4AVY

The AEROPATH project and Pseudomonas aeruginosa high-throughput crystallographic studies for assessment of potential targets in early stage drug discovery.

Summary for 4AVY

DescriptorPROBABLE SHORT-CHAIN DEHYDROGENASE (2 entities in total)
Functional Keywordsoxidoreductase, infectious disease, structure-based inhibitor design
Biological sourcePSEUDOMONAS AERUGINOSA PA01
Total number of polymer chains2
Total molecular weight51410.6
Authors
Moynie, L.,McMahon, S.A.,Alphey, M.S.,Liu, H.,Duthie, F.,Naismith, J.H. (deposition date: 2012-05-30, release date: 2012-12-12, Last modification date: 2013-01-23)
Primary citation
Moynie, L.,Schnell, R.,Mcmahon, S.A.,Sandalova, T.,Boulkerou, W.A.,Schmidberger, J.W.,Alphey, M.S.,Cukier, C.,Duthie, F.,Kopec, J.,Liu, H.,Jacewicz, A.,Hunter, W.N.,Naismith, J.H.,Schneider, G.
The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery
Acta Crystallogr.,Sect.F, 69:25-, 2013
PubMed: 23295481 (PDB entries with the same primary citation)
DOI: 10.1107/S1744309112044739
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.183200.3%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution