4CGV
| First TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD | Descriptor: | GLYCEROL, HEAT SHOCK PROTEIN HSP 90-ALPHA, RNA POLYMERASE II-ASSOCIATED PROTEIN 3 | Authors: | Roe, S.M, Pal, M. | Deposit date: | 2013-11-26 | Release date: | 2014-05-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, 22, 2014
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4CGW
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4CGU
| Full length Tah1 bound to yeast PIH1 and HSP90 peptide SRMEEVD | Descriptor: | GLYCEROL, HEAT SHOCK PROTEIN HSP 90-ALPHA, PROTEIN INTERACTING WITH HSP90 1, ... | Authors: | Roe, S.M, Pal, M. | Deposit date: | 2013-11-26 | Release date: | 2014-05-14 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, 22, 2014
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4CE1
| Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. | Descriptor: | 15-Chloro-16,18-dihydroxy-2-methyl-3,4,7,8,9,10,11,12-octahydrobenz[c][1]azacyclohexadecine-1,13(2H,14H)-dione, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | Authors: | Roe, S.M, Parry-Morris, S, Prodromou, C. | Deposit date: | 2013-11-08 | Release date: | 2014-01-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Synthesis of Macrolactam Analogues of Radicicol and Their Binding to Heat Shock Protein Hsp90. Org.Biomol.Chem., 12, 2014
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4CE2
| Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. | Descriptor: | (9E)-19-CHLORANYL-13-METHYL-16,18-BIS(OXIDANYL)-13-AZABICYCLO[13.4.0]NONADECA-1(15),9,16,18-TETRAENE-3,14-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | Authors: | Roe, S.M, Parry-Morris, S, Prodromou, C. | Deposit date: | 2013-11-08 | Release date: | 2014-01-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org. Biomol. Chem., 12, 2014
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4CHH
| N-terminal domain of yeast PIH1p | Descriptor: | 1,2-ETHANEDIOL, PROTEIN INTERACTING WITH HSP90 1 | Authors: | Roe, S.M, Pal, M. | Deposit date: | 2013-12-02 | Release date: | 2014-05-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1. Structure, 22, 2014
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2WEQ
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2WEP
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2WER
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2XD6
| Hsp90 complexed with a resorcylic acid macrolactone. | Descriptor: | (5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H, Moody, C.J. | Deposit date: | 2010-04-29 | Release date: | 2010-08-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies. Chemistry, 16, 2010
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2V0P
| The Structure of Tap42 Alpha4 Subunit | Descriptor: | TYPE 2A PHOSPHATASE-ASSOCIATED PROTEIN 42, ZINC ION | Authors: | Roe, S.M, Yang, J, Barford, D. | Deposit date: | 2007-05-15 | Release date: | 2007-07-17 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of Tap42/Alpha4 Reveals a Tetratricopeptide Repeat-Like Fold and Provides Insights Into Pp2A Regulation. Biochemistry, 46, 2007
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2YI5
| Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. | Descriptor: | 4-CHLORO-6-[5-(3,4-DIMETHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL]BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H. | Deposit date: | 2011-05-10 | Release date: | 2012-05-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors. Plos One, 7, 2012
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2YGA
| E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin | Descriptor: | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H. | Deposit date: | 2011-04-12 | Release date: | 2011-11-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise with Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90. Faseb J., 25, 2011
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2YI0
| Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. | Descriptor: | 4-CHLORO-6-[5-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-4-YL]BENZENE-1,3-DIOL, HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION | Authors: | Roe, S.M, Prodromou, C, Pearl, L.H. | Deposit date: | 2011-05-10 | Release date: | 2012-05-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Co-Crystalization and in Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors. Plos One, 7, 2012
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4V81
| The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, SULFATE ION, ... | Authors: | Dekker, C, Roe, S.M, McCormack, E.A, Beuron, F, Pearl, L.H, Willison, K.R. | Deposit date: | 2010-10-17 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. Embo J., 30, 2011
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4BA9
| The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1 | Descriptor: | DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ... | Authors: | Grummitt, C.G, Kilkenny, M.L, Frey, A, Roe, S.M, Oliver, A.W, Sale, J.E, Pearl, L.H. | Deposit date: | 2012-09-12 | Release date: | 2013-09-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1 To be Published
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2BYE
| NMR solution structure of phospholipase c epsilon RA 1 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2BYF
| NMR solution structure of phospholipase c epsilon RA 2 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2C2V
| Crystal structure of the CHIP-UBC13-UEV1a complex | Descriptor: | STIP1 homology and U box-containing protein 1, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1 | Authors: | Zhang, M, Roe, S.M, Pearl, L.H. | Deposit date: | 2005-09-30 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol. Cell, 20, 2005
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2C2L
| Crystal structure of the CHIP U-box E3 ubiquitin ligase | Descriptor: | CARBOXY TERMINUS OF HSP70-INTERACTING PROTEIN, HSP90, NICKEL (II) ION, ... | Authors: | Zhang, M, Roe, S.M, Pearl, L.H. | Deposit date: | 2005-09-29 | Release date: | 2005-11-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex Mol.Cell, 20, 2005
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1CBN
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6ZUJ
| Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen). | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Koulouris, C.R, Bax, B.D, Roe, S.M, Atack, J.R. | Deposit date: | 2020-07-23 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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6ZSP
| Human serine racemase bound to ATP and malonate. | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Koulouris, C.R, Bax, B.D, Roe, S.M, Atack, J.R. | Deposit date: | 2020-07-16 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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1W9H
| The Structure of a Piwi protein from Archaeoglobus fulgidus. | Descriptor: | CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ... | Authors: | Parker, J.S, Roe, S.M, Barford, D. | Deposit date: | 2004-10-13 | Release date: | 2005-01-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity Embo J., 23, 2004
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1W4S
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