7T7O
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7T7K
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![BU of 7t7k by Molmil](/molmil-images/mine/7t7k) | Structure of SPAC806.04c protein from fission yeast bound to Co2+ | Descriptor: | CHLORIDE ION, COBALT (II) ION, Damage-control phosphatase SPAC806.04c, ... | Authors: | Jacewicz, A, Sanchez, A.M, Shuman, S. | Deposit date: | 2021-12-15 | Release date: | 2022-06-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J.Biol.Chem., 298, 2022
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4YKL
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![BU of 4ykl by Molmil](/molmil-images/mine/4ykl) | Hnt3 in complex with DNA and guanosine | Descriptor: | Aprataxin-like protein, CHLORIDE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | Deposit date: | 2015-03-04 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Res., 43, 2015
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4KHN
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![BU of 4khn by Molmil](/molmil-images/mine/4khn) | Crystal structure of the ternary complex of the D714A mutant of RB69 DNA polymerase | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | Authors: | Guja, K.E, Jacewicz, A, Trzemecka, A, Plochocka, D, Yakubovskaya, E, Bebenek, A, Garcia-Diaz, M. | Deposit date: | 2013-04-30 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site. Plos One, 8, 2013
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4XBA
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![BU of 4xba by Molmil](/molmil-images/mine/4xba) | Hnt3 | Descriptor: | Aprataxin-like protein, GLYCEROL, GUANOSINE, ... | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | Deposit date: | 2014-12-16 | Release date: | 2015-06-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Res., 43, 2015
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7U1Y
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![BU of 7u1y by Molmil](/molmil-images/mine/7u1y) | Structure of SPAC806.04c protein from fission yeast bound to AlF4 and Co2+ | Descriptor: | COBALT (II) ION, Damage-control phosphatase SPAC806.04c, POTASSIUM ION, ... | Authors: | Jacewicz, A, Sanchez, A.M, Shuman, S. | Deposit date: | 2022-02-22 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J.Biol.Chem., 298, 2022
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7U1V
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![BU of 7u1v by Molmil](/molmil-images/mine/7u1v) | Structure of SPAC806.04c protein from fission yeast covalently bound to BeF3 | Descriptor: | Damage-control phosphatase SPAC806.04c, NICKEL (II) ION, PHOSPHATE ION, ... | Authors: | Jacewicz, A, Sanchez, A.M, Shuman, S. | Deposit date: | 2022-02-22 | Release date: | 2022-06-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J.Biol.Chem., 298, 2022
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7U1X
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4I9Q
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![BU of 4i9q by Molmil](/molmil-images/mine/4i9q) | Crystal structure of the ternary complex of the D714A mutant of RB69 DNA polymerase | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | Authors: | Guja, K.E, Jacewicz, A, Trzemecka, A, Plochocka, D, Yakubovskaya, E, Bebenek, A, Garcia-Diaz, M. | Deposit date: | 2012-12-05 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Remote Palm Domain Residue of RB69 DNA Polymerase Is Critical for Enzyme Activity and Influences the Conformation of the Active Site. Plos One, 8, 2013
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5V9X
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![BU of 5v9x by Molmil](/molmil-images/mine/5v9x) | Structure of Mycobacterium smegmatis helicase Lhr bound to ssDNA and AMP-PNP | Descriptor: | ATP-dependent DNA helicase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Ordonez, H, Jacewicz, A, Ferrao, R, Shuman, S. | Deposit date: | 2017-03-23 | Release date: | 2017-12-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.797 Å) | Cite: | Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res., 46, 2018
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6XQN
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![BU of 6xqn by Molmil](/molmil-images/mine/6xqn) | Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in low Ca2+ | Descriptor: | CALCIUM ION, Calcium uniporter protein, Calcium uptake protein 1, ... | Authors: | Long, S.B, Wang, C, Baradaran, R, Jacewicz, A, Delgado, B. | Deposit date: | 2020-07-09 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures reveal gatekeeping of the mitochondrial Ca 2+ uniporter by MICU1-MICU2. Elife, 9, 2020
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6XQO
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![BU of 6xqo by Molmil](/molmil-images/mine/6xqo) | Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc | Descriptor: | CALCIUM ION, Calcium uptake protein 1, mitochondrial, ... | Authors: | Long, S.B, Wang, C, Baradaran, R, Jacewicz, A, Delgado, B. | Deposit date: | 2020-07-09 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structures reveal gatekeeping of the mitochondrial Ca 2+ uniporter by MICU1-MICU2. Elife, 9, 2020
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4MDE
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![BU of 4mde by Molmil](/molmil-images/mine/4mde) | Structure of bacterial polynucleotide kinase product complex bound to GDP and DNA | Descriptor: | DNA (5'-D(P*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | Deposit date: | 2013-08-22 | Release date: | 2013-11-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
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4MDF
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![BU of 4mdf by Molmil](/molmil-images/mine/4mdf) | Structure of bacterial polynucleotide kinase Michaelis complex bound to GTP and DNA | Descriptor: | CITRIC ACID, DNA (5'-D(*CP*CP*TP*GP*T)-3'), GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Shuman, S, Das, U, Wang, L.K, Smith, P, Jacewicz, A. | Deposit date: | 2013-08-22 | Release date: | 2013-11-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.727 Å) | Cite: | Structures of bacterial polynucleotide kinase in a Michaelis complex with GTP*Mg2+ and 5'-OH oligonucleotide and a product complex with GDP*Mg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Nucleic Acids Res., 42, 2014
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2XU8
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![BU of 2xu8 by Molmil](/molmil-images/mine/2xu8) | Structure of Pa1645 | Descriptor: | PA1645, SULFATE ION | Authors: | Abdelli, W.B, Moynie, L, McMahon, S.A, Liu, H, Alphey, M.S, Naismith, J.H. | Deposit date: | 2010-10-15 | Release date: | 2010-12-29 | Last modified: | 2015-08-19 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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4ETR
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![BU of 4etr by Molmil](/molmil-images/mine/4etr) | X-ray structure of PA2169 from Pseudomonas aeruginosa | Descriptor: | Putative uncharacterized protein | Authors: | Schnell, R, Sandalova, T, Lindqvist, Y, Schneider, G. | Deposit date: | 2012-04-24 | Release date: | 2013-01-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4EXB
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4ES6
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4EXA
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![BU of 4exa by Molmil](/molmil-images/mine/4exa) | Crystal structure of the PA4992, the putative aldo-keto reductase from Pseudomona aeruginosa | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative uncharacterized protein | Authors: | Sandalova, T, Schnell, R, Schneider, G. | Deposit date: | 2012-04-30 | Release date: | 2013-01-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4B9A
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![BU of 4b9a by Molmil](/molmil-images/mine/4b9a) | Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa. | Descriptor: | GLYCEROL, PROBABLE EPOXIDE HYDROLASE, SULFATE ION | Authors: | Schmidberger, J.W, Schnell, R, Schneider, G. | Deposit date: | 2012-09-03 | Release date: | 2013-02-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4AVF
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![BU of 4avf by Molmil](/molmil-images/mine/4avf) | Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | Descriptor: | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE | Authors: | McMahon, S.A, Moynie, L, Liu, H, Duthie, F, Naismith, J.H. | Deposit date: | 2012-05-25 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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4B7C
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![BU of 4b7c by Molmil](/molmil-images/mine/4b7c) | Crystal structure of hypothetical protein PA1648 from Pseudomonas aeruginosa. | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PROBABLE OXIDOREDUCTASE | Authors: | Alphey, M.S, McMahon, S.A, Duthie, F.G, Naismith, J.H. | Deposit date: | 2012-08-17 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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4B9E
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![BU of 4b9e by Molmil](/molmil-images/mine/4b9e) | Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA. | Descriptor: | GLYCEROL, PROBABLE EPOXIDE HYDROLASE, SULFATE ION, ... | Authors: | Schmidberger, J.W, Schnell, R, Schneider, G. | Deposit date: | 2012-09-04 | Release date: | 2013-02-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4B7X
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![BU of 4b7x by Molmil](/molmil-images/mine/4b7x) | Crystal structure of hypothetical protein PA1648 from Pseudomonas aeruginosa. | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROBABLE OXIDOREDUCTASE | Authors: | Alphey, M.S, McMahon, S.A, Duthie, F, Naismith, J.H. | Deposit date: | 2012-08-24 | Release date: | 2013-01-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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4AVY
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![BU of 4avy by Molmil](/molmil-images/mine/4avy) | The AEROPATH project and Pseudomonas aeruginosa high-throughput crystallographic studies for assessment of potential targets in early stage drug discovery. | Descriptor: | PROBABLE SHORT-CHAIN DEHYDROGENASE | Authors: | Moynie, L, McMahon, S.A, Alphey, M.S, Liu, H, Duthie, F, Naismith, J.H. | Deposit date: | 2012-05-30 | Release date: | 2012-12-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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