1TDT
 
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2W7Z
 | | Structure of the pentapeptide repeat protein EfsQnr, a DNA gyrase inhibitor. Free amines modified by cyclic pentylation with glutaraldehyde. | | Descriptor: | CHLORIDE ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN | | Authors: | Vetting, M.W, Hegde, S.S, Blanchard, J.S. | | Deposit date: | 2009-01-06 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystallization of a Pentapeptide-Repeat Protein by Reductive Cyclic Pentylation of Free Amines with Glutaraldehyde.
Acta Crystallogr.,Sect.D, 65, 2009
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2VZY
 | | Crystal structure of Rv0802c from Mycobacterium tuberculosis in an unliganded form. | | Descriptor: | 2-ETHOXYETHANOL, ACETATE ION, CITRATE ANION, ... | | Authors: | Vetting, M.W, Errey, J.C, Blanchard, J.S. | | Deposit date: | 2008-08-07 | | Release date: | 2009-04-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Rv0802C from Mycobacterium Tuberculosis: The First Structure of a Succinyltransferase with the Gnat Fold.
Acta Crystallogr.,Sect.F, 64, 2008
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2VZZ
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2VQY
 | | Structure of AAC(6')-Ib in complex with Parmomycin and AcetylCoA. | | Descriptor: | AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ... | | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | | Deposit date: | 2008-03-20 | | Release date: | 2008-09-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Biochemistry, 47, 2008
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2X9Q
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6C37
 | | Mycobacterium smegmatis RimJ in complex with CoA-disulfide | | Descriptor: | Acetyltransferase, GNAT family protein, [[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate | | Authors: | Favrot, L, Hegde, S.S, Blanchard, J.S. | | Deposit date: | 2018-01-09 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.696 Å) | | Cite: | Structural Characterization of Mycobacterium smegmatis RimJ, an N-acetyltransferase protein
To Be Published
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2VBQ
 | | Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. | | Descriptor: | (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, GLYCEROL, ... | | Authors: | Vetting, M.W, Magalhaes, M.L, Freiburger, L, Gao, F, Auclair, K, Blanchard, J.S. | | Deposit date: | 2007-09-14 | | Release date: | 2008-01-08 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase.
Biochemistry, 47, 2008
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6C30
 | | Mycobacterium smegmatis RimJ (apo form) | | Descriptor: | CHLORIDE ION, GLYCEROL, GNAT family acetyltransferase | | Authors: | Favrot, L, Hegde, S.S, Blanchard, J.S. | | Deposit date: | 2018-01-09 | | Release date: | 2019-01-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.397 Å) | | Cite: | Structural Characterization of Mycobacterium smegmatis RimJ, an N-acetyltransferase protein
To Be Published
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6C32
 | | Mycobacterium smegmatis RimJ with AcCoA | | Descriptor: | ACETYL COENZYME *A, Acetyltransferase, GNAT family protein | | Authors: | Favrot, L, Hegde, S.S, Blanchard, J.S. | | Deposit date: | 2018-01-09 | | Release date: | 2019-01-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.898 Å) | | Cite: | Structural Characterization of Mycobacterium smegmatis RimJ, an N-acetyltransferase protein
To Be Published
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1ARZ
 | | ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DIHYDRODIPICOLINATE REDUCTASE, PHOSPHATE ION, ... | | Authors: | Scapin, G, Reddy, S.G, Zheng, R, Blanchard, J.S. | | Deposit date: | 1997-08-08 | | Release date: | 1998-10-14 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
Biochemistry, 36, 1997
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3DWZ
 | | Meropenem Covalent Adduct with TB Beta-lactamase | | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | Authors: | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | | Deposit date: | 2008-07-23 | | Release date: | 2009-03-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
Science, 323, 2009
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1DRV
 | | ESCHERICHIA COLI DHPR/ACNADH COMPLEX | | Descriptor: | 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE, DIHYDRODIPICOLINATE REDUCTASE | | Authors: | Reddy, S.G, Scapin, G, Blanchard, J.S. | | Deposit date: | 1996-06-28 | | Release date: | 1997-01-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes.
Biochemistry, 35, 1996
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1DRU
 | | ESCHERICHIA COLI DHPR/NADH COMPLEX | | Descriptor: | DIHYDRODIPICOLINATE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Reddy, S.G, Scapin, G, Blanchard, J.S. | | Deposit date: | 1996-06-28 | | Release date: | 1997-01-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes.
Biochemistry, 35, 1996
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1DRW
 | | ESCHERICHIA COLI DHPR/NHDH COMPLEX | | Descriptor: | DIHYDRODIPICOLINATE REDUCTASE, NICOTINAMIDE PURIN-6-OL-DINUCLEOTIDE | | Authors: | Reddy, S.G, Scapin, G, Blanchard, J.S. | | Deposit date: | 1996-06-28 | | Release date: | 1997-01-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes.
Biochemistry, 35, 1996
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1DAP
 | | C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+ | | Descriptor: | ACETATE ION, DIAMINOPIMELIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Scapin, G, Reddy, S.G, Blanchard, J.S. | | Deposit date: | 1996-07-08 | | Release date: | 1997-07-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum.
Biochemistry, 35, 1996
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1Q5N
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2CIG
 | | Dihydrofolate reductase from Mycobacterium tuberculosis inhibited by the acyclic 4R isomer of INH-NADP a derivative of the prodrug isoniazid. | | Descriptor: | (4R)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... | | Authors: | Argyrou, A, Vetting, M.W, Aladegbami, B, Blanchard, J.S. | | Deposit date: | 2006-03-20 | | Release date: | 2006-04-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mycobacterium Tuberculosis Dihydrofolate Reductase is a Target for Isoniazid
Nat.Struct.Mol.Biol., 13, 2006
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2C27
 | | The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA. | | Descriptor: | (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside, ACETYL COENZYME *A, COENZYME A, ... | | Authors: | Vetting, M.W, Yu, M, Rendle, P.M, Blanchard, J.S. | | Deposit date: | 2005-09-26 | | Release date: | 2005-12-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Substrate-Induced Conformational Change of Mycobacterium Tuberculosis Mycothiol Synthase.
J.Biol.Chem., 281, 2006
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2BM5
 | | The Structure of MfpA (Rv3361c, P21 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN, SULFATE ION | | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | | Deposit date: | 2005-03-09 | | Release date: | 2005-06-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
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2BUE
 | | Structure of AAC(6')-Ib in complex with Ribostamycin and Coenzyme A. | | Descriptor: | AAC(6')-IB, CALCIUM ION, COENZYME A, ... | | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | | Deposit date: | 2008-03-20 | | Release date: | 2008-09-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Biochemistry, 47, 2008
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2BM4
 | | The Structure of MfpA (Rv3361c, C2 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN | | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | | Deposit date: | 2005-03-09 | | Release date: | 2005-06-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
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2BM6
 | | The Structure of MfpA (Rv3361c, C2221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | | Descriptor: | CESIUM ION, PENTAPEPTIDE REPEAT FAMILY PROTEIN | | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | | Deposit date: | 2005-03-09 | | Release date: | 2005-06-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
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2BM7
 | | The Structure of MfpA (Rv3361c, P3221 Crystal form). The Pentapeptide Repeat Protein from Mycobacterium tuberculosis Folds as A Right- handed Quadrilateral Beta-helix. | | Descriptor: | PENTAPEPTIDE REPEAT FAMILY PROTEIN | | Authors: | Hegde, S.S, Vetting, M.W, Roderick, S.L, Mitchenall, L.A, Maxwell, A, Takiff, H.E, Blanchard, J.S. | | Deposit date: | 2005-03-09 | | Release date: | 2005-06-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
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1OZP
 | | Crystal Structure of Rv0819 from Mycobacterium tuberculosis MshD-Mycothiol Synthase Acetyl-Coenzyme A Complex. | | Descriptor: | ACETYL COENZYME *A, hypothetical protein Rv0819 | | Authors: | Vetting, M.W, Roderick, S.L, Yu, M, Blanchard, J.S. | | Deposit date: | 2003-04-09 | | Release date: | 2003-09-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.
Protein Sci., 12, 2003
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