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3R1K
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BU of 3r1k by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis H37Rv in complex with CoA and an acetamide moiety
Descriptor: ACETAMIDE, COENZYME A, Enhanced intracellular survival protein
Authors:Biswas, T, Chen, W, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2011-03-10
Release date:2011-06-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB.
Proc.Natl.Acad.Sci.USA, 108, 2011
4JD6
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BU of 4jd6 by Molmil
Crystal structure of Mycobacterium tuberculosis Eis in complex with coenzyme A and tobramycin
Descriptor: COENZYME A, Enhanced intracellular survival protein, TOBRAMYCIN
Authors:Biswas, T, Chen, W, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2013-02-23
Release date:2013-10-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase eis.
Chembiochem, 14, 2013
7V0B
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BU of 7v0b by Molmil
Crystal structure of halogenase CtcP from Kitasatospora aureofaciens in complex with FAD
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2022-05-10
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structures and complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway
To Be Published
7V0D
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BU of 7v0d by Molmil
Crystal structure of halogenase CtcP from Kitasatospora aureofaciens
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2022-05-10
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures and complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway
To Be Published
5WMM
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BU of 5wmm by Molmil
Crystal structure of an adenylation domain interrupted by a methylation domain (AMA4) from nonribosomal peptide synthetase TioS
Descriptor: (2S)-2-amino-3-methylbutanoyl (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl hydrogen (S)-phosphate, CALCIUM ION, CHLORIDE ION, ...
Authors:Pang, A.H, Mori, S, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-07-30
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for backbone N-methylation by an interrupted adenylation domain.
Nat. Chem. Biol., 14, 2018
6B0U
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BU of 6b0u by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a Lys-containing peptide
Descriptor: COENZYME A, N-acetyltransferase Eis, Synthetic peptide ATKAPAKKA
Authors:Biswas, T, Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-09-15
Release date:2018-01-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
Biochemistry, 57, 2018
6BZQ
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BU of 6bzq by Molmil
Crystal structure of halogenase PltM in complex with FAD
Descriptor: BROMIDE ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-12-25
Release date:2019-03-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
6BZZ
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BU of 6bzz by Molmil
Crystal structure of halogenase PltM in complex with partially bound FAD
Descriptor: CALCIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, Halogenase PltM
Authors:Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-12-26
Release date:2019-03-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
6B3T
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BU of 6b3t by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b
Descriptor: 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5H-[1,2,4]triazino[5,6-b]indole, COENZYME A, N-acetyltransferase Eis, ...
Authors:Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Ngo, H.X, Tsodikov, O.V.
Deposit date:2017-09-24
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
ACS Infect Dis, 4, 2018
6BZA
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BU of 6bza by Molmil
Crystal structure of halogenase PltM in complex with phloroglucinol and FAD
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Halogenase PltM, ...
Authors:Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-12-22
Release date:2019-03-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
6BZT
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BU of 6bzt by Molmil
Crystal structure of halogenase PltM L111Y mutant in complex with FAD
Descriptor: BROMIDE ION, CALCIUM ION, CHLORIDE ION, ...
Authors:Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2017-12-26
Release date:2019-03-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10, 2019
7JSL
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BU of 7jsl by Molmil
Crystal structure of the DNA binding domain of human transcription factor ERF in the oxidized form, in complex with double-stranded DNA ACCGGAAGTG
Descriptor: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2020-08-14
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.51 Å)
Cite:Structural Insight into the DNA Binding Function of Transcription Factor ERF.
Biochemistry, 2020
7JSA
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BU of 7jsa by Molmil
Crystal structure of the DNA binding domain of human transcription factor ERF in the reduced form, in complex with double-stranded DNA ACCGGAAGTG
Descriptor: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF
Authors:Hou, C, Tsodikov, O.V.
Deposit date:2020-08-14
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Insight into the DNA Binding Function of Transcription Factor ERF.
Biochemistry, 2020
8G7F
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BU of 8g7f by Molmil
Crystal Structure of FosB from Bacillus cereus with Zinc and 1-hydroxypropylphosphonic acid
Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K.
Deposit date:2023-02-16
Release date:2023-06-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus.
Rsc Med Chem, 14, 2023
8G7G
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BU of 8g7g by Molmil
Crystal Structure of FosB from Bacillus cereus with Zinc and (1-hydroxy-2-methylpropyl)phosphonic acid
Descriptor: FORMIC ACID, MAGNESIUM ION, Metallothiol transferase FosB, ...
Authors:Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K.
Deposit date:2023-02-16
Release date:2023-06-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus.
Rsc Med Chem, 14, 2023
8G7H
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BU of 8g7h by Molmil
Crystal Structure of FosB from Bacillus cereus with Zinc and (1-hydroxypropan-2-yl)phosphonic acid
Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K.
Deposit date:2023-02-16
Release date:2023-06-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus.
Rsc Med Chem, 14, 2023
8G7I
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BU of 8g7i by Molmil
Crystal Structure of FosB from Bacillus cereus with Zinc and Sulfate
Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K.
Deposit date:2023-02-16
Release date:2023-06-14
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus.
Rsc Med Chem, 14, 2023
5EBV
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BU of 5ebv by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 11c and CoA
Descriptor: 5-(4-chlorophenyl)-~{N}-[3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)propyl]-4-methyl-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, CHLORIDE ION, COENZYME A, ...
Authors:Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2015-10-19
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
Acs Chem.Biol., 11, 2016
5EC4
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BU of 5ec4 by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 13g and CoA
Descriptor: 5-(3-chlorophenyl)-4-methyl-~{N}-(3-morpholin-4-ylpropyl)-1,1-bis(oxidanylidene)-1,2-thiazol-3-amine, COENZYME A, Enhanced intracellular survival protein
Authors:Gajadeera, C.S, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2015-10-20
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
Acs Chem.Biol., 11, 2016
3LT3
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BU of 3lt3 by Molmil
Crystal structure of Rv3671c from M. tuberculosis H37Rv, Ser343Ala mutant, inactive form
Descriptor: POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE
Authors:Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V.
Deposit date:2010-02-14
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
3K6Y
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BU of 3k6y by Molmil
Crystal structure of Rv3671c protease from M. tuberculosis, active form
Descriptor: POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE
Authors:Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V.
Deposit date:2009-10-10
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
6X10
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BU of 6x10 by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with haloperidol
Descriptor: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, CHLORIDE ION, GLYCEROL, ...
Authors:Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2020-05-17
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance
Rsc Med Chem, 12, 2021
6X6G
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BU of 6x6g by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with droperidol
Descriptor: 3-[1-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-2,3,4,5-tetrahydropyridin-4-yl]-1~{H}-benzimidazol-2-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2020-05-28
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance
Rsc Med Chem, 12, 2021
6X6I
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BU of 6x6i by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT543
Descriptor: 4-(4-benzyl-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2020-05-28
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance
Rsc Med Chem, 12, 2021
6X6Y
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BU of 6x6y by Molmil
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V.
Deposit date:2020-05-29
Release date:2021-06-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance
Rsc Med Chem, 12, 2021

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數據於2024-06-26公開中

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