-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell(Cambridge,Mass.), 137, 2009
|
|
3GLF
| |
3K4X
| Eukaryotic Sliding Clamp PCNA Bound to DNA | Descriptor: | DNA (5'-D(*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), Proliferating cell nuclear antigen | Authors: | McNally, R, Kuriyan, J. | Deposit date: | 2009-10-06 | Release date: | 2010-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Analysis of the role of PCNA-DNA contacts during clamp loading. Bmc Struct.Biol., 10, 2010
|
|
1OK7
| A Conserved protein binding-site on Bacterial Sliding Clamps | Descriptor: | DNA POLYMERASE III, DNA POLYMERASE IV | Authors: | Burnouf, D.Y, Olieric, V, Wagner, J, Fujii, S, Reinbolt, J, Fuchs, R.P.P, Dumas, P. | Deposit date: | 2003-07-18 | Release date: | 2004-07-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural and Biochemical Analysis of Sliding Clamp/Ligand Interactions Suggest a Competition between Replicative and Translesion DNA Polymerases J.Mol.Biol., 335, 2004
|
|